{
  "abstract": "Over the past decade, machine learning (ML) has established a transformative paradigm for investigating amyloidogenic polypeptides. Characterized by their propensity to form ordered, β-sheet-rich fibrillar aggregates, these polypeptides are centrally implicated in the pathogenesis of numerous neurodegenerative diseases, including Alzheimer’s disease (AD) and Parkinson’s disease (PD). This review systematically evaluates the application of ML across critical domains of amyloid investigation: sequence-based amyloidogenicity prediction, structural biology, inhibitor design, and amyloid-related clinical objectives. We further summarize the diverse array of ML architectures currently employed in amyloid research, spanning classical algorithms (e.g., support vector machines and random forests) to advanced deep learning frameworks, such as the transformer framework, protein language models (PLMs), etc. Additionally, we spotlight emerging frontiers, namely, the integration of ML with molecular dynamics (MD) simulations, the use of generative AI for de novo inhibitor design, etc., while addressing persistent bottlenecks in the field, including data standardization, model interpretability, and rigorous experimental validation for in silico predictions. Ultimately, this review serves as a foundational roadmap for emerging researchers and a definitive reference for established investigators operating at the intersection of artificial intelligence and amyloid biology.",
  "abstract_shown": true,
  "affiliations": [
    "Anyang Institute of Technology , , ,",
    "Henan Provincial Key Laboratory of Intelligent Rehabilitation Equipment , ,",
    "West China Tianfu Hospital, Sichuan University , , ,",
    "The First People’s Hospital of Shihezi City , ,",
    "Sichuan University , , ,",
    "West China Hospital , , ,"
  ],
  "article_type": "review article",
  "arxiv": null,
  "author_total": 5,
  "authors": [
    {
      "affs": [
        0,
        1
      ],
      "name": "Guocheng Zhang"
    },
    {
      "affs": [
        2
      ],
      "name": "Hairui Li"
    },
    {
      "affs": [
        3
      ],
      "name": "Xudong Zhen"
    },
    {
      "affs": [
        4
      ],
      "name": "Yang Liu",
      "orcid": "0000-0003-4535-4630"
    },
    {
      "affs": [
        5
      ],
      "name": "Libin Huang"
    }
  ],
  "bibtex": "https://research.draconitic.com/paper/74wtxnjnhqyna.bib",
  "cited_by": 0,
  "doi": "10.1021/acsomega.6c06653",
  "fulltext_url": "https://europepmc.org/articles/PMC13688577",
  "id": "74wtxnjnhqyna",
  "issns": [
    "2470-1343"
  ],
  "landing_url": "https://pubs.acs.org/acsodf/article/11/41/62296/5448170/Machine-Learning-in-Amyloidogenic-Polypeptide",
  "language": "eng",
  "licence": "CC-BY-NC-ND-4.0",
  "licence_label": "CC BY-NC-ND 4.0",
  "licence_source": "article",
  "licence_url": "https://creativecommons.org/licenses/by-nc-nd/4.0/",
  "metadata_licence": null,
  "native_subjects": [
    [
      "openalex",
      "2737|Alzheimer's disease research and treatments"
    ]
  ],
  "openalex": "W7221093107",
  "pdf_url": "https://pubs.acs.org/doi/pdf/10.1021/acsomega.6c06653",
  "pmcid": "PMC13688577",
  "pmid": "42923435",
  "published": "2026-10-09",
  "publisher": "American Chemical Society (ACS)",
  "ris": "https://research.draconitic.com/paper/74wtxnjnhqyna.ris",
  "sources": [
    {
      "first_seen": "2026-10-30T12:18:39Z",
      "native_id": "10.1021/acsomega.6c06653",
      "source": "crossref",
      "url": "https://pubs.acs.org/acsodf/article/11/41/62296/5448170/Machine-Learning-in-Amyloidogenic-Polypeptide"
    },
    {
      "first_seen": "2026-10-30T12:20:33Z",
      "native_id": "MED:42923435",
      "source": "europepmc",
      "url": "https://europepmc.org/article/MED/42923435"
    }
  ],
  "subjects": [
    {
      "field": "medicine",
      "origin": "openalex:2737|Alzheimer's disease research and treatments",
      "subfield": "physiology"
    }
  ],
  "title": "Machine Learning in Amyloidogenic Polypeptide Research: From Sequence Prediction to Drug Discovery",
  "title_text": "Machine Learning in Amyloidogenic Polypeptide Research: From Sequence Prediction to Drug Discovery",
  "type": "peer-reviewed",
  "updated_at": "2026-10-30T12:20:33Z",
  "url": "https://research.draconitic.com/paper/74wtxnjnhqyna",
  "venue": "ACS Omega",
  "versions": []
}