{
  "abstract": "Functional dyspepsia (FD) is a common gastrointestinal complaint. This double-blind, placebo-controlled trial aims to determine the efficacy of a six-herb formulation (digestive aid) as a complementary therapy for FD. FD was confirmed based on Rome-IV criteria. Fifty patients were randomly assigned to receive either the digestive aid or a matching placebo for eight weeks, in addition to standard treatment protocols for FD. Dyspepsia symptoms were evaluated using the Leeds Dyspepsia Questionnaire (LDQ). The primary outcome was to compare changes in epigastric pain scores between the two groups from baseline to the end of treatment. The study included 30 (60%) female participants with a mean age of 40.8 (± 7.5) years. The comparison of mean changes in epigastric pain (-1.80 (-2.10, -1.50)), retrosternal pain (-2.12 (-2.40, -1.84)), regurgitation (-0.72 (-1.00, -0.44)), nausea (-1.40 (-1.70, -1.10)), early satiety (-0.88 (-1.16, -0.60)), belching (-1.00 (-1.30, -0.70)), dysphagia (-0.52 (-0.74, -0.30)), and vomiting (-0.40 (-0.64, -0.16)) showed significant improvement in the intervention group from baseline to the end of treatment. While a decrease in all dyspepsia domain scores was observed in the placebo group over the study period, the changes were not statistically significant. Between-group comparisons of mean differences revealed a significantly greater decrease in epigastric pain (-1.48 (-1.90, -1.06)), retrosternal pain (-1.96 (-2.40, -1.52)), regurgitation (-0.60 (-0.96, -0.24)), nausea (-1.32 (-1.72, -0.92)), early satiety (-0.76 (-1.14, -0.38)), belching (-0.84 (-1.24, -0.44)), and dysphagia (-0.40 (-0.68, -0.12)) in the digestive aid group compared to the placebo. The new formulation was well-tolerated with no major side effects during short-term use. Digestive aid, as an adjunct to standard therapy, may help alleviate symptoms in FD.",
  "abstract_shown": true,
  "affiliations": [
    "Research Development Center, Sina Hospital, Tehran University of Medical Sciences, Tehran, IRN",
    "Department of Internal Medicine, Sina Hospital, Tehran, IRN",
    "Department of Disaster & Emergency Health, School of Public Health, Tehran University of Medical Sciences, Tehran, IRN"
  ],
  "article_type": "research article",
  "arxiv": null,
  "author_total": 6,
  "authors": [
    {
      "affs": [
        0
      ],
      "name": "Raika Jamali"
    },
    {
      "affs": [
        1
      ],
      "name": "Amirhossein Aflatoonian"
    },
    {
      "affs": [
        2
      ],
      "name": "Abbas Keshtkar"
    },
    {
      "affs": [
        0
      ],
      "name": "Bardia Jamali"
    },
    {
      "affs": [
        0
      ],
      "name": "Yasaman Zarinfar"
    },
    {
      "affs": [
        0
      ],
      "name": "Eelia Gholampour Dehaki"
    }
  ],
  "bibtex": "https://research.draconitic.com/paper/73x836d1pbhe0.bib",
  "cited_by": 0,
  "doi": "10.7759/cureus.117706",
  "fulltext_url": "https://pmc.ncbi.nlm.nih.gov/articles/PMC13745196/",
  "id": "73x836d1pbhe0",
  "issns": [
    "2168-8184"
  ],
  "landing_url": "https://doi.org/10.7759/cureus.117706",
  "language": "en",
  "licence": "CC-BY-4.0",
  "licence_label": "CC BY 4.0",
  "licence_source": "article",
  "licence_url": "https://creativecommons.org/licenses/by/4.0/",
  "metadata_licence": null,
  "native_subjects": [
    [
      "heading",
      "Gastroenterology"
    ],
    [
      "heading",
      "Integrative/Complementary Medicine"
    ],
    [
      "heading",
      "Internal Medicine"
    ],
    [
      "openalex",
      "2715|Gastrointestinal motility and disorders"
    ]
  ],
  "openalex": "W7221141308",
  "pdf_url": "https://www.cureus.com/articles/529338-digestive-aid-as-adjunctive-therapy-in-functional-dyspepsia-a-randomized-double-blind-placebo-controlled-clinical-trial.pdf",
  "pmcid": "PMC13745196",
  "pmid": "43004994",
  "published": "2026-10-09",
  "publisher": "Cureus Inc.",
  "ris": "https://research.draconitic.com/paper/73x836d1pbhe0.ris",
  "sources": [
    {
      "first_seen": "2026-11-11T12:22:47Z",
      "native_id": "PMC13745196",
      "source": "pmc",
      "url": "https://doi.org/10.7759/cureus.117706"
    },
    {
      "first_seen": "2026-11-12T15:22:43Z",
      "native_id": "MED:43004994",
      "source": "europepmc",
      "url": "https://europepmc.org/article/MED/43004994"
    }
  ],
  "subjects": [
    {
      "field": "medicine",
      "origin": "openalex:2715|Gastrointestinal motility and disorders",
      "subfield": "general"
    }
  ],
  "title": "Digestive Aid as Adjunctive Therapy in Functional Dyspepsia: A Randomized Double-Blind Placebo-Controlled Clinical Trial",
  "title_text": "Digestive Aid as Adjunctive Therapy in Functional Dyspepsia: A Randomized Double-Blind Placebo-Controlled Clinical Trial",
  "type": "peer-reviewed",
  "updated_at": "2026-11-13T12:20:50Z",
  "url": "https://research.draconitic.com/paper/73x836d1pbhe0",
  "venue": "Cureus",
  "versions": []
}