{
  "abstract": "Methotrexate (MTX)-induced iatrogenic immunodeficiency-associated lymphoproliferative disorder (OIIA-LPD) usually presents as multiple pulmonary nodules or masses. However, we herein present a rare case demonstrating diffuse ground-glass opacities (GGOs). The patient was a 77-year-old woman with a history of rheumatoid arthritis and advanced gastric cancer. Because of the markedly elevated serum lactate dehydrogenase levels and diffuse GGOs on chest computed tomography, intravascular lymphoma was considered. A transbronchial lung cryobiopsy (TBLC) was performed to obtain tissue specimens for a histopathological evaluation, leading to a diffuse large B-cell lymphoma diagnosis after multidisciplinary discussions. To the best of our knowledge, this is the first report of MTX-induced OIIA-LPD diagnosed by TBLC.",
  "abstract_shown": true,
  "affiliations": [],
  "article_type": null,
  "arxiv": null,
  "author_total": 15,
  "authors": [
    {
      "name": "Tetsuya Fujii"
    },
    {
      "name": "Maki Asami-Noyama"
    },
    {
      "name": "Shuichiro Ohata"
    },
    {
      "name": "Keita Murakawa"
    },
    {
      "name": "Kazuki Hamada"
    },
    {
      "name": "Yoriyuki Murata"
    },
    {
      "name": "Keiji Oishi"
    },
    {
      "name": "Taiga Kobayashi"
    },
    {
      "name": "Yoshie Kunihiro"
    },
    {
      "name": "Tomoko Kondo-Furuya"
    },
    {
      "name": "Nobutaka Edakuni"
    },
    {
      "name": "Tomoyuki Kakugawa"
    },
    {
      "name": "Tsunahiko Hirano"
    },
    {
      "name": "Akira Hebisawa"
    },
    {
      "name": "Kazuto Matsunaga"
    }
  ],
  "bibtex": "https://research.draconitic.com/paper/7321ys4hmfa4p.bib",
  "cited_by": 1,
  "doi": "10.2169/internalmedicine.6755-25",
  "fulltext_url": "https://www.jstage.jst.go.jp/article/internalmedicine/65/21/65_6755-25/_article",
  "id": "7321ys4hmfa4p",
  "issns": [
    "1349-7235",
    "0918-2918"
  ],
  "landing_url": "https://www.jstage.jst.go.jp/article/internalmedicine/65/21/65_6755-25/_article",
  "language": null,
  "licence": "CC-BY-NC-ND",
  "licence_label": "CC BY-NC-ND",
  "licence_source": "journal",
  "licence_url": "https://creativecommons.org/licenses/by-nc-nd/4.0/",
  "metadata_licence": null,
  "native_subjects": [
    [
      "jstage-journal",
      "medicine/general"
    ],
    [
      "openalex",
      "2734|Lymphoma Diagnosis and Treatment"
    ]
  ],
  "openalex": "W7137345568",
  "pdf_url": "https://www.jstage.jst.go.jp/article/internalmedicine/advpub/0/advpub_6755-25/_pdf",
  "pmcid": null,
  "pmid": null,
  "published": "2026-11-01",
  "publisher": null,
  "ris": "https://research.draconitic.com/paper/7321ys4hmfa4p.ris",
  "sources": [
    {
      "first_seen": "2026-11-01T12:20:57Z",
      "native_id": "10.2169/internalmedicine.6755-25",
      "source": "jstage",
      "url": "https://www.jstage.jst.go.jp/article/internalmedicine/65/21/65_6755-25/_article"
    }
  ],
  "subjects": [
    {
      "field": "medicine",
      "origin": "openalex:2734|Lymphoma Diagnosis and Treatment",
      "subfield": "general"
    }
  ],
  "title": "Methotrexate-induced Other Iatrogenic Immunodeficiency-associated Lymphoproliferative Disorder with Diffuse Ground-glass Opacities Diagnosed Using a Cryobiopsy",
  "title_text": "Methotrexate-induced Other Iatrogenic Immunodeficiency-associated Lymphoproliferative Disorder with Diffuse Ground-glass Opacities Diagnosed Using a Cryobiopsy",
  "type": "peer-reviewed",
  "updated_at": "2026-11-03T12:20:33Z",
  "url": "https://research.draconitic.com/paper/7321ys4hmfa4p",
  "venue": "Internal Medicine",
  "versions": []
}