{
  "abstract": "An oxalyl halide-mediated conversion of amino acid derivatives to halogenated α,β-unsaturated γ-lactams is reported. The metal-free transformation provides functionalized γ-lactams from readily available amino acid derivatives. Variation of the amine substituent, oxalyl halide, amino acid side chain, and external nucleophile enables independent diversification at N1, C3, C4, and C5, respectively. Mechanistic studies support an activation-cyclization-halogenation sequence involving multiple modes of oxalyl halide reactivity.",
  "abstract_shown": true,
  "affiliations": [
    "Department of Chemistry",
    "Bar-Ilan University",
    "Schulich Faculty of Chemistry",
    "Technion-Israel Institute of Technology"
  ],
  "article_type": null,
  "arxiv": null,
  "author_total": 4,
  "authors": [
    {
      "affs": [
        0,
        1
      ],
      "name": "Hajar Aledwan"
    },
    {
      "affs": [
        0,
        1
      ],
      "name": "Abhijit Kashid"
    },
    {
      "affs": [
        2,
        3
      ],
      "name": "Natalia Fridman"
    },
    {
      "affs": [
        0,
        1
      ],
      "name": "Abed Saady"
    }
  ],
  "bibtex": "https://research.draconitic.com/paper/72w18whdtqxek.bib",
  "cited_by": 0,
  "doi": "10.26434/chemrxiv.15011055/v1",
  "fulltext_url": null,
  "id": "72w18whdtqxek",
  "issns": [],
  "landing_url": "https://chemrxiv.org/doi/full/10.26434/chemrxiv.15011055/v1",
  "language": null,
  "licence": "CC-BY",
  "licence_label": "CC BY",
  "licence_source": "journal",
  "licence_url": "https://creativecommons.org/licenses/by/4.0/",
  "metadata_licence": null,
  "native_subjects": [
    [
      "openalex",
      "1605|Organic Chemistry Synthesis Methods"
    ]
  ],
  "openalex": "W7223691601",
  "pdf_url": "https://chemrxiv.org/doi/pdf/10.26434/chemrxiv.15011055/v1",
  "pmcid": null,
  "pmid": null,
  "published": "2026-10-26",
  "publisher": "American Chemical Society (ACS)",
  "ris": "https://research.draconitic.com/paper/72w18whdtqxek.ris",
  "sources": [
    {
      "first_seen": "2026-10-30T12:17:26Z",
      "native_id": "10.26434/chemrxiv.15011055",
      "source": "chemrxiv",
      "url": "https://chemrxiv.org/doi/full/10.26434/chemrxiv.15011055/v1"
    }
  ],
  "subjects": [
    {
      "field": "chemistry",
      "origin": "openalex:1605|Organic Chemistry Synthesis Methods",
      "subfield": "organic"
    }
  ],
  "title": "Oxalyl Halide-Mediated Synthesis of Halogenated α,β-Unsaturated γ-Lactams from Amino Acid Derivatives",
  "title_text": "Oxalyl Halide-Mediated Synthesis of Halogenated α,β-Unsaturated γ-Lactams from Amino Acid Derivatives",
  "type": "preprint",
  "updated_at": "2026-10-30T12:17:26Z",
  "url": "https://research.draconitic.com/paper/72w18whdtqxek",
  "venue": "ChemRxiv",
  "versions": []
}