{
  "abstract": "Prostate cancer (PCa) represents one of the leading causes of cancer-related mortality among men. The efficacy of its treatment is often compromised by chemotherapeutic toxicity and multidrug resistance, underscoring the urgent need to develop efficient and low-toxicity alternative therapeutic strategies. Homoharringtonine (HHT), a bioactive compound, has demonstrated clinical anticancer efficacy in hematologic malignancies. However, its role and underlying mechanisms in prostate cancer remain largely unclear. This study provides evidence that HHT suppresses prostate cancer cell proliferation and promotes cell cycle arrest by modulating the TNF/NF-κB and MAPK signaling pathways, indicating its potential as a promising natural drug candidate for PCa treatment.",
  "abstract_shown": true,
  "affiliations": [
    "NHC Key Lab of Reproduction Regulation, Shanghai Engineering Research Center of Reproductive Health Drug and Devices, Shanghai Institute for Biomedical and Pharmaceutical Technologies, Pharmacy School of Pharmaceutical Sciences Fudan University, Shanghai 200237, China",
    "Department of Pharmacology & Toxicology, Shanghai Institute for Biomedical and Pharmaceutical Technologies, Shanghai 200032, China"
  ],
  "article_type": "research article",
  "arxiv": null,
  "author_total": 9,
  "authors": [
    {
      "affs": [
        0,
        1
      ],
      "name": "Yuzhong Chen"
    },
    {
      "affs": [
        0,
        1
      ],
      "name": "Sisi Huang",
      "orcid": "0000-0003-0452-4461"
    },
    {
      "affs": [
        0,
        1
      ],
      "name": "Dongyan Huang"
    },
    {
      "affs": [
        0
      ],
      "name": "Yangtao Jin"
    },
    {
      "affs": [
        0,
        1
      ],
      "name": "Congcong Shao"
    },
    {
      "affs": [
        0,
        1
      ],
      "name": "Xin Su"
    },
    {
      "affs": [
        0,
        1
      ],
      "name": "Rongfu Yang"
    },
    {
      "affs": [
        0
      ],
      "name": "Juan Jiang"
    },
    {
      "affs": [
        0,
        1
      ],
      "name": "Jianhui Wu"
    }
  ],
  "bibtex": "https://research.draconitic.com/paper/77d31ggc07j7j.bib",
  "cited_by": 0,
  "doi": "10.3390/cells15191788",
  "fulltext_url": "https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13664184/?tool=EBI",
  "id": "77d31ggc07j7j",
  "issns": [
    "2073-4409"
  ],
  "landing_url": "https://europepmc.org/article/PMC/PMC13664184",
  "language": "eng",
  "licence": "CC-BY",
  "licence_label": "CC BY",
  "licence_source": "article",
  "licence_url": "https://creativecommons.org/licenses/by/4.0/",
  "metadata_licence": null,
  "native_subjects": [
    [
      "openalex",
      "2740|Prostate Cancer Treatment and Research"
    ]
  ],
  "openalex": "W7214970691",
  "pdf_url": "https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13664184/pdf/?tool=EBI",
  "pmcid": "PMC13664184",
  "pmid": null,
  "published": "2026-09-30",
  "publisher": "MDPI AG",
  "ris": "https://research.draconitic.com/paper/77d31ggc07j7j.ris",
  "sources": [
    {
      "first_seen": "2026-10-30T12:17:35Z",
      "native_id": "PMC:PMC13664184",
      "source": "europepmc",
      "url": "https://europepmc.org/article/PMC/PMC13664184"
    },
    {
      "first_seen": "2026-10-30T12:19:02Z",
      "native_id": "10.3390/cells15191788",
      "source": "crossref",
      "url": "https://www.mdpi.com/2073-4409/15/19/1788"
    }
  ],
  "subjects": [
    {
      "field": "biology",
      "origin": "issn:2073-4409",
      "subfield": "cell-biology"
    }
  ],
  "title": "Homoharringtonine Suppresses Prostate Cancer Progression Through Modulation of the TNF/NF-κB and MAPK Signaling Pathways",
  "title_text": "Homoharringtonine Suppresses Prostate Cancer Progression Through Modulation of the TNF/NF-κB and MAPK Signaling Pathways",
  "type": "peer-reviewed",
  "updated_at": "2026-10-30T12:19:02Z",
  "url": "https://research.draconitic.com/paper/77d31ggc07j7j",
  "venue": "Cells",
  "versions": []
}