{
  "abstract": "Introduction: Contrast-associated acute kidney injury (CA-AKI) is a complication after peripheral endovascular interventions, but the value of the inflammatory burden index (IBI) in this setting is unknown.\n\nAim: To evaluate the association between pre-procedural IBI and CA-AKI after iliac artery intervention, compare its performance with other inflammatory indices, and examine its relationship with TASC II lesion complexity.\n\nMaterial and methods: This retrospective study included 417 patients treated between January 2020 and December 2025. IBI was calculated as C-reactive protein multiplied by the neutrophil-to-lymphocyte ratio. CA-AKI was defined as a serum creatinine increase of ≥ 0.5 mg/dl or ≥ 25% within 72 h. Receiver operating characteristic analysis, DeLong testing, multivariable logistic regression with multiple imputation, restricted cubic splines, and bootstrap validation were performed.\n\nResults: CA-AKI occurred in 70 (16.8%) patients. IBI showed the highest discrimination for CA-AKI (AUC = 0.857, 95% CI: 0.810–0.904), outperforming C-reactive protein, neutrophil-to-lymphocyte ratio, systemic immune-inflammation index, and aggregate index of systemic inflammation (all p < 0.001). At a cutoff of 40.6, sensitivity and specificity were 80.0% and 80.2%, respectively. Each doubling of IBI was independently associated with CA-AKI (adjusted OR = 3.19, 95% CI: 2.22–4.59; p < 0.001). The association was nonlinear (p for nonlinearity < 0.001). IBI was also independently associated with TASC II C–D lesions (adjusted OR per doubling 2.91, 95% CI: 2.29–3.71; p < 0.001).\n\nConclusions: Pre-procedural IBI was independently associated with CA-AKI and complex iliac lesion morphology and outperformed the other evaluated inflammatory indices. External validation is required before clinical implementation.",
  "abstract_shown": true,
  "affiliations": [
    "Department of Cardiology, Kartal Koşuyolu High Specialization Training and Research Hospital, Istanbul, Turkey"
  ],
  "article_type": "research article",
  "arxiv": null,
  "author_total": 10,
  "authors": [
    {
      "affs": [
        0
      ],
      "name": "Mustafa Ferhat Keten"
    },
    {
      "affs": [
        0
      ],
      "name": "Kadir Bıyıklı"
    },
    {
      "affs": [
        0
      ],
      "name": "Busra Guvendi Sengor"
    },
    {
      "affs": [
        0
      ],
      "name": "Seda Tanyeri Uzel"
    },
    {
      "affs": [
        0
      ],
      "name": "Mustafa Furkan Kılıçarslan"
    },
    {
      "affs": [
        0
      ],
      "name": "Ayşe Nur Küçük"
    },
    {
      "affs": [
        0
      ],
      "name": "Hasan Karaot"
    },
    {
      "affs": [
        0
      ],
      "name": "Azmican Kaya"
    },
    {
      "affs": [
        0
      ],
      "name": "Neşri Danışman"
    },
    {
      "affs": [
        0
      ],
      "name": "İsmail Balaban"
    }
  ],
  "bibtex": "https://research.draconitic.com/paper/74vdk002d0ym7.bib",
  "cited_by": 0,
  "doi": "10.5114/aic.2026.164982",
  "fulltext_url": "https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13721074/?tool=EBI",
  "id": "74vdk002d0ym7",
  "issns": [
    "1734-9338",
    "1897-4295"
  ],
  "landing_url": "https://europepmc.org/article/PMC/PMC13721074",
  "language": "eng",
  "licence": "CC-BY-NC-SA",
  "licence_label": "CC BY-NC-SA",
  "licence_source": "article",
  "licence_url": "https://creativecommons.org/licenses/by-nc-sa/4.0/",
  "metadata_licence": null,
  "native_subjects": [
    [
      "heading",
      "Original Paper"
    ],
    [
      "openalex",
      "2727|Acute Kidney Injury Research"
    ]
  ],
  "openalex": "W7214158911",
  "pdf_url": "https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13721074/pdf/?tool=EBI",
  "pmcid": "PMC13721074",
  "pmid": "42964676",
  "published": "2026-09-01",
  "publisher": "Termedia Publishing",
  "ris": "https://research.draconitic.com/paper/74vdk002d0ym7.ris",
  "sources": [
    {
      "first_seen": "2026-10-31T12:21:37Z",
      "native_id": "PMC:PMC13721074",
      "source": "europepmc",
      "url": "https://europepmc.org/article/PMC/PMC13721074"
    },
    {
      "first_seen": "2026-11-03T12:21:49Z",
      "native_id": "PMC13721074",
      "source": "pmc",
      "url": "https://doi.org/10.5114/aic.2026.164982"
    }
  ],
  "subjects": [
    {
      "field": "medicine",
      "origin": "openalex:2727|Acute Kidney Injury Research",
      "subfield": "general"
    }
  ],
  "title": "Inflammatory burden index and contrast-associated acute kidney injury after iliac artery endovascular intervention: association with renal injury and lesion complexity",
  "title_text": "Inflammatory burden index and contrast-associated acute kidney injury after iliac artery endovascular intervention: association with renal injury and lesion complexity",
  "type": "peer-reviewed",
  "updated_at": "2026-11-03T12:21:49Z",
  "url": "https://research.draconitic.com/paper/74vdk002d0ym7",
  "venue": "Postepy w kardiologii interwencyjnej = Advances in interventional cardiology",
  "versions": []
}