{
  "abstract": "Objectives: This study aimed to evaluate the effectiveness and safety of cefazolin versus antistaphylococcal penicillins (ASPs) in the treatment of methicillin-susceptible Staphylococcus aureus (MSSA) bacteraemia. Methods: This phase IV, retrospective, comparative-effectiveness, multicentre study used data extracted from the international TriNetX analytics platform. Eligible patients developed monomicrobial MSSA bacteraemia during hospitalisation between January 1, 2015, and December 31, 2025, and received treatment with either cefazolin or ASPs. The primary outcome was all-cause mortality within 90 days. Safety outcomes included Clostridioides difficile infection within 90 days and renal, liver, allergic, and haematological disorders within 30 days. Survival analyses were conducted after propensity score matching. Results: Among 110,275 patients with MSSA bacteraemia identified, 3,908 (3.5%) met the inclusion criteria. After propensity score matching, 1,954 patients were included in each group. Treatment with cefazolin was associated with significantly reduced all-cause mortality within 90 days (9.7% versus 14.7%; HR = 0.620 [0.515–0.748]). Among the safety outcomes, Clostridioides difficile infection occurred less frequently in the cefazolin group (4.9% versus 7.20%; HR = 0.631 [0.482–0.827]). Conclusion: This real-world evaluation using the international TriNetX database suggests that compared with ASPs, cefazolin is more effective and safer for the management of MSSA bacteraemia. Trial registration: NCT07186894",
  "abstract_shown": true,
  "affiliations": [],
  "article_type": null,
  "arxiv": null,
  "author_total": 9,
  "authors": [
    {
      "name": "Natesan Ramsamy"
    },
    {
      "name": "Maïa Simon"
    },
    {
      "name": "Isabelle Adam"
    },
    {
      "name": "Gema Hernandez"
    },
    {
      "name": "Sarah Williford"
    },
    {
      "name": "Olivier Denquin"
    },
    {
      "name": "Céline Pulcini"
    },
    {
      "name": "Nathalie Thilly"
    },
    {
      "name": "Benjamin Lefèvre"
    }
  ],
  "bibtex": "https://research.draconitic.com/paper/76vmhrqjaje9d.bib",
  "cited_by": 0,
  "doi": "10.1128/aac.01765-25",
  "fulltext_url": null,
  "id": "76vmhrqjaje9d",
  "issns": [
    "0066-4804",
    "1098-6596"
  ],
  "landing_url": "https://hal.science/hal-05756449v1",
  "language": "en",
  "licence": "CC-BY-NC-SA-4.0",
  "licence_label": "CC BY-NC-SA 4.0",
  "licence_source": "article",
  "licence_url": "https://creativecommons.org/licenses/by-nc-sa/4.0/",
  "metadata_licence": null,
  "native_subjects": [
    [
      "hal",
      "0.sdv"
    ],
    [
      "hal",
      "1.sdv.mhep"
    ],
    [
      "hal",
      "2.sdv.mhep.mi"
    ],
    [
      "openalex",
      "2725|Antimicrobial Resistance in Staphylococcus"
    ]
  ],
  "openalex": "W7212319949",
  "pdf_url": "https://hal.science/hal-05756449/document",
  "pmcid": null,
  "pmid": "42725960",
  "published": "2026-09-11",
  "publisher": "American Society for Microbiology",
  "ris": "https://research.draconitic.com/paper/76vmhrqjaje9d.ris",
  "sources": [
    {
      "first_seen": "2026-10-30T12:17:36Z",
      "native_id": "hal-05756449",
      "source": "hal",
      "url": "https://hal.science/hal-05756449v1"
    }
  ],
  "subjects": [
    {
      "field": "biology",
      "origin": "hal:0.sdv",
      "subfield": "general"
    },
    {
      "field": "medicine",
      "origin": "hal:2.sdv.mhep.mi",
      "subfield": "infectious-disease"
    }
  ],
  "title": "Effectiveness and safety of cefazolin vs antistaphylococcal penicillins for methicillin-susceptible Staphylococcus aureus bacteremia: a multicenter real-world evaluation using the international TriNetX database",
  "title_text": "Effectiveness and safety of cefazolin vs antistaphylococcal penicillins for methicillin-susceptible Staphylococcus aureus bacteremia: a multicenter real-world evaluation using the international TriNetX database",
  "type": "peer-reviewed",
  "updated_at": "2026-10-30T12:17:36Z",
  "url": "https://research.draconitic.com/paper/76vmhrqjaje9d",
  "venue": "Antimicrobial Agents and Chemotherapy",
  "versions": []
}