{
  "abstract": "Background: Serosurveys suggest widespread dengue virus (DENV) transmission in Africa but there is limited information on the temporal patterns of exposure.\n\nMethods: Using repeated cross-sectional serosurvey data, we estimated the prevalence and incidence of DENV infections in coastal Kenya over 20 years (1998–2018). Stored sera ( n = 8025), collected annually from an open longitudinal cohort of 1834 children aged 15 years and below, were screened for anti-DENV IgG antibodies.\n\nResults: We show that, of 8025 samples, 2287 (28.5%, 95% CI 27.5–29.5%) were seropositive for DENV IgG antibodies. Seroprevalence increased with age, from 2% among children aged below 1 year to 40% among those aged 9 to 10 years, and peaked during outbreak years. Among 1343 children who were seronegative at recruitment, the overall incidence (seroconversion) rate was 111.5 DENV infections per 1000 person-years (95% CI 102.5–121.2). The highest incidence occurred in 2013 at 439.7 infections per 1000 person-years (95% CI 375.1–515.5), coinciding with a large outbreak in coastal Kenya.\n\nConclusions: Our findings suggest long-term DENV exposure among children in coastal Kenya and highlight an urgent need for clinical surveillance to determine the associated health burden.",
  "abstract_shown": true,
  "affiliations": [],
  "article_type": null,
  "arxiv": null,
  "author_total": 15,
  "authors": [
    {
      "name": "Daisy Mugo"
    },
    {
      "name": "Henry K. Karanja",
      "orcid": "0000-0002-8249-6833"
    },
    {
      "name": "Benedict Orindi"
    },
    {
      "name": "John N. Gitonga"
    },
    {
      "name": "Kennedy Mwai"
    },
    {
      "name": "Doris K. Nyamwaya"
    },
    {
      "name": "Donwilliams O. Omuoyo"
    },
    {
      "name": "Anthony K. Nyamache"
    },
    {
      "name": "Barnes S. Kitsao"
    },
    {
      "name": "Jennifer N. Musyoki"
    },
    {
      "name": "Julianna Wambua"
    },
    {
      "name": "Edward Otieno",
      "orcid": "0000-0002-8014-7306"
    },
    {
      "name": "Lynette Isabella Ochola-Oyier"
    },
    {
      "name": "Philip Bejon",
      "orcid": "0000-0002-2135-7549"
    },
    {
      "name": "George M. Warimwe",
      "orcid": "0000-0002-4911-6333"
    }
  ],
  "bibtex": "https://research.draconitic.com/paper/72y3sb9s3assg.bib",
  "cited_by": 2,
  "doi": "10.1038/s43856-026-01973-0",
  "fulltext_url": null,
  "id": "72y3sb9s3assg",
  "issns": [
    "2730-664X"
  ],
  "landing_url": "https://www.nature.com/articles/s43856-026-01973-0",
  "language": null,
  "licence": "CC-BY-4.0",
  "licence_label": "CC BY 4.0",
  "licence_source": "article",
  "licence_url": "https://creativecommons.org/licenses/by/4.0",
  "metadata_licence": null,
  "native_subjects": [
    [
      "openalex",
      "2739|Mosquito-borne diseases and control"
    ]
  ],
  "openalex": "W7222536614",
  "pdf_url": "https://www.nature.com/articles/s43856-026-01973-0_reference.pdf",
  "pmcid": null,
  "pmid": null,
  "published": "2026-10-16",
  "publisher": "Springer Science and Business Media LLC",
  "ris": "https://research.draconitic.com/paper/72y3sb9s3assg.ris",
  "sources": [
    {
      "first_seen": "2026-10-30T12:17:53Z",
      "native_id": "10.1038/s43856-026-01973-0",
      "source": "crossref",
      "url": "https://www.nature.com/articles/s43856-026-01973-0"
    }
  ],
  "subjects": [
    {
      "field": "medicine",
      "origin": "openalex:2739|Mosquito-borne diseases and control",
      "subfield": "epidemiology-public-health"
    }
  ],
  "title": "Temporal trends of dengue exposure among children in coastal Kenya",
  "title_text": "Temporal trends of dengue exposure among children in coastal Kenya",
  "type": "peer-reviewed",
  "updated_at": "2026-10-30T12:17:53Z",
  "url": "https://research.draconitic.com/paper/72y3sb9s3assg",
  "venue": "Communications Medicine",
  "versions": []
}