{
  "abstract": "Histone deacetylases (HDACs) are crucial epigenetic regulators that modulate chromatin structure and gene expression through histone deacetylation. Stevia rebaudiana, a natural source of high-intensity sweeteners, faces significant cultivation challenges due to environmental stresses such as osmotic stress and salinity. However, the HDAC gene family in S. rebaudiana remains largely uncharacterized. Here, we present the first genome-wide analysis of the HDAC family in S. rebaudiana, identifying 22 SrHDAC transcripts derived from 18 gene loci, which were classified into three subfamilies (RPD3/HDA1, SIR2, and HD2). Systematic characterization of gene structure, conserved domains, and promoter cis elements indicated their potential involvement in hormone signaling and abiotic stress regulation. Expression profiling revealed tissue-specific expression patterns and differential responses to methyl jasmonate (MeJA) treatment and PEG-induced osmotic stress. Subcellular localization of representative proteins in Nicotiana benthamiana leaf cells supported nucleolar-associated functions. These findings provide a foundation for understanding HDAC-mediated epigenetic regulation in S. rebaudiana growth, development, and stress adaptation, and identify candidate genes for future functional studies toward stress-tolerant cultivar improvement.",
  "abstract_shown": true,
  "affiliations": [
    "Beijing Life Science Academy, Beijing 102206, China",
    "Hubei Shizhen Laboratory, School of Basic Medical Sciences, Hubei University of Chinese Medicine, Wuhan 430065, China",
    "College of Agriculture, South China Agricultural University, Guangzhou 510642, China",
    "South China Botanical Garden, Chinese Academy of Sciences, Guangzhou 510650, China"
  ],
  "article_type": "research article",
  "arxiv": null,
  "author_total": 7,
  "authors": [
    {
      "affs": [
        0,
        1,
        2
      ],
      "name": "Chaoyong Zhao"
    },
    {
      "affs": [
        0
      ],
      "name": "Yaning Fu"
    },
    {
      "affs": [
        3
      ],
      "name": "Daiqi Wang"
    },
    {
      "affs": [
        3
      ],
      "name": "Kai Lin"
    },
    {
      "affs": [
        0
      ],
      "name": "Lingling Yun"
    },
    {
      "affs": [
        0
      ],
      "name": "Fen Xie"
    },
    {
      "affs": [
        1,
        3
      ],
      "name": "Genxiang Bai"
    }
  ],
  "bibtex": "https://research.draconitic.com/paper/72b8xwt9tevn6.bib",
  "cited_by": 0,
  "doi": "10.3390/ijms27209177",
  "fulltext_url": "https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13705409/?tool=EBI",
  "id": "72b8xwt9tevn6",
  "issns": [
    "1422-0067"
  ],
  "landing_url": "https://www.mdpi.com/1422-0067/27/20/9177",
  "language": "eng",
  "licence": "CC-BY-4.0",
  "licence_label": "CC BY 4.0",
  "licence_source": "article",
  "licence_url": "https://creativecommons.org/licenses/by/4.0/",
  "metadata_licence": null,
  "native_subjects": [
    [
      "openalex",
      "1110|Plant Molecular Biology Research"
    ]
  ],
  "openalex": "W7222682689",
  "pdf_url": "https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13705409/pdf/?tool=EBI",
  "pmcid": "PMC13705409",
  "pmid": null,
  "published": "2026-10-01",
  "publisher": "MDPI AG",
  "ris": "https://research.draconitic.com/paper/72b8xwt9tevn6.ris",
  "sources": [
    {
      "first_seen": "2026-10-30T12:18:57Z",
      "native_id": "10.3390/ijms27209177",
      "source": "crossref",
      "url": "https://www.mdpi.com/1422-0067/27/20/9177"
    },
    {
      "first_seen": "2026-10-30T12:21:49Z",
      "native_id": "PMC:PMC13705409",
      "source": "europepmc",
      "url": "https://europepmc.org/article/PMC/PMC13705409"
    }
  ],
  "subjects": [
    {
      "field": "biology",
      "origin": "openalex:1110|Plant Molecular Biology Research",
      "subfield": "plant-biology"
    }
  ],
  "title": "Genome-Wide Identification and Expression Analysis of the HDAC Gene Family in Stevia rebaudiana",
  "title_text": "Genome-Wide Identification and Expression Analysis of the HDAC Gene Family in Stevia rebaudiana",
  "type": "peer-reviewed",
  "updated_at": "2026-10-30T12:21:49Z",
  "url": "https://research.draconitic.com/paper/72b8xwt9tevn6",
  "venue": "International Journal of Molecular Sciences",
  "versions": []
}