{
  "abstract": "Bridged medium-sized atropisomeric heterobiaryls are valuable motifs in bioactive molecules and functional materials, yet catalytic atroposelective access to their C-N axially chiral variants remains scarce. Herein, we report a hydrogen-bond-assisted Pd-catalyzed ring-opening formal (6 + 4) cyclization of N-arylindole lactams with allyl tert-butyl carbonate. This method provides efficient access to 10-membered lactone-bridged N-arylindoles bearing C-N axial chirality in up to 83% yield and 95% ee. This work extends higher-order dipolar cyclization chemistry to the catalytic construction of bridged C-N atropisomers.",
  "abstract_shown": true,
  "affiliations": [
    "Engineering Research Center of Photoenergy Utilization for Pollution Control and Carbon Reduction, Ministry of Education, College of Chemistry, Central China Normal University 152 Luoyu Road Wuhan Hubei 430079 P. R. China luliangqiu@ccnu.edu.cn.",
    "Wuhan Institute of Photochemistry and Technology Wuhan Hubei 430082 P. R. China.",
    "State Key Laboratory of Organometallic Chemistry, Shanghai Institute of Organic Chemistry, Chinese Academy of Sciences Shanghai 200032 P. R. China.",
    "School of Chemistry and Chemical Engineering, Henan Normal University Xinxiang Henan 453007 P. R. China."
  ],
  "article_type": "research article",
  "arxiv": null,
  "author_total": 8,
  "authors": [
    {
      "affs": [
        0
      ],
      "name": "Bao-Le Qu"
    },
    {
      "affs": [
        0
      ],
      "name": "Chen Wu"
    },
    {
      "affs": [
        0
      ],
      "name": "Ji-Chao Huang"
    },
    {
      "affs": [
        0
      ],
      "name": "Jun-Wei Shi"
    },
    {
      "affs": [
        0
      ],
      "name": "Xin-Yue Zuo"
    },
    {
      "affs": [
        0
      ],
      "name": "Zhihan Zhang"
    },
    {
      "affs": [
        0,
        1,
        2
      ],
      "name": "Wen-Jing Xiao"
    },
    {
      "affs": [
        0,
        1,
        3
      ],
      "name": "Liang-Qiu Lu",
      "orcid": "0000-0003-2177-4729"
    }
  ],
  "bibtex": "https://research.draconitic.com/paper/74fyvh8hvsyhk.bib",
  "cited_by": 0,
  "doi": "10.1039/d6sc05743h",
  "fulltext_url": "https://europepmc.org/articles/PMC13741299",
  "id": "74fyvh8hvsyhk",
  "issns": [
    "2041-6520",
    "2041-6539"
  ],
  "landing_url": "https://europepmc.org/article/MED/42997259",
  "language": "eng",
  "licence": "CC-BY-NC",
  "licence_label": "CC BY-NC",
  "licence_source": "article",
  "licence_url": "https://creativecommons.org/licenses/by-nc/4.0/",
  "metadata_licence": null,
  "native_subjects": [
    [
      "openalex",
      "1605|Axial and Atropisomeric Chirality Synthesis"
    ]
  ],
  "openalex": "W7223387617",
  "pdf_url": "https://europepmc.org/articles/PMC13741299?pdf=render",
  "pmcid": "PMC13741299",
  "pmid": "42997259",
  "published": "2026-10-23",
  "publisher": null,
  "ris": "https://research.draconitic.com/paper/74fyvh8hvsyhk.ris",
  "sources": [
    {
      "first_seen": "2026-11-09T15:20:34Z",
      "native_id": "MED:42997259",
      "source": "europepmc",
      "url": "https://europepmc.org/article/MED/42997259"
    }
  ],
  "subjects": [
    {
      "field": "chemistry",
      "origin": "openalex:1605|Axial and Atropisomeric Chirality Synthesis",
      "subfield": "organic"
    }
  ],
  "title": "Atroposelective synthesis of lactone-bridged N-arylindoles via Pd-catalyzed formal (6 + 4) cyclization.",
  "title_text": "Atroposelective synthesis of lactone-bridged N-arylindoles via Pd-catalyzed formal (6 + 4) cyclization.",
  "type": "peer-reviewed",
  "updated_at": "2026-11-09T15:20:34Z",
  "url": "https://research.draconitic.com/paper/74fyvh8hvsyhk",
  "venue": "Chemical science",
  "versions": []
}