{
  "abstract": "Purpose\n\nThe white blood cell to hemoglobin ratio (WBC/Hb) shows potential in predicting the severity and poor prognosis of infectious diseases. However, the specific utility of WBC/Hb in acute lower respiratory tract infections caused by Pseudomonas aeruginosa (ALRTIs-PA) has not been fully elucidated. This study aimed to evaluate the diagnostic value of WBC/Hb for disease severity (ICU admission) and its prognostic value for 90-day mortality in patients with ALRTIs-PA.Patients and methods\n\nA retrospective study was conducted among patients with ALRTIs-PA admitted to the First Affiliated Hospital of Anhui Medical University from January 2020 to January 2024. Baseline demographics, clinical characteristics, and laboratory parameters were extracted from electronic medical records. Logistic regression analysis was used to identify independent risk factors for ICU admission. A Cox proportional hazards model was used to determine predictors of 90-day all-cause mortality, and significant variables were subsequently into a prognostic prediction model.Results\n\nA total of 549 patients were enrolled, of whom 301 (54.8%) ICU admission, and 72 (13.1%) died within 90 days. Multivariate logistic regression analysis identified WBC/Hb, total protein (TP), blood urea nitrogen (BUN), lactate dehydrogenase (LDH), and neutrophil to lymphocyte ratio (NLR) as independent risk factors for ICU admission. Receiver operating characteristic (ROC) curve showed the best predictive value of WBC/Hb. Multivariable Cox regression analysis identified WBC/Hb, along with NLR, TP, tracheotomy, tracheal intubation, mechanical ventilation, acute renal failure, and the number of antibiotics used, as independent risk factors for 90-day mortality in patients with ALRTIs-PA. Notably, WBC/Hb was the strongest predictor (HR =8.130, 95% CI: 3.852-17.157, P < 0.001) of mortality among all examined variables.Conclusion\n\nOur findings suggest that WBC/Hb represents a valuable predictor for ICU admission and 90-day mortality in patients with ALRTIs-PA.",
  "abstract_shown": true,
  "affiliations": [
    "Department of Respiratory and Critical Care Medicine, First Affiliated Hospital of Anhui Medical University, Hefei, Anhui Province, 230022, People's Republic of China.",
    "Key Laboratory of Respiratory Diseases Research and Medical Transformation of Anhui Province, First Affiliated Hospital of Anhui Medical University, Hefei, Anhui Province, 230022, People's Republic of China."
  ],
  "article_type": "research article",
  "arxiv": null,
  "author_total": 2,
  "authors": [
    {
      "affs": [
        0,
        1
      ],
      "name": "Mei Hong"
    },
    {
      "affs": [
        0,
        1
      ],
      "name": "Da-Wei Zhang"
    }
  ],
  "bibtex": "https://research.draconitic.com/paper/768t6h6vn9b3a.bib",
  "cited_by": 0,
  "doi": "10.2147/idr.s633573",
  "fulltext_url": "https://europepmc.org/articles/PMC13695924",
  "id": "768t6h6vn9b3a",
  "issns": [
    "1178-6973"
  ],
  "landing_url": "https://europepmc.org/article/MED/42928916",
  "language": "eng",
  "licence": "CC-BY-NC",
  "licence_label": "CC BY-NC",
  "licence_source": "article",
  "licence_url": "https://creativecommons.org/licenses/by-nc/4.0/",
  "metadata_licence": null,
  "native_subjects": [
    [
      "openalex",
      "2713|Sepsis Diagnosis and Treatment"
    ]
  ],
  "openalex": "W7223002798",
  "pdf_url": "https://europepmc.org/articles/PMC13695924?pdf=render",
  "pmcid": "PMC13695924",
  "pmid": "42928916",
  "published": "2026-10-21",
  "publisher": null,
  "ris": "https://research.draconitic.com/paper/768t6h6vn9b3a.ris",
  "sources": [
    {
      "first_seen": "2026-10-30T12:21:18Z",
      "native_id": "MED:42928916",
      "source": "europepmc",
      "url": "https://europepmc.org/article/MED/42928916"
    }
  ],
  "subjects": [
    {
      "field": "medicine",
      "origin": "openalex:2713|Sepsis Diagnosis and Treatment",
      "subfield": "epidemiology-public-health"
    }
  ],
  "title": "The Value of the White Blood Cell-to-Hemoglobin Ratio in Acute Lower Respiratory Tract Infections of Pseudomonas Aeruginosa.",
  "title_text": "The Value of the White Blood Cell-to-Hemoglobin Ratio in Acute Lower Respiratory Tract Infections of Pseudomonas Aeruginosa.",
  "type": "peer-reviewed",
  "updated_at": "2026-10-30T12:21:18Z",
  "url": "https://research.draconitic.com/paper/768t6h6vn9b3a",
  "venue": "Infection and drug resistance",
  "versions": []
}