{
  "abstract": "Chronic neuroinflammation following traumatic brain injury (TBI) increases the risk of affective disorders and early-onset dementias. Existing anti-inflammatory therapies are limited by systemic side effects with chronic use and by poor brain penetration of newer biologics. Cannabidiol (CBD), a non-euphorigenic phytocannabinoid with a favorable safety profile and multi-target neuroprotective actions, is a promising alternative. Using a songbird microlesion model of learned vocal recovery after targeted damage to the premotor nucleus HVC, we previously showed that systemic CBD (10 mg/kg/day) reduces vocal disruption, inflammatory cytokines, oxidative stress, and synaptic loss. Here we tested the hypothesis that these benefits involve astrocytes. CBD (10 mg/kg/day IM for 7 days) preserved astrocyte viability, attenuated injury-induced lysosomal stress, suppressed reactivity markers (C3, S100A10, aromatase), and upregulated key metabolic and antioxidant transcripts (glutamine synthetase and GCLM) across the interconnected song-control nuclei HVC, RA, and Area X. These changes were accompanied by reduced neuronal apoptosis in lesioned HVC. The results identify astrocyte-associated responses as a candidate cellular substrate of CBD’s circuit-wide protective effects and support its translational potential to mitigate secondary injury and communication deficits after TBI.",
  "abstract_shown": true,
  "affiliations": [
    "Department of Pharmacology and Toxicology, Brody School of Medicine at East Carolina University , , ,",
    "Department of Anatomy and Cell Biology, Brody School of Medicine and East Carolina Diabetes and Obesity Institute at East Carolina University , , ,"
  ],
  "article_type": "research article",
  "arxiv": null,
  "author_total": 3,
  "authors": [
    {
      "affs": [
        0
      ],
      "name": "Dylan A. Marshall"
    },
    {
      "affs": [
        1
      ],
      "name": "Karen A. Litwa"
    },
    {
      "affs": [
        0
      ],
      "name": "Ken Soderstrom"
    }
  ],
  "bibtex": "https://research.draconitic.com/paper/75nqnr8ge1mfd.bib",
  "cited_by": 0,
  "doi": "10.3389/fphar.2026.1972787",
  "fulltext_url": "https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13690509/?tool=EBI",
  "id": "75nqnr8ge1mfd",
  "issns": [
    "1663-9812"
  ],
  "landing_url": "https://europepmc.org/article/PMC/PMC13690509",
  "language": "eng",
  "licence": "CC-BY",
  "licence_label": "CC BY",
  "licence_source": "article",
  "licence_url": "https://creativecommons.org/licenses/by/4.0/",
  "metadata_licence": null,
  "native_subjects": [
    [
      "openalex",
      "2736|Cannabis and Cannabinoid Research"
    ]
  ],
  "openalex": "W7221188520",
  "pdf_url": "https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13690509/pdf/?tool=EBI",
  "pmcid": "PMC13690509",
  "pmid": null,
  "published": "2026-10-09",
  "publisher": "Frontiers Media SA",
  "ris": "https://research.draconitic.com/paper/75nqnr8ge1mfd.ris",
  "sources": [
    {
      "first_seen": "2026-10-30T12:20:00Z",
      "native_id": "PMC:PMC13690509",
      "source": "europepmc",
      "url": "https://europepmc.org/article/PMC/PMC13690509"
    },
    {
      "first_seen": "2026-10-30T12:20:06Z",
      "native_id": "10.3389/fphar.2026.1972787",
      "source": "crossref",
      "url": "https://www.frontiersin.org/articles/10.3389/fphar.2026.1972787/full"
    }
  ],
  "subjects": [
    {
      "field": "medicine",
      "origin": "openalex:2736|Cannabis and Cannabinoid Research",
      "subfield": "pharmacology-toxicology"
    }
  ],
  "title": "Cannabidiol preserves astrocyte viability and attenuates injury-induced glial stress responses across zebra finch song control nuclei",
  "title_text": "Cannabidiol preserves astrocyte viability and attenuates injury-induced glial stress responses across zebra finch song control nuclei",
  "type": "peer-reviewed",
  "updated_at": "2026-10-30T12:20:06Z",
  "url": "https://research.draconitic.com/paper/75nqnr8ge1mfd",
  "venue": "Frontiers in pharmacology",
  "versions": []
}