{
  "abstract": "Objective\n\nMinor strokes may be associated with early neurological deterioration (END) and disabilities. The objective was to investigate the role of serum glial fibrillary acidic protein (GFAP) levels in predicting END.Methods\n\nData originated from a multicenter cohort study conducted prospectively. ΔGFAP was calculated as the ratio of post-thrombolysis GFAP at 24 h to baseline GFAP. Univariable and multivariable binary logistic regression analyses were performed to assess the association between ∆GFAP and END, and a nomogram was established to illustrate its predictive value.Results\n\nEND occurred in 20 (7.35%) of the 272 patients with minor stroke who underwent intravenous thrombolysis (IVT). Elevated ∆GFAP was independently associated with END (OR, 3.50; 95% CI, 1.67 to 7.31; p < 0.001), even after adjusting for confounders (adjusted OR, 4.64; 95% CI, 1.86 to 11.54; p < 0.001). Furthermore, a model combining ∆GFAP, age, and National Institutes of Health Stroke Scale (NIHSS) score at admission demonstrated a good predictive value for END (AUC = 0.77; 95% CI, 0.67 to 0.89).Interpretation\n\n∆GFAP is a strong, independent predictor of END in patients with minor strokes. Integrating ∆GFAP, age, and NIHSS score into a prognostic model results in a good discriminative ability for predicting END.",
  "abstract_shown": true,
  "affiliations": [
    "Stroke Center, Department of Neurology, The First Hospital of Jilin University, Changchun, China.",
    "Department of Neurology, Songyuan Central Hospital, Songyuan, China.",
    "Department of Neurology, Jilin Neuropsychiatric Hospital, Siping, China.",
    "Stroke Center, Department of Neurology, Siping Central People's Hospital, Siping, China.",
    "Department of Neurology, Tonghua City Vascular Disease Hospital and Dongchang District People's Hospital, Tonghua, China.",
    "Department of Neurology, Songyuan Jilin Oilfield Hospital, Songyuan, China.",
    "Stroke Center, Department of Neurology, Dehuishi People's Hospital, Changchun, China.",
    "Department of Neurology, Affiliated Hospital of Jilin Medical College, Jilin, China.",
    "Department of Neurology, Songyuan Hospital of Integrated Traditional Chinese and Western Medicine, Songyuan, China.",
    "Stroke Center, Department of Neurology, Qianguoerros Mongolian Autonomous County Hospital, Songyuan, China.",
    "Department of Neurology, Jilin City Hospital of Chemical Industry, Jilin, China.",
    "Department of Neurology, Changchun People's Hospital, Changchun, China.",
    "Department of Neurology, Changchun Second Hospital, Changchun, China.",
    "Department of Neurology, Dongliao First People's Hospital, Liaoyuan, China.",
    "Department of Neurology, Jilin People's Hospital, Jilin, China.",
    "Department of Neurology, Jilin Province People's Hospital, Changchun, China.",
    "Stroke Center, Department of Neurology, Jilin Central General Hospital, Jilin, China.",
    "Neuroscience Research Center, Department of Neurology, The First Hospital of Jilin University, Changchun, China."
  ],
  "article_type": "research article",
  "arxiv": null,
  "author_total": 27,
  "authors": [
    {
      "affs": [
        0
      ],
      "name": "Jie Zhou"
    },
    {
      "affs": [
        0
      ],
      "name": "Yang Qu"
    },
    {
      "affs": [
        0
      ],
      "name": "Reziya Abuduxukuer"
    },
    {
      "affs": [
        0
      ],
      "name": "Peng Zhang",
      "orcid": "0000-0001-5536-0255"
    },
    {
      "affs": [
        1
      ],
      "name": "Ting Wang"
    },
    {
      "affs": [
        2
      ],
      "name": "Jian-Hua Gao"
    },
    {
      "affs": [
        3
      ],
      "name": "De-Wang Pan"
    },
    {
      "affs": [
        4
      ],
      "name": "Zhi-Mei Yuan"
    },
    {
      "affs": [
        5
      ],
      "name": "Chun-Ying Li"
    },
    {
      "affs": [
        6
      ],
      "name": "Li-Ping Chen"
    },
    {
      "affs": [
        7
      ],
      "name": "Jin-Hua Chen"
    },
    {
      "affs": [
        8
      ],
      "name": "Ji-Liang Gu"
    },
    {
      "affs": [
        9
      ],
      "name": "An-Ying Wang"
    },
    {
      "affs": [
        7
      ],
      "name": "Li-Gang Jiang"
    },
    {
      "affs": [
        10
      ],
      "name": "Liang Liu"
    },
    {
      "affs": [
        11,
        12
      ],
      "name": "Yong-Fei Jiang"
    },
    {
      "affs": [
        13
      ],
      "name": "Chun-Fei Wang"
    },
    {
      "affs": [
        14
      ],
      "name": "Yan Jia"
    },
    {
      "affs": [
        10
      ],
      "name": "Hong Xin"
    },
    {
      "affs": [
        10
      ],
      "name": "Chun-Li Jiang"
    },
    {
      "affs": [
        15
      ],
      "name": "Ying-Bin Qi"
    },
    {
      "affs": [
        16
      ],
      "name": "Xue-Feng Hu"
    },
    {
      "affs": [
        15
      ],
      "name": "Song Li"
    },
    {
      "affs": [
        0
      ],
      "name": "Hang Jin",
      "orcid": "0000-0003-0300-5918"
    },
    {
      "affs": [
        0,
        17
      ],
      "name": "Zhen-Ni Guo"
    },
    {
      "affs": [
        0
      ],
      "name": "Yi Yang",
      "orcid": "0000-0002-9729-8522"
    },
    {
      "name": "Biomarkers of Brain Injury Investigator Study Group"
    }
  ],
  "bibtex": "https://research.draconitic.com/paper/71wgf0xjffxzr.bib",
  "cited_by": 0,
  "doi": "10.1002/acn3.70552",
  "fulltext_url": "https://europepmc.org/articles/PMC13682409",
  "id": "71wgf0xjffxzr",
  "issns": [
    "2328-9503"
  ],
  "landing_url": "https://europepmc.org/article/MED/42899785",
  "language": "eng",
  "licence": "CC-BY",
  "licence_label": "CC BY",
  "licence_source": "article",
  "licence_url": "https://creativecommons.org/licenses/by/4.0/",
  "metadata_licence": null,
  "native_subjects": [
    [
      "openalex",
      "2713|Acute Ischemic Stroke Management"
    ]
  ],
  "openalex": "W7222992912",
  "pdf_url": "https://europepmc.org/articles/PMC13682409?pdf=render",
  "pmcid": "PMC13682409",
  "pmid": "42899785",
  "published": "2026-10-20",
  "publisher": null,
  "ris": "https://research.draconitic.com/paper/71wgf0xjffxzr.ris",
  "sources": [
    {
      "first_seen": "2026-10-30T12:19:32Z",
      "native_id": "MED:42899785",
      "source": "europepmc",
      "url": "https://europepmc.org/article/MED/42899785"
    }
  ],
  "subjects": [
    {
      "field": "medicine",
      "origin": "openalex:2713|Acute Ischemic Stroke Management",
      "subfield": "epidemiology-public-health"
    }
  ],
  "title": "Dynamic Changes in Serum Glial Fibrillary Acidic Protein Levels Predicts Early Neurological Deterioration After Intravenous Thrombolysis in Minor Stroke.",
  "title_text": "Dynamic Changes in Serum Glial Fibrillary Acidic Protein Levels Predicts Early Neurological Deterioration After Intravenous Thrombolysis in Minor Stroke.",
  "type": "peer-reviewed",
  "updated_at": "2026-10-30T12:19:32Z",
  "url": "https://research.draconitic.com/paper/71wgf0xjffxzr",
  "venue": "Annals of clinical and translational neurology",
  "versions": []
}