{
  "abstract": "Set1 is the catalytic subunit of SET1C or COMPASS, which methylates histone H3K4 and serves as a scaffold for the association of seven tightly bound polypeptides. We have employed yeast two-hybrid screenings to determine the interactome of Set1 and each subunit, providing a unique resource for exploring known and novel roles of the complex. Our screenings identified a multitude of potential interactors involved in chromatin regulation, DNA replication, meiotic breaks, and Ty transposition, processes previously associated with SET1C. Consistent with Set1 being an RNA-binding protein, the screens link SET1C to multiple aspects of RNA biogenesis, including pre-mRNA splicing and polyadenylation. The results reveal that several importins are candidate interactors of Set1, along with RGG motif-containing proteins, providing insights into the mechanisms by which Set1 moves between cytoplasmic and nuclear compartments. We further reveal that reconstituted SET1C interacts with the AT-hook domain of the chromatin remodeler Snf2 and methylates multiple arginines within this domain. In vivo, we report that the ARTSTRGR AT-hook motif is methylated in a Set1-dependent manner, revealing new interplay between lysine and arginine methylation.",
  "abstract_shown": true,
  "affiliations": [],
  "article_type": null,
  "arxiv": null,
  "author_total": 15,
  "authors": [
    {
      "name": "Pierre Luciano"
    },
    {
      "name": "Kihyun Park"
    },
    {
      "name": "Stephane Audebert"
    },
    {
      "name": "Luc Camoin"
    },
    {
      "name": "Carlos A Niño"
    },
    {
      "name": "Da Kyeong Park"
    },
    {
      "name": "Isabella E Maudlin"
    },
    {
      "name": "Marion Dubarry"
    },
    {
      "name": "Lara Lee"
    },
    {
      "name": "Marlene Oeffinger"
    },
    {
      "name": "Jean D Beggs"
    },
    {
      "name": "Young Hye Kim"
    },
    {
      "name": "Jaehoon Kim"
    },
    {
      "name": "Bernhard Dichtl"
    },
    {
      "name": "Vincent Geli"
    }
  ],
  "bibtex": "https://research.draconitic.com/paper/72wgscv5g14k8.bib",
  "cited_by": 0,
  "doi": "10.7554/elife.109886",
  "fulltext_url": null,
  "id": "72wgscv5g14k8",
  "issns": [
    "2050-084X"
  ],
  "landing_url": "https://hal.science/hal-05855054v1",
  "language": "en",
  "licence": "CC-BY-4.0",
  "licence_label": "CC BY 4.0",
  "licence_source": "article",
  "licence_url": "https://creativecommons.org/licenses/by/4.0/",
  "metadata_licence": null,
  "native_subjects": [
    [
      "hal",
      "0.sdv"
    ],
    [
      "openalex",
      "1312|Genomics and Chromatin Dynamics"
    ]
  ],
  "openalex": "W4416821081",
  "pdf_url": "https://hal.science/hal-05855054/document",
  "pmcid": null,
  "pmid": null,
  "published": "2026-09-16",
  "publisher": "eLife Sciences Publication",
  "ris": "https://research.draconitic.com/paper/72wgscv5g14k8.ris",
  "sources": [
    {
      "first_seen": "2026-11-07T12:20:25Z",
      "native_id": "hal-05855054",
      "source": "hal",
      "url": "https://hal.science/hal-05855054v1"
    }
  ],
  "subjects": [
    {
      "field": "biochemistry",
      "origin": "openalex:1312|Genomics and Chromatin Dynamics",
      "subfield": "molecular-biology"
    }
  ],
  "title": "A systematic interactome of Saccharomyces cerevisiae SET1C expands its functional landscape and identifies candidate regulatory connections",
  "title_text": "A systematic interactome of Saccharomyces cerevisiae SET1C expands its functional landscape and identifies candidate regulatory connections",
  "type": "peer-reviewed",
  "updated_at": "2026-11-08T12:20:49Z",
  "url": "https://research.draconitic.com/paper/72wgscv5g14k8",
  "venue": "eLife",
  "versions": []
}