{
  "abstract": "A Sister Mary Joseph nodule is a cutaneous umbilical metastasis indicating advanced intra-abdominal malignancy with a poor prognosis. An 84-year-old man presented with an umbilical nodule that was completely excised and diagnosed to be metastatic adenocarcinoma from advanced gastric cancer. After FOLFOX-nivolumab, the primary lesion and lymphadenopathy showed near-complete radiographic regression, and conversion total gastrectomy achieved a pathological complete response. The indications for surgery were insufficient, and therefore systemic therapy or surveillance was continued. This case highlights the uncertainty surrounding conversion surgery after an immune checkpoint inhibitor-induced near-complete response and suggests that neither umbilical metastasis nor advanced age alone should preclude the consideration of curative-intent multimodal treatment in fit patients.",
  "abstract_shown": true,
  "affiliations": [],
  "article_type": null,
  "arxiv": null,
  "author_total": 5,
  "authors": [
    {
      "name": "Shuhei Suzuki"
    },
    {
      "name": "Yuka Kobayashi"
    },
    {
      "name": "Takashi Oizumi"
    },
    {
      "name": "Erina Yakuwa"
    },
    {
      "name": "Rintaro Ohe"
    }
  ],
  "bibtex": "https://research.draconitic.com/paper/72nd5mhgt6nrx.bib",
  "cited_by": 0,
  "doi": "10.2169/internalmedicine.7883-26",
  "fulltext_url": "https://www.jstage.jst.go.jp/article/internalmedicine/advpub/0/advpub_7883-26/_article",
  "id": "72nd5mhgt6nrx",
  "issns": [
    "1349-7235",
    "0918-2918"
  ],
  "landing_url": "https://www.jstage.jst.go.jp/article/internalmedicine/advpub/0/advpub_7883-26/_article",
  "language": null,
  "licence": "CC-BY-NC-ND",
  "licence_label": "CC BY-NC-ND",
  "licence_source": "journal",
  "licence_url": "https://creativecommons.org/licenses/by-nc-nd/4.0/",
  "metadata_licence": null,
  "native_subjects": [
    [
      "jstage-journal",
      "medicine/general"
    ],
    [
      "openalex",
      "2740|Gastric Cancer Management and Outcomes"
    ]
  ],
  "openalex": "W7204771915",
  "pdf_url": "https://www.jstage.jst.go.jp/article/internalmedicine/advpub/0/advpub_7883-26/_pdf",
  "pmcid": null,
  "pmid": null,
  "published": "2026-09-01",
  "publisher": null,
  "ris": "https://research.draconitic.com/paper/72nd5mhgt6nrx.ris",
  "sources": [
    {
      "first_seen": "2026-10-30T12:17:31Z",
      "native_id": "10.2169/internalmedicine.7883-26",
      "source": "jstage",
      "url": "https://www.jstage.jst.go.jp/article/internalmedicine/advpub/0/advpub_7883-26/_article"
    }
  ],
  "subjects": [
    {
      "field": "medicine",
      "origin": "openalex:2740|Gastric Cancer Management and Outcomes",
      "subfield": "general"
    }
  ],
  "title": "Pathological Complete Response and Conversion Gastrectomy after Nivolumab Plus FOLFOX in an 84-Year-Old Man with MSI-High Gastric Cancer Presenting as a Sister Mary Joseph Nodule: A Case Report",
  "title_text": "Pathological Complete Response and Conversion Gastrectomy after Nivolumab Plus FOLFOX in an 84-Year-Old Man with MSI-High Gastric Cancer Presenting as a Sister Mary Joseph Nodule: A Case Report",
  "type": "peer-reviewed",
  "updated_at": "2026-10-30T12:17:31Z",
  "url": "https://research.draconitic.com/paper/72nd5mhgt6nrx",
  "venue": "Internal Medicine",
  "versions": []
}