{
  "abstract": "Background: Bilateral pallidal deep brain stimulation (GPi-DBS) is effective for dystonia. Long-term evolution of therapeutic benefit and emergence of parkinsonism have not been systematically characterized. Objectives: To assess 15-year dystonia outcomes and characterize parkinsonism after bilateral GPi-DBS. Methods: Dystonia severity and disability were evaluated at baseline,1, 3, and 15 years postoperatively with the Burke-Fahn-Marsden Dystonia Rating Scale (BFMDRS). Parkinsonism was assessed at last visit using the Movement Disorder Society-Unified Parkinson's Disease Rating Scale-Part III and freezing of gait (FoG) questionnaire. Results: Of 17 patients reassessed at 15 years, 41% maintained clinical benefit. Parkinsonism was observed in 94%, predominantly axial, with self-reported FoG in 67%. Higher baseline BFMDRS-Motor scores predicted last follow-up axial parkinsonism (R = 0.800, P < 0.001). Conclusions: Over 15 years, interindividual therapeutic benefit diverged while axial parkinsonism emerged in nearly all patients. These findings highlight the need for systematic long-term monitoring extending beyond dystonia control after GPi-DBS.",
  "abstract_shown": true,
  "affiliations": [],
  "article_type": null,
  "arxiv": null,
  "author_total": 18,
  "authors": [
    {
      "name": "Clément Desjardins"
    },
    {
      "name": "Cécilia Bonnet"
    },
    {
      "name": "Elena Moro"
    },
    {
      "name": "David Grabli"
    },
    {
      "name": "Valérie Fraix"
    },
    {
      "name": "Marie‐laure Welter"
    },
    {
      "name": "Laurent Vercueil"
    },
    {
      "name": "Soledad Navarro"
    },
    {
      "name": "Carine Karachi"
    },
    {
      "name": "Thibaud Charrier"
    },
    {
      "name": "Sylvie Raoul"
    },
    {
      "name": "Mathilde Guibourd de Luzinais"
    },
    {
      "name": "Emmanuel Cuny"
    },
    {
      "name": "Stéphan Chabardes"
    },
    {
      "name": "Pierre Burbaud"
    },
    {
      "name": "Dominique Guehl"
    },
    {
      "name": "Pascal Derkinderen"
    },
    {
      "name": "Marie Vidailhet"
    }
  ],
  "bibtex": "https://research.draconitic.com/paper/74g9hd9s0byg1.bib",
  "cited_by": 0,
  "doi": "10.1002/mds.70504",
  "fulltext_url": null,
  "id": "74g9hd9s0byg1",
  "issns": [
    "0885-3185",
    "1531-8257"
  ],
  "landing_url": "https://hal.sorbonne-universite.fr/hal-05737281v1",
  "language": "en",
  "licence": "CC-BY-4.0",
  "licence_label": "CC BY 4.0",
  "licence_source": "article",
  "licence_url": "https://creativecommons.org/licenses/by/4.0/",
  "metadata_licence": null,
  "native_subjects": [
    [
      "hal",
      "0.sdv"
    ],
    [
      "hal",
      "1.sdv.mhep"
    ],
    [
      "openalex",
      "2728|Neurological disorders and treatments"
    ]
  ],
  "openalex": "W7207636435",
  "pdf_url": "https://hal.sorbonne-universite.fr/hal-05737281/document",
  "pmcid": null,
  "pmid": null,
  "published": "2026-09-03",
  "publisher": "Wiley",
  "ris": "https://research.draconitic.com/paper/74g9hd9s0byg1.ris",
  "sources": [
    {
      "first_seen": "2026-10-30T12:17:27Z",
      "native_id": "hal-05737281",
      "source": "hal",
      "url": "https://hal.sorbonne-universite.fr/hal-05737281v1"
    }
  ],
  "subjects": [
    {
      "field": "medicine",
      "origin": "openalex:2728|Neurological disorders and treatments",
      "subfield": "neurology"
    }
  ],
  "title": "Fifteen‐Year Outcomes of Bilateral Pallidal Stimulation in Isolated Generalized Dystonia: Characterization of Therapeutic Response and Emergence of Parkinsonism",
  "title_text": "Fifteen‐Year Outcomes of Bilateral Pallidal Stimulation in Isolated Generalized Dystonia: Characterization of Therapeutic Response and Emergence of Parkinsonism",
  "type": "peer-reviewed",
  "updated_at": "2026-10-30T12:17:27Z",
  "url": "https://research.draconitic.com/paper/74g9hd9s0byg1",
  "venue": "Movement Disorders",
  "versions": []
}