{
  "abstract": "Background and objectives: Joint discomfort and pain during physical activity are frequent conditions in healthy adults, which can lead to mobility limitations, with multiple consequences on health and quality of life. This study aimed to evaluate the effects of a food supplement which combines cartilage hydrolysate and a rosehip extract on knee pain and discomfort in physically active healthy adults, examining subgroups according to sex and menopausal status.\n\nMethods: In this randomized, double-blind, placebo-controlled trial, 138 participants received either 4 capsules/day of Chondractiv™ Move (CM, containing 1200 mg/day of hydrolyzed chicken cartilage and 380 mg/day of Rosa canina extract) or a placebo (maltodextrin) for 8 weeks. Activity-related knee pain was assessed on a 0-10 eVAS following a standardized single-leg step-down test (SLSD) and analyzed via an ANCOVA. Activity-related knee pain experienced during or after daily activities (0-100 eVAS), daily life pain (ICOAP questionnaire), knee function (KOOS questionnaire), quality of life (SF-12 questionnaire) and range of motion were also assessed throughout the intervention period.\n\nResults: Participants (39.9% men, 39.1% pre-menopausal women [PreMW] and 21.0% post-menopausal women [PostMW]) with a mean age of 46.4 years and a mean BMI of 24.4 kg/m2, practiced 5.6 hours of exercise per week on average. Knee pain after SLSD significantly decreased (p < 0.0001) during the intervention in both arms in the entire population (CM: −2.2; placebo: −2.4), but with no significant difference between arms (delta −0.2 [95%CI −1.1; 0.7], p > 0.05). However, exploratory analyses in PostMW showed that the change from baseline tended to be greater with CM versus placebo (−3.4 versus −1.2; delta 2.2 [95%CI −0.2;4.7], p = 0.0712). Further exploration indicated a benefit of CM over placebo on knee pain experienced during daily activities (entire cohort; p = 0.0255) and after activity (PostMW only; p = 0.0421), and in the Sport and recreation dimension of the KOOS (PostMW; p = 0.0381). Quality of life and range of motion evolved favorably, but with no between-arm difference.\n\nConclusions: After eight weeks of supplementation, CM did not demonstrate superiority over placebo for the primary endpoint (pain after SLSD) but exploratory analyses indicated clinically meaningful improvements in postmenopausal women, particularly. These findings require confirmation in further large-scale studies.\n\nClinical trial registration: ClinicalTrials.gov, identifier [NCT06714851].",
  "abstract_shown": true,
  "affiliations": [
    "Symrise (Diana SAS), Saint-Nolff, France",
    "Martin Bauer Nutraceuticals S.r.l., Rivalta di Torino, Italy",
    "CEN, Dijon, France"
  ],
  "article_type": "research article",
  "arxiv": null,
  "author_total": 8,
  "authors": [
    {
      "affs": [
        0
      ],
      "name": "Lionel Noah"
    },
    {
      "affs": [
        1
      ],
      "name": "Cynthia G. Suarez"
    },
    {
      "affs": [
        0
      ],
      "name": "Arnaud Jacquot"
    },
    {
      "affs": [
        1
      ],
      "name": "Ralf Spreemann"
    },
    {
      "affs": [
        2
      ],
      "name": "Christine Juhel"
    },
    {
      "affs": [
        2
      ],
      "name": "Florian Rigaudier"
    },
    {
      "affs": [
        0
      ],
      "name": "Etienne Guillocheau"
    },
    {
      "affs": [
        0
      ],
      "name": "Séverine Méance"
    }
  ],
  "bibtex": "https://research.draconitic.com/paper/73s7yydgapkg4.bib",
  "cited_by": 0,
  "doi": "10.3389/fspor.2026.1873793",
  "fulltext_url": "https://pmc.ncbi.nlm.nih.gov/articles/PMC13741622/",
  "id": "73s7yydgapkg4",
  "issns": [
    "2624-9367"
  ],
  "landing_url": "https://doi.org/10.3389/fspor.2026.1873793",
  "language": "en",
  "licence": "CC-BY-4.0",
  "licence_label": "CC BY 4.0",
  "licence_source": "article",
  "licence_url": "https://creativecommons.org/licenses/by/4.0/",
  "metadata_licence": null,
  "native_subjects": [
    [
      "heading",
      "Clinical Trial"
    ],
    [
      "openalex",
      "2745|Osteoarthritis Treatment and Mechanisms"
    ]
  ],
  "openalex": "W7223381768",
  "pdf_url": "https://www.frontiersin.org/journals/sports-and-active-living/articles/10.3389/fspor.2026.1873793/pdf",
  "pmcid": "PMC13741622",
  "pmid": "42997329",
  "published": "2026-10-23",
  "publisher": "Frontiers Media SA",
  "ris": "https://research.draconitic.com/paper/73s7yydgapkg4.ris",
  "sources": [
    {
      "first_seen": "2026-11-10T12:22:38Z",
      "native_id": "PMC13741622",
      "source": "pmc",
      "url": "https://doi.org/10.3389/fspor.2026.1873793"
    }
  ],
  "subjects": [
    {
      "field": "medicine",
      "origin": "openalex:2745|Osteoarthritis Treatment and Mechanisms",
      "subfield": "general"
    }
  ],
  "title": "Supplementation with cartilage hydrolysate and rosehip peel extract in physically active adults: main outcomes and exploratory findings of a randomized, placebo-controlled study on knee discomfort",
  "title_text": "Supplementation with cartilage hydrolysate and rosehip peel extract in physically active adults: main outcomes and exploratory findings of a randomized, placebo-controlled study on knee discomfort",
  "type": "peer-reviewed",
  "updated_at": "2026-11-10T12:22:38Z",
  "url": "https://research.draconitic.com/paper/73s7yydgapkg4",
  "venue": "Frontiers in Sports and Active Living",
  "versions": []
}