{
  "abstract": "Analysis of prevalent orthogroups (OGs) in a collection of F plasmids from extraintestinal Escherichia coli ST131 isolates has led to the identification of two groups of previously uncharacterized cargo genes that may be widely distributed among F plasmids of pathogenic E. coli. Group 1 comprises four OGs whose encoded proteins are predicted to be involved in transport-related functions. The corresponding genes cluster with other genes associated with metabolism and are highly prevalent in extraintestinal ST131 isolates. Group 2 comprises several OGs whose encoded proteins currently have unknown functions. These OGs are present in a large proportion of F plasmids from both intestinal and extraintestinal E. coli isolates. The corresponding genes cluster within an F-plasmid region that also contains genes involved in DNA metabolism, suggesting that the proteins encoded by these newly identified OGs may likewise contribute to F-plasmid DNA biology. Characterizing the functions of these newly identified proteins may improve our understanding of the contribution of F plasmid to E. coli virulence and reveal novel targets for antimicrobial intervention, either by limiting F-plasmid dissemination among multidrug-resistant (MDR) E. coli strains or by directly targeting plasmid-carrying bacteria.",
  "abstract_shown": true,
  "affiliations": [
    "Universitat de Barcelona"
  ],
  "article_type": "New results",
  "arxiv": null,
  "author_total": 9,
  "authors": [
    {
      "name": "S. Guirao-Rico"
    },
    {
      "name": "S. C. Flament-Simon"
    },
    {
      "name": "C. Madrid"
    },
    {
      "name": "C. Balsalobre"
    },
    {
      "name": "M. Huttener"
    },
    {
      "name": "J. E. Blanco"
    },
    {
      "name": "J. Blanco"
    },
    {
      "name": "J. Rozas"
    },
    {
      "affs": [
        0
      ],
      "name": "A. Juarez"
    }
  ],
  "bibtex": "https://research.draconitic.com/paper/72vt44hthg0p1.bib",
  "cited_by": 0,
  "doi": "10.64898/2026.11.04.764203",
  "fulltext_url": "https://www.biorxiv.org/content/10.64898/2026.11.04.764203v1.full",
  "id": "72vt44hthg0p1",
  "issns": [],
  "landing_url": "https://www.biorxiv.org/content/10.64898/2026.11.04.764203v1",
  "language": null,
  "licence": "CC-BY",
  "licence_label": "CC BY",
  "licence_source": "article",
  "licence_url": "https://creativecommons.org/licenses/by/4.0/",
  "metadata_licence": null,
  "native_subjects": [
    [
      "biorxiv",
      "genomics"
    ]
  ],
  "openalex": null,
  "pdf_url": "https://www.biorxiv.org/content/10.64898/2026.11.04.764203v1.full.pdf",
  "pmcid": null,
  "pmid": null,
  "published": "2026-11-04",
  "publisher": null,
  "ris": "https://research.draconitic.com/paper/72vt44hthg0p1.ris",
  "sources": [
    {
      "first_seen": "2026-11-05T12:20:42Z",
      "native_id": "10.64898/2026.11.04.764203",
      "source": "biorxiv",
      "url": "https://www.biorxiv.org/content/10.64898/2026.11.04.764203v1"
    }
  ],
  "subjects": [
    {
      "field": "biology",
      "origin": "biorxiv:genomics",
      "subfield": "genetics-genomics"
    }
  ],
  "title": "Highly prevalent cargo genes of F plasmids harbored in pathogenic Escherichia coli",
  "title_text": "Highly prevalent cargo genes of F plasmids harbored in pathogenic Escherichia coli",
  "type": "preprint",
  "updated_at": "2026-11-07T00:20:54Z",
  "url": "https://research.draconitic.com/paper/72vt44hthg0p1",
  "venue": "bioRxiv",
  "versions": []
}