{
  "abstract": "铁死亡是一种由铁依赖性磷脂过氧化驱动的调节性细胞死亡(regulated cell death，RCD)，细胞对铁死亡的敏感性由遗传背景、代谢状态、抗氧化防御及治疗压力共同决定。肿瘤蛋白p53(tumor protein p53，TP53)、KRAS原癌基因(KRAS proto-oncogene, GTPase，KRAS)和表皮生长因子受体(epidermal growth factor receptor，EGFR)等驱动基因可通过调控胱氨酸-谷氨酸反向转运系统(system Xc- )/谷胱甘肽(glutathione，GSH)/谷胱甘肽过氧化物酶4(glutathione peroxidase 4，GPX4)轴，以及铁死亡抑制蛋白1(ferroptosis suppressor protein 1，FSP1)等旁路防御，形成情境依赖性的铁死亡表型。p53的作用受应激程度和突变位点影响，KRAS突变相关的胱氨酸与脂质代谢依赖情况可根据Kelch样ECH相关蛋白1(Kelch-like ECH-associated protein 1，KEAP1)状态进一步分层，而EGFR突变型肿瘤的反应则随EGFR突变亚型、诱导靶点及EGFR酪氨酸激酶抑制剂(EGFR tyrosine kinase inhibitor，EGFR-TKI)的治疗状态而变化。铁死亡还可通过氧化应激、铁代谢、自噬、线粒体功能、炎症信号及营养代谢，与凋亡、坏死性凋亡、焦亡、铜死亡和双硫死亡发生串扰。肿瘤微环境中的免疫细胞、癌相关成纤维细胞和血管内皮细胞可通过细胞因子、代谢底物供应及细胞外囊泡介导的跨细胞调控，改变肿瘤细胞的铁死亡阈值。靶向以上共享调控节点，或将铁死亡诱导与靶向治疗、化学治疗及免疫治疗联合，在克服治疗耐受方面显示出临床潜力，但其转化仍受到正常组织毒性、预后预测及药效标志物不足、候选药物成药性欠佳和递送效率有限等因素制约。因此，铁死亡靶向治疗策略需综合驱动基因型、治疗状态、细胞类型和代谢微环境对患者进行分层，并提高干预的肿瘤选择性及可监测性。",
  "abstract_shown": true,
  "affiliations": [],
  "article_type": "research article",
  "arxiv": null,
  "author_total": 2,
  "authors": [
    {
      "name": "雨潇 李",
      "orcid": "0009-0000-4818-9832"
    },
    {
      "name": "永光 陶",
      "orcid": "0000-0003-2354-5321"
    }
  ],
  "bibtex": "https://research.draconitic.com/paper/74n86rkmdk743.bib",
  "cited_by": 0,
  "doi": "10.11817/j.issn.1672-7347.2026.260457",
  "fulltext_url": "https://pmc.ncbi.nlm.nih.gov/articles/PMC13710894/",
  "id": "74n86rkmdk743",
  "issns": [
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  "landing_url": "https://doi.org/10.11817/j.issn.1672-7347.2026.260457",
  "language": "zh",
  "licence": "CC-BY-NC-ND-4.0",
  "licence_label": "CC BY-NC-ND 4.0",
  "licence_source": "article",
  "licence_url": "https://creativecommons.org/licenses/by-nc-nd/4.0/",
  "metadata_licence": null,
  "native_subjects": [
    [
      "heading",
      "Commentary"
    ],
    [
      "openalex",
      "2740|Ferroptosis and cancer prognosis"
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  "openalex": "W7223856004",
  "pdf_url": null,
  "pmcid": "PMC13710894",
  "pmid": "42935189",
  "published": "2026-08-28",
  "publisher": "Central South University",
  "ris": "https://research.draconitic.com/paper/74n86rkmdk743.ris",
  "sources": [
    {
      "first_seen": "2026-10-31T12:21:46Z",
      "native_id": "PMC13710894",
      "source": "pmc",
      "url": "https://doi.org/10.11817/j.issn.1672-7347.2026.260457"
    }
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  "subjects": [
    {
      "field": "medicine",
      "origin": "openalex:2740|Ferroptosis and cancer prognosis",
      "subfield": "general"
    }
  ],
  "title": "从驱动基因突变到细胞死亡交互：肿瘤铁死亡调控网络与靶向治疗前景",
  "title_text": "从驱动基因突变到细胞死亡交互：肿瘤铁死亡调控网络与靶向治疗前景",
  "type": "peer-reviewed",
  "updated_at": "2026-10-31T12:21:46Z",
  "url": "https://research.draconitic.com/paper/74n86rkmdk743",
  "venue": "Journal of Central South University Medical Sciences",
  "versions": []
}