{
  "abstract": "Extracellular vesicles (EVs) are nano-sized vesicles secreted by living cells and ubiquitously present in body fluids. They carry molecular cargo-including proteins, nucleic acids, and lipids-that accurately mirrors the physiological and pathological state of their parent cells, offering a highly promising novel source of biomarkers for liquid biopsy. This review systematically summarizes the progress in biomarker discovery and application of EVs in major diseases such as cancer, neurological disorders, and cardiovascular diseases. It provides an in-depth analysis of the key technical bottlenecks in current EV isolation, characterization, and detection methodologies, and discusses the challenges related to standardization and clinical translation. Finally, the review outlines the broad future prospects in this field, including integrated multi-omics analysis based on EVs, and their potential for early diagnosis, real-time therapeutic monitoring, and prognostic assessment.",
  "abstract_shown": true,
  "affiliations": [
    "Department of General Medicine, The First People’s Hospital of Zunyi (Third Affiliated Hospital of Zunyi Medical University)",
    "Laboratory Medicine, Guizhou Aerospace Hospital",
    "Burn Department, The First Affiliated Hospital of Gannan Medical University",
    "Laboratory Medicine, The First Affiliated Hospital of Gannan Medical University"
  ],
  "article_type": "review",
  "arxiv": null,
  "author_total": 13,
  "authors": [
    {
      "affs": [
        0
      ],
      "name": "Wenlong Huang",
      "orcid": "0009-0000-6185-6206"
    },
    {
      "affs": [
        1
      ],
      "name": "Ming Zhao",
      "orcid": "0009-0008-7910-1977"
    },
    {
      "affs": [
        0
      ],
      "name": "Ling Li",
      "orcid": "0000-0002-1940-8693"
    },
    {
      "affs": [
        0
      ],
      "name": "Qun Chen"
    },
    {
      "affs": [
        0
      ],
      "name": "Mao Yang",
      "orcid": "0000-0001-5327-875X"
    },
    {
      "affs": [
        0
      ],
      "name": "Chun Zhou"
    },
    {
      "affs": [
        0
      ],
      "name": "Maoji Qi"
    },
    {
      "affs": [
        0
      ],
      "name": "Yanxia Wang"
    },
    {
      "affs": [
        0
      ],
      "name": "Liya Luo"
    },
    {
      "affs": [
        0
      ],
      "name": "Wanneng Liang"
    },
    {
      "affs": [
        2
      ],
      "name": "Zonghong Lai"
    },
    {
      "affs": [
        0
      ],
      "name": "Shenglan Pu"
    },
    {
      "affs": [
        3
      ],
      "name": "Defa Huang",
      "orcid": "0000-0002-8323-7585"
    }
  ],
  "bibtex": "https://research.draconitic.com/paper/77a34z0saz3ha.bib",
  "cited_by": 10,
  "doi": "10.3389/fimmu.2026.1853671",
  "fulltext_url": null,
  "id": "77a34z0saz3ha",
  "issns": [
    "1664-3224"
  ],
  "landing_url": "https://doi.org/10.3389/fimmu.2026.1853671",
  "language": "en",
  "licence": "CC-BY",
  "licence_label": "CC BY",
  "licence_source": "journal",
  "licence_url": "https://creativecommons.org/licenses/by/4.0/",
  "metadata_licence": null,
  "native_subjects": [
    [
      "openalex",
      "1312|Extracellular vesicles in disease"
    ]
  ],
  "openalex": "W7161641026",
  "pdf_url": "https://www.frontiersin.org/journals/immunology/articles/10.3389/fimmu.2026.1853671/pdf",
  "pmcid": "PMC13226172",
  "pmid": "42238597",
  "published": "2026-05-19",
  "publisher": "Frontiers Media",
  "ris": "https://research.draconitic.com/paper/77a34z0saz3ha.ris",
  "sources": [
    {
      "first_seen": "2026-11-04T13:21:07Z",
      "native_id": "W7161641026",
      "source": "openalex",
      "url": "https://doi.org/10.3389/fimmu.2026.1853671"
    }
  ],
  "subjects": [
    {
      "field": "biochemistry",
      "origin": "openalex:1312|Extracellular vesicles in disease",
      "subfield": "molecular-biology"
    }
  ],
  "title": "Extracellular vesicle biomarkers: current status and future perspectives as novel tools in liquid biopsy",
  "title_text": "Extracellular vesicle biomarkers: current status and future perspectives as novel tools in liquid biopsy",
  "type": "peer-reviewed",
  "updated_at": "2026-11-08T13:20:43Z",
  "url": "https://research.draconitic.com/paper/77a34z0saz3ha",
  "venue": "Frontiers in Immunology",
  "versions": []
}