{
  "abstract": "The selective cleavage of the C–O bond of unactivated alkyl esters remains a major challenge to use them as C(sp³)‐electrophiles in cross‐coupling chemistry. Here, we report a systematic study on the dealkylation of alkyl formates using iodide salts, revealing the pivotal role of the Lewis acidic countercation (K⁺, Na⁺, Li⁺, Ca²⁺, Mg²⁺, and Al³⁺) in accelerating C–O bond cleavage. Kinetic analyses demonstrate a seven‐order‐of‐magnitude rate enhancement when replacing LiI with AlI₃. To highlight the synthetic potential of this finding, we further integrate this reactivity into a tandem catalytic system combining AlI₃ and a ruthenium catalyst, achieving efficient protodecarboxylation of alkyl formates to alkanes with up to 82 % yield.",
  "abstract_shown": true,
  "affiliations": [],
  "article_type": null,
  "arxiv": null,
  "author_total": 3,
  "authors": [
    {
      "name": "Félix Mandelaire"
    },
    {
      "name": "Thibault Cantat"
    },
    {
      "name": "Lucile Anthore-Dalion"
    }
  ],
  "bibtex": "https://research.draconitic.com/paper/71r69ppp76s6f.bib",
  "cited_by": 0,
  "doi": "10.1002/cctc.70690",
  "fulltext_url": null,
  "id": "71r69ppp76s6f",
  "issns": [
    "1867-3880",
    "1867-3899"
  ],
  "landing_url": "https://hal.science/hal-05788196v1",
  "language": "en",
  "licence": "CC-BY-NC-ND-4.0",
  "licence_label": "CC BY-NC-ND 4.0",
  "licence_source": "article",
  "licence_url": "https://creativecommons.org/licenses/by-nc-nd/4.0/",
  "metadata_licence": null,
  "native_subjects": [
    [
      "hal",
      "0.chim"
    ],
    [
      "hal",
      "1.chim.cata"
    ],
    [
      "hal",
      "1.chim.orga"
    ],
    [
      "openalex",
      "1605|Catalytic Cross-Coupling Reactions"
    ]
  ],
  "openalex": "W7141589239",
  "pdf_url": "https://hal.science/hal-05788196/document",
  "pmcid": null,
  "pmid": null,
  "published": "2026-10-09",
  "publisher": "Wiley",
  "ris": "https://research.draconitic.com/paper/71r69ppp76s6f.ris",
  "sources": [
    {
      "first_seen": "2026-10-30T12:17:52Z",
      "native_id": "hal-05788196",
      "source": "hal",
      "url": "https://hal.science/hal-05788196v1"
    }
  ],
  "subjects": [
    {
      "field": "chemistry",
      "origin": "hal:1.chim.cata",
      "subfield": "catalysis"
    },
    {
      "field": "chemistry",
      "origin": "hal:1.chim.orga",
      "subfield": "organic"
    }
  ],
  "title": "Controlled Dealkylation of Alkyl Esters With Halide Salts and Application in Tandem‐Catalyzed Protodecarboxylation of Organic Formates",
  "title_text": "Controlled Dealkylation of Alkyl Esters With Halide Salts and Application in Tandem‐Catalyzed Protodecarboxylation of Organic Formates",
  "type": "peer-reviewed",
  "updated_at": "2026-10-30T12:17:52Z",
  "url": "https://research.draconitic.com/paper/71r69ppp76s6f",
  "venue": "ChemCatChem",
  "versions": []
}