{
  "abstract": "Bioorthogonal click chemistry was employed for the selective detection of VCAM-1 overexpression on inflamed endothelial cells using lanthanide-doped nanoparticles as near-infrared (NIR) probes. Neodymium/Ytterbium co-doped nanoparticles exhibited efficient and specific targeting following bioorthogonal conjugation, while preserving their characteristic NIR emission profile and thermal sensing capabilities. These results demonstrate the potential of this strategy for the selective recognition of inflammatory biomarkers without compromising the optical performance of the nanoprobes, paving the way for multifunctional platforms for inflammation imaging and nanothermometry.",
  "abstract_shown": true,
  "affiliations": [
    "Nanomaterials for BioImaging Group (nanoBIG), Faculty of Medicine, Department of Physiology, Universidad Autónoma de Madrid 28029 Madrid Spain",
    "Department of Chemistry in Pharmaceutical Sciences, Complutense University of Madrid E-28040 Madrid Spain",
    "Nanomaterials for BioImaging Group (nanoBIG), Faculty of Science, Department of Materials Physics, Universidad Autónoma de Madrid 28049 Madrid Spain",
    "Nanomaterials for BioImaging Group (nanoBIG), Faculty of Science, Department of Applied Physics, Universidad Autónoma de Madrid 28049 Madrid Spain",
    "Institute for Advanced Research in Chemical Sciences (IAdChem), Universidad Autónoma de Madrid 28049 Madrid Spain",
    "Instituto de Ciencia de Materiales Nicolás Cabrera, Universidad Autónoma de Madrid 28049 Madrid Spain",
    "Nanomaterials for BioImaging Group, Instituto Ramón y Cajal de, Investigación Sanitaria IRYCIS Ctra de Colmenar km 9300 28034 Madrid Spain"
  ],
  "article_type": "research article",
  "arxiv": null,
  "author_total": 11,
  "authors": [
    {
      "affs": [
        0
      ],
      "name": "Livia Didonè",
      "orcid": "0009-0003-1740-0836"
    },
    {
      "affs": [
        1,
        2
      ],
      "name": "Dongmei Qiu"
    },
    {
      "affs": [
        1
      ],
      "name": "Paula Gutiérrez González"
    },
    {
      "affs": [
        0
      ],
      "name": "Marta Román-Carmena"
    },
    {
      "affs": [
        3,
        4,
        5,
        6
      ],
      "name": "Emma Martín Rodríguez",
      "orcid": "0000-0002-2190-8312"
    },
    {
      "affs": [
        1,
        6
      ],
      "name": "Jorge Rubio Retama"
    },
    {
      "affs": [
        0,
        6
      ],
      "name": "M. Carmen Iglesias-de la Cruz"
    },
    {
      "affs": [
        2,
        4,
        5,
        6
      ],
      "name": "Dirk H. Ortgies",
      "orcid": "0000-0001-9693-6484"
    },
    {
      "affs": [
        2,
        4,
        5,
        6
      ],
      "name": "Daniel Jaque",
      "orcid": "0000-0002-3225-0667"
    },
    {
      "affs": [
        0,
        6
      ],
      "name": "Miriam Granado",
      "orcid": "0000-0001-9178-8822"
    },
    {
      "affs": [
        2
      ],
      "name": "Álvaro Artiga",
      "orcid": "0000-0001-9475-6367"
    }
  ],
  "bibtex": "https://research.draconitic.com/paper/77nbz9a0278cc.bib",
  "cited_by": 0,
  "doi": "10.1039/d6ra06790e",
  "fulltext_url": "https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13730391/?tool=EBI",
  "id": "77nbz9a0278cc",
  "issns": [
    "2046-2069"
  ],
  "landing_url": "https://europepmc.org/article/PMC/PMC13730391",
  "language": "eng",
  "licence": "CC-BY",
  "licence_label": "CC BY",
  "licence_source": "article",
  "licence_url": "https://creativecommons.org/licenses/by/4.0/",
  "metadata_licence": null,
  "native_subjects": [
    [
      "heading",
      "Chemistry"
    ],
    [
      "openalex",
      "2505|Luminescence Properties of Advanced Materials"
    ]
  ],
  "openalex": "W7225142326",
  "pdf_url": "https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13730391/pdf/?tool=EBI",
  "pmcid": "PMC13730391",
  "pmid": "42979302",
  "published": "2026-11-03",
  "publisher": "Royal Society of Chemistry",
  "ris": "https://research.draconitic.com/paper/77nbz9a0278cc.ris",
  "sources": [
    {
      "first_seen": "2026-11-04T15:20:46Z",
      "native_id": "PMC:PMC13730391",
      "source": "europepmc",
      "url": "https://europepmc.org/article/PMC/PMC13730391"
    },
    {
      "first_seen": "2026-11-07T12:22:57Z",
      "native_id": "PMC13730391",
      "source": "pmc",
      "url": "https://doi.org/10.1039/d6ra06790e"
    }
  ],
  "subjects": [
    {
      "field": "chemistry",
      "origin": "openalex:2505|Luminescence Properties of Advanced Materials",
      "subfield": "materials-polymers"
    }
  ],
  "title": "Click-chemistry targeting of inflammation using NIR-emitting lanthanide nanoparticles with preserved optical functionality",
  "title_text": "Click-chemistry targeting of inflammation using NIR-emitting lanthanide nanoparticles with preserved optical functionality",
  "type": "peer-reviewed",
  "updated_at": "2026-11-07T12:22:57Z",
  "url": "https://research.draconitic.com/paper/77nbz9a0278cc",
  "venue": "RSC advances",
  "versions": []
}