{
  "abstract": "毒品成瘾不仅涉及中枢奖赏系统功能异常，还伴随肠道微生态失衡。毒品滥用相关的菌群变化主要体现在群落组成、多样性和代谢功能等方面，并呈现物质特异性。研究发现，菌群及其代谢产物也可反向影响药物奖赏和觅药行为。运动作为一种非药物干预手段有助于成瘾者的戒断康复。适宜且持续的运动有助于促进部分产短链脂肪酸菌群富集，并改善菌群代谢功能，其效应与运动强度和干预周期等因素有关。运动可能通过调控肠道菌群实现对毒品成瘾的改善，主要途径如下：通过调节肠道菌群、改善肠屏障功能，减少内毒素易位，调节外周与中枢免疫反应，从而减轻神经炎症；重塑菌群代谢功能，通过短链脂肪酸、胰高血糖素样肽-1、YY肽及色氨酸代谢相关信号参与腹侧被盖区-伏隔核等奖赏环路的功能调节，减弱药物及其线索相关的异常奖赏反应；通过对菌群相关的神经营养、神经可塑性和神经递质调节影响前额叶皮质和海马相关功能，促进工作记忆、抑制控制等认知功能恢复，并缓解焦虑、抑郁等消极情绪。本文系统梳理了毒品滥用与肠道菌群失调的相互关联、运动诱导的菌群适应性改变及其参与成瘾干预的可能机制，并讨论现有研究局限及因果验证、多组学整合和个体化运动处方等未来研究方向，为运动戒毒机制研究和干预策略优化提供参考。",
  "abstract_shown": true,
  "affiliations": [],
  "article_type": "research article",
  "arxiv": null,
  "author_total": 4,
  "authors": [
    {
      "name": "帅雄 廖",
      "orcid": "0000-0001-7025-4776"
    },
    {
      "name": "雪强 王"
    },
    {
      "name": "庭然 张"
    },
    {
      "name": "炯 罗",
      "orcid": "0009-0006-2158-5804"
    }
  ],
  "bibtex": "https://research.draconitic.com/paper/74tyjjtqncjr9.bib",
  "cited_by": 0,
  "doi": "10.3724/zdxbyxb-2025-0859",
  "fulltext_url": "https://pmc.ncbi.nlm.nih.gov/articles/PMC13722843/",
  "id": "74tyjjtqncjr9",
  "issns": [
    "1008-9292"
  ],
  "landing_url": "https://doi.org/10.3724/zdxbyxb-2025-0859",
  "language": "zh",
  "licence": "CC-BY-NC-ND-4.0",
  "licence_label": "CC BY-NC-ND 4.0",
  "licence_source": "article",
  "licence_url": "https://creativecommons.org/licenses/by-nc-nd/4.0/",
  "metadata_licence": null,
  "native_subjects": [
    [
      "heading",
      "G804.7"
    ],
    [
      "heading",
      "Monographic Reports"
    ],
    [
      "heading",
      "a"
    ],
    [
      "openalex",
      "1312|Gut microbiota and health"
    ]
  ],
  "openalex": "W7212065441",
  "pdf_url": null,
  "pmcid": "PMC13722843",
  "pmid": "42722624",
  "published": "2026-09-09",
  "publisher": "Zhejiang University Press",
  "ris": "https://research.draconitic.com/paper/74tyjjtqncjr9.ris",
  "sources": [
    {
      "first_seen": "2026-11-04T12:21:35Z",
      "native_id": "PMC13722843",
      "source": "pmc",
      "url": "https://doi.org/10.3724/zdxbyxb-2025-0859"
    }
  ],
  "subjects": [
    {
      "field": "biochemistry",
      "origin": "openalex:1312|Gut microbiota and health",
      "subfield": "molecular-biology"
    }
  ],
  "title": "运动通过肠道菌群变化改善毒品成瘾的机制研究进展",
  "title_text": "运动通过肠道菌群变化改善毒品成瘾的机制研究进展",
  "type": "peer-reviewed",
  "updated_at": "2026-11-04T12:21:35Z",
  "url": "https://research.draconitic.com/paper/74tyjjtqncjr9",
  "venue": "Journal of Zhejiang University (Medical Sciences)",
  "versions": []
}