{
  "abstract": "Background\n\nMortality risk stratification in acute myocardial infarction complicated by cardiogenic shock (AMI-CS) remains challenging with heterogeneous temporary mechanical circulatory support (tMCS) use. We developed and temporally validated the admission-based AMICS-ADMIT model and bedside score and benchmarked them against established scores.Methods\n\nThis retrospective single-centre study, reported according to TRIPOD+AI, included 479 consecutive patients with AMI-CS undergoing percutaneous coronary intervention (PCI) between January 2017 and July 2025. The primary endpoint was in-hospital mortality. AMICS-ADMIT was developed using multivariable logistic regression in the 2017-2022 cohort, internally evaluated by bootstrap resampling, and temporally validated in the 2023-2025 cohort. Missing data were multiply imputed. Performance was assessed using discrimination, calibration, and Brier scores. Benchmarking against CardShock, IABP-SHOCK II, and GRACE was restricted to temporal validation; tMCS-stratified performance was exploratory.Results\n\nIn-hospital mortality was 42.6% (204/479). The final model included age, left ventricular ejection fraction, prior cardiopulmonary resuscitation, estimated glomerular filtration rate, vasoactive-inotropic score, and ST-segment elevation status. The continuous model achieved AUCs of 0.809 (95% CI 0.764-0.855) in development and 0.834 (95% CI 0.769-0.899) in temporal validation, with Brier scores of 0.176 and 0.167 and favourable calibration. The bedside score achieved AUCs of 0.777 (95% CI 0.728-0.826) and 0.775 (95% CI 0.699-0.851), respectively, with stepwise mortality separation across predefined risk categories. Discrimination did not differ significantly from CardShock, IABP-SHOCK II, or GRACE.Conclusions\n\nAMICS-ADMIT showed stable temporal performance and clinically interpretable early risk stratification in contemporary PCI-treated AMI-CS. External multicentre validation is required before clinical implementation.",
  "abstract_shown": true,
  "affiliations": [
    "Philipps-Universität Marburg, Department of Cardiology, Angiology, and Intensive Care Medicine, Baldingerstraße, Marburg, 35043, Germany."
  ],
  "article_type": "research article",
  "arxiv": null,
  "author_total": 10,
  "authors": [
    {
      "affs": [
        0
      ],
      "name": "Klevis Mihali"
    },
    {
      "affs": [
        0
      ],
      "name": "Birgit Markus"
    },
    {
      "affs": [
        0
      ],
      "name": "Kornelia Neuner"
    },
    {
      "affs": [
        0
      ],
      "name": "Georgios Chatzis"
    },
    {
      "affs": [
        0
      ],
      "name": "Lukas Harbaum"
    },
    {
      "affs": [
        0
      ],
      "name": "Mykyta Fomin"
    },
    {
      "affs": [
        0
      ],
      "name": "Maryana Choukeir"
    },
    {
      "affs": [
        0
      ],
      "name": "Styliani Syntila"
    },
    {
      "affs": [
        0
      ],
      "name": "Bernhard Schieffer"
    },
    {
      "affs": [
        0
      ],
      "name": "Julian Kreutz"
    }
  ],
  "bibtex": "https://research.draconitic.com/paper/76gcjsg58jgmz.bib",
  "cited_by": 0,
  "doi": "10.1016/j.ijcha.2026.102029",
  "fulltext_url": "https://europepmc.org/articles/PMC13683238",
  "id": "76gcjsg58jgmz",
  "issns": [
    "2352-9067"
  ],
  "landing_url": "https://europepmc.org/article/MED/42908764",
  "language": "eng",
  "licence": "CC-BY",
  "licence_label": "CC BY",
  "licence_source": "article",
  "licence_url": "https://creativecommons.org/licenses/by/4.0/",
  "metadata_licence": null,
  "native_subjects": [
    [
      "openalex",
      "2204|Mechanical Circulatory Support Devices"
    ]
  ],
  "openalex": "W7221765625",
  "pdf_url": "https://europepmc.org/articles/PMC13683238?pdf=render",
  "pmcid": "PMC13683238",
  "pmid": "42908764",
  "published": "2026-10-14",
  "publisher": null,
  "ris": "https://research.draconitic.com/paper/76gcjsg58jgmz.ris",
  "sources": [
    {
      "first_seen": "2026-10-30T12:20:10Z",
      "native_id": "MED:42908764",
      "source": "europepmc",
      "url": "https://europepmc.org/article/MED/42908764"
    }
  ],
  "subjects": [
    {
      "field": "medicine",
      "origin": "journal-openalex:2705|Atrial Fibrillation Management and Outcomes",
      "subfield": "cardiovascular"
    }
  ],
  "title": "Mortality risk stratification in contemporary myocardial infarction-related cardiogenic shock: development of AMICS-ADMIT prediction model and benchmarking of established scores.",
  "title_text": "Mortality risk stratification in contemporary myocardial infarction-related cardiogenic shock: development of AMICS-ADMIT prediction model and benchmarking of established scores.",
  "type": "peer-reviewed",
  "updated_at": "2026-10-30T12:20:10Z",
  "url": "https://research.draconitic.com/paper/76gcjsg58jgmz",
  "venue": "International journal of cardiology. Heart & vasculature",
  "versions": []
}