{
  "abstract": "Herpes simplex virus (HSV) is a highly prevalent neurotropic DNA virus that causes orolabial herpes, genital herpes, keratitis, neonatal infection, meningitis and encephalitis. HSV-1 and HSV-2 share epithelial entry, lytic replication, immune evasion, lifelong sensory-ganglion latency and periodic reactivation, yet they differ in typical transmission routes, anatomical recurrence and public-health burden. Rather than mechanically separating both viruses throughout, this review emphasizes shared HSV biology and highlights type-specific differences where they affect clinical interpretation or intervention design. We connect glycoprotein-mediated entry, receptor use, axonal transport, immune evasion and latency with mucocutaneous, ocular, neurologic, neonatal and genital disease. We then synthesize lessons from failed glycoprotein-D vaccine trials, multivalent and mRNA platforms, helicase-primase inhibitors, monoclonal antibodies, RNA-based approaches, genome editing and latency-directed strategies. A mechanism-guided HSV strategy should reduce acquisition, shedding and recurrence, prevent ocular, neurologic and neonatal complications, manage antiviral resistance and ultimately address latent infection.",
  "abstract_shown": true,
  "affiliations": [
    "Division of HIV/AIDS and Sex-Transmitted Virus Vaccines, Institute for Biological Product Control, National Institutes for Food and Drug Control, Beijing 102629, China.",
    "National Vaccine and Serum Institute (NVSI), Beijing 101111, China."
  ],
  "article_type": "review article",
  "arxiv": null,
  "author_total": 3,
  "authors": [
    {
      "affs": [
        0,
        1
      ],
      "name": "Chenhao Jiang"
    },
    {
      "affs": [
        0
      ],
      "name": "Jianhui Nie",
      "orcid": "0000-0002-1474-0427"
    },
    {
      "affs": [
        0
      ],
      "name": "Li Zhang",
      "orcid": "0000-0001-6198-4064"
    }
  ],
  "bibtex": "https://research.draconitic.com/paper/75dpseed5x8wh.bib",
  "cited_by": 0,
  "doi": "10.3390/v18101116",
  "fulltext_url": "https://europepmc.org/articles/PMC13709602",
  "id": "75dpseed5x8wh",
  "issns": [
    "1999-4915"
  ],
  "landing_url": "https://europepmc.org/article/MED/42944036",
  "language": "eng",
  "licence": "CC-BY",
  "licence_label": "CC BY",
  "licence_source": "article",
  "licence_url": "https://creativecommons.org/licenses/by/4.0/",
  "metadata_licence": null,
  "native_subjects": [
    [
      "openalex",
      "2713|Herpesvirus Infections and Treatments"
    ]
  ],
  "openalex": "W7221183262",
  "pdf_url": "https://europepmc.org/articles/PMC13709602?pdf=render",
  "pmcid": "PMC13709602",
  "pmid": "42944036",
  "published": "2026-10-09",
  "publisher": null,
  "ris": "https://research.draconitic.com/paper/75dpseed5x8wh.ris",
  "sources": [
    {
      "first_seen": "2026-10-30T12:22:24Z",
      "native_id": "MED:42944036",
      "source": "europepmc",
      "url": "https://europepmc.org/article/MED/42944036"
    }
  ],
  "subjects": [
    {
      "field": "medicine",
      "origin": "openalex:2713|Herpesvirus Infections and Treatments",
      "subfield": "epidemiology-public-health"
    }
  ],
  "title": "Herpes Simplex Virus: Molecular Pathogenesis, Type-Specific Disease Burden, and Advances in Prevention and Treatment.",
  "title_text": "Herpes Simplex Virus: Molecular Pathogenesis, Type-Specific Disease Burden, and Advances in Prevention and Treatment.",
  "type": "peer-reviewed",
  "updated_at": "2026-10-30T12:22:24Z",
  "url": "https://research.draconitic.com/paper/75dpseed5x8wh",
  "venue": "Viruses",
  "versions": []
}