{
  "abstract": "The combination of electron-poor heterocycles and trifluoromethyl motifs is widely found in pharmaceuticals, making the development of methods for the simultaneous introduction of these two features highly desirable. Herein, we report a fast, acid-free, metal-free, photocatalyst-free, and operationally simple multicomponent approach for the trifluoroalkylation of electron-poor heterocycles under open-air conditions. The method relies on the ability of trifluoromethyl thianthrenium triflate to generate CF3 radicals and proceeds through a polarity-reversal cascade strategy employing electron-rich alkenes as linkers. A broad range of alkenes and heterocycles was evaluated, and the chemo-and regioselectivity of the process were thoroughly investigated. Furthermore, mechanistic studies revealed that multiple pathways contribute to the formation of the desired products.",
  "abstract_shown": true,
  "affiliations": [
    "Department of Organic Chemistry, University of Valencia, Avda. Vicent Andrés Estellés 22, Valencia, Spain, 46100-Burjasot"
  ],
  "article_type": null,
  "arxiv": null,
  "author_total": 5,
  "authors": [
    {
      "affs": [
        0
      ],
      "name": "María Jesús Cabrera-Afonso",
      "orcid": "0000-0002-3736-3206"
    },
    {
      "affs": [
        0
      ],
      "name": "Marcos Escolano"
    },
    {
      "affs": [
        0
      ],
      "name": "Irene García"
    },
    {
      "affs": [
        0
      ],
      "name": "María Sánchez-Roselló",
      "orcid": "0000-0003-0675-3153"
    },
    {
      "affs": [
        0
      ],
      "name": "Carlos del Pozo",
      "orcid": "0000-0002-0947-5999"
    }
  ],
  "bibtex": "https://research.draconitic.com/paper/76xb0xnbnp2b6.bib",
  "cited_by": 0,
  "doi": "10.26434/chemrxiv.15010758/v1",
  "fulltext_url": null,
  "id": "76xb0xnbnp2b6",
  "issns": [],
  "landing_url": "https://chemrxiv.org/doi/full/10.26434/chemrxiv.15010758/v1",
  "language": null,
  "licence": "CC-BY-NC-ND",
  "licence_label": "CC BY-NC-ND",
  "licence_source": "journal",
  "licence_url": "https://creativecommons.org/licenses/by-nc-nd/4.0/",
  "metadata_licence": null,
  "native_subjects": [
    [
      "openalex",
      "3003|Fluorine in Organic Chemistry"
    ]
  ],
  "openalex": "W7223106222",
  "pdf_url": "https://chemrxiv.org/doi/pdf/10.26434/chemrxiv.15010758/v1",
  "pmcid": null,
  "pmid": null,
  "published": "2026-10-21",
  "publisher": "American Chemical Society (ACS)",
  "ris": "https://research.draconitic.com/paper/76xb0xnbnp2b6.ris",
  "sources": [
    {
      "first_seen": "2026-10-30T12:17:24Z",
      "native_id": "10.26434/chemrxiv.15010758",
      "source": "chemrxiv",
      "url": "https://chemrxiv.org/doi/full/10.26434/chemrxiv.15010758/v1"
    }
  ],
  "subjects": [
    {
      "field": "medicine",
      "origin": "openalex:3003|Fluorine in Organic Chemistry",
      "subfield": "pharmacology-toxicology"
    }
  ],
  "title": "Photocatalyst-Free Visible-Light-Induced Trifluoroalkylation of Electron-Deficient Heteroaromatics via a Three-Component Minisci-Type Reaction.",
  "title_text": "Photocatalyst-Free Visible-Light-Induced Trifluoroalkylation of Electron-Deficient Heteroaromatics via a Three-Component Minisci-Type Reaction.",
  "type": "preprint",
  "updated_at": "2026-10-30T12:17:24Z",
  "url": "https://research.draconitic.com/paper/76xb0xnbnp2b6",
  "venue": "ChemRxiv",
  "versions": []
}