{
  "abstract": "Post-translational modifications (PTMs) regulate multiple mechanisms associated with glioblastoma (GBM) therapy resistance, which remains a major challenge in GBM treatment. Some resistance mechanisms involve genetic heterogeneity, glioblastoma stem cells, the tumor microenvironment, autophagy, metabolic reprogramming, vascular adaptation, and altered transcriptional regulation. By regulating protein activity, stability, localization, interactions, and signaling, PTMs can influence several of these processes and affect treatment response. This review examines the roles of phosphorylation, ubiquitination and ubiquitin-like modifications, acetylation, methylation, and glycosylation in resistance to temozolomide, radiotherapy, and targeted therapies. We further discuss emerging PTMs, including lactylation, succinylation, and UFMylation, for which evidence linking individual modifications to therapeutic resistance ranges from direct resistance mechanisms to effects primarily associated with GBM biology. PTM crosstalk is also discussed in the context of DNA repair, redox homeostasis, metabolism, glioblastoma stem cell maintenance, and therapy response. Finally, we examine pharmacological targeting of PTM-regulating enzymes and pathways and the effects of natural bioactive compounds on PTM-dependent mechanisms.",
  "abstract_shown": true,
  "affiliations": [
    "Graduate Program in Biochemistry, Department of Biochemistry, Federal University of Santa Catarina",
    "Graduate Program in Cell and Developmental Biology, Department of Cell Biology, Embryology and Genetics, Federal University of Santa Catarina"
  ],
  "article_type": "review article",
  "arxiv": null,
  "author_total": 5,
  "authors": [
    {
      "affs": [
        0
      ],
      "name": "Tetsade Piermartiri"
    },
    {
      "affs": [
        1
      ],
      "name": "Ana Carolini Adriana da Matta"
    },
    {
      "affs": [
        1
      ],
      "name": "João Victor Krüger Pinto"
    },
    {
      "affs": [
        0
      ],
      "name": "Carla Inês Tasca"
    },
    {
      "affs": [
        1
      ],
      "name": "Cláudia Beatriz Nedel"
    }
  ],
  "bibtex": "https://research.draconitic.com/paper/76gz4cn8wxmhc.bib",
  "cited_by": 0,
  "doi": "10.3389/fonc.2026.1984427",
  "fulltext_url": "https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13717505/?tool=EBI",
  "id": "76gz4cn8wxmhc",
  "issns": [
    "2234-943X"
  ],
  "landing_url": "https://www.frontiersin.org/articles/10.3389/fonc.2026.1984427/full",
  "language": "eng",
  "licence": "CC-BY-4.0",
  "licence_label": "CC BY 4.0",
  "licence_source": "article",
  "licence_url": "https://creativecommons.org/licenses/by/4.0/",
  "metadata_licence": null,
  "native_subjects": [
    [
      "heading",
      "Review"
    ],
    [
      "openalex",
      "2716|Glioma Diagnosis and Treatment"
    ]
  ],
  "openalex": "W7222106553",
  "pdf_url": "https://www.frontiersin.org/journals/oncology/articles/10.3389/fonc.2026.1984427/pdf",
  "pmcid": "PMC13717505",
  "pmid": "42959706",
  "published": "2026-10-15",
  "publisher": "Frontiers Media SA",
  "ris": "https://research.draconitic.com/paper/76gz4cn8wxmhc.ris",
  "sources": [
    {
      "first_seen": "2026-10-30T12:20:13Z",
      "native_id": "10.3389/fonc.2026.1984427",
      "source": "crossref",
      "url": "https://www.frontiersin.org/articles/10.3389/fonc.2026.1984427/full"
    },
    {
      "first_seen": "2026-10-31T00:20:37Z",
      "native_id": "PMC:PMC13717505",
      "source": "europepmc",
      "url": "https://europepmc.org/article/PMC/PMC13717505"
    },
    {
      "first_seen": "2026-10-31T12:21:46Z",
      "native_id": "MED:42959706",
      "source": "europepmc",
      "url": "https://europepmc.org/article/MED/42959706"
    },
    {
      "first_seen": "2026-11-02T12:21:48Z",
      "native_id": "PMC13717505",
      "source": "pmc",
      "url": "https://doi.org/10.3389/fonc.2026.1984427"
    }
  ],
  "subjects": [
    {
      "field": "medicine",
      "origin": "openalex:2716|Glioma Diagnosis and Treatment",
      "subfield": "human-genetics"
    }
  ],
  "title": "Targeting post-translational modifications to overcome glioblastoma therapy resistance: emerging strategies and natural compounds",
  "title_text": "Targeting post-translational modifications to overcome glioblastoma therapy resistance: emerging strategies and natural compounds",
  "type": "peer-reviewed",
  "updated_at": "2026-11-02T12:21:48Z",
  "url": "https://research.draconitic.com/paper/76gz4cn8wxmhc",
  "venue": "Frontiers in Oncology",
  "versions": []
}