{
  "abstract": "Oral ulcers represent a prevalent mucosal disease with incompletely elucidated pathogenesis and a clinical deficiency in multifunctional therapeutics. This study investigates a food-derived peptide, RDP3, with tissue-penetrating capability, which significantly promotes repair of oral ulcer mucosal in vivo and in vitro in a low concentration (1 nM). This is the first time to report a food-origin peptide capable of accelerating oral ulcer mucosal repair. RDP3 can not only accelerate wound healing but also restore microbiome homeostasis. Mechanistically, RDP3 functions as a novel peptide-antagonist of the interleukin-2 receptor β subunit (IL-2Rβ; binding affinity KD = 0.99 μM). This interaction suppresses pathological PI3K signaling, thereby inhibiting NLRP3/GSDMD-mediated pyroptosis, reducing inflammation, and promoting mucosal regeneration. These findings position RDP3 as a promising multifunctional therapeutic candidate for oral ulcer treatment.",
  "abstract_shown": true,
  "affiliations": [
    "Key Laboratory of Chemistry in Ethnic Medicinal Resources & Key Laboratory of Natural Products Synthetic Biology of Ethnic Medicinal Endophytes, State Ethnic Affairs Commission & Ministry of Education, School of Ethnic Medicine, Yunnan Minzu University, Kunming, Yunnan, China",
    "Key Laboratory of Skin and Mucosal Injury Repair, Regeneration & Active Peptides of Yunnan Provincial Department of Education, Regenerative Medicine Research Center, Faculty of Basic Medical Science, Kunming Medical University, Kunming, Yunnan, China",
    "Yunnan Characteristic Plant Extraction Laboratory Co. Ltd., Kunming, Yunnan, China",
    "Key Laboratory of Skin and Mucosal Injury Repair, Regeneration & Active Peptides of Yunnan Provincial Department of Education, Regenerative Medicine Research Center, Faculty of Basic Medical Science, Kunming Medical University, Kunming, Yunnan, China. yangxinwang@kmmu.edu.cn",
    "Key Laboratory of Skin and Mucosal Injury Repair, Regeneration & Active Peptides of Yunnan Provincial Department of Education, Regenerative Medicine Research Center, Faculty of Basic Medical Science, Kunming Medical University, Kunming, Yunnan, China. liunaixin@kmmu.edu.cn",
    "Key Laboratory of Chemistry in Ethnic Medicinal Resources & Key Laboratory of Natural Products Synthetic Biology of Ethnic Medicinal Endophytes, State Ethnic Affairs Commission & Ministry of Education, School of Ethnic Medicine, Yunnan Minzu University, Kunming, Yunnan, China. wangying_814@163.com"
  ],
  "article_type": null,
  "arxiv": null,
  "author_total": 13,
  "authors": [
    {
      "affs": [
        0
      ],
      "name": "Junyuan Wang",
      "orcid": "0000-0001-6129-4063"
    },
    {
      "affs": [
        1
      ],
      "name": "Yuliu Yang"
    },
    {
      "affs": [
        1
      ],
      "name": "Zeqiong Ru"
    },
    {
      "affs": [
        1
      ],
      "name": "Yingyu Zhang",
      "orcid": "0000-0003-1159-7706"
    },
    {
      "affs": [
        1
      ],
      "name": "Xueying Xiong"
    },
    {
      "affs": [
        0
      ],
      "name": "Yujing Ding"
    },
    {
      "affs": [
        0
      ],
      "name": "Xin Yu"
    },
    {
      "affs": [
        0
      ],
      "name": "Mengfan Ma"
    },
    {
      "affs": [
        2
      ],
      "name": "Wenrou Su"
    },
    {
      "affs": [
        1
      ],
      "name": "Yihang Huang"
    },
    {
      "affs": [
        3
      ],
      "name": "Xinwang Yang",
      "orcid": "0000-0003-3210-8908"
    },
    {
      "affs": [
        4
      ],
      "name": "Naixin Liu",
      "orcid": "0000-0003-3253-3832"
    },
    {
      "affs": [
        5
      ],
      "name": "Ying Wang",
      "orcid": "0000-0003-2377-9101"
    }
  ],
  "bibtex": "https://research.draconitic.com/paper/77ncgbmw0gjys.bib",
  "cited_by": 13,
  "doi": "10.1038/s41536-026-00487-6",
  "fulltext_url": null,
  "id": "77ncgbmw0gjys",
  "issns": [
    "2057-3995"
  ],
  "landing_url": "https://doi.org/10.1038/s41536-026-00487-6",
  "language": "en",
  "licence": "CC-BY-NC-ND",
  "licence_label": "CC BY-NC-ND",
  "licence_source": "journal",
  "licence_url": "https://creativecommons.org/licenses/by-nc-nd/4.0/",
  "metadata_licence": null,
  "native_subjects": [
    [
      "openalex",
      "2742|Wound Healing and Treatments"
    ],
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      "openalex",
      "2746|Wound Healing and Treatments"
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  "pdf_url": "https://www.nature.com/articles/s41536-026-00487-6.pdf",
  "pmcid": "PMC13642947",
  "pmid": "42323320",
  "published": "2026-06-20",
  "publisher": "Nature Portfolio",
  "ris": "https://research.draconitic.com/paper/77ncgbmw0gjys.ris",
  "sources": [
    {
      "first_seen": "2026-10-30T13:26:56Z",
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      "url": "https://doi.org/10.1038/s41536-026-00487-6"
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  "subjects": [
    {
      "field": "medicine",
      "origin": "openalex:2746|Wound Healing and Treatments",
      "subfield": "surgery"
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  ],
  "title": "Food-derived peptide RDP3 mitigates pyroptosis to enhance oral mucosal repair via the IL-2Rβ/PI3K axis",
  "title_text": "Food-derived peptide RDP3 mitigates pyroptosis to enhance oral mucosal repair via the IL-2Rβ/PI3K axis",
  "type": "peer-reviewed",
  "updated_at": "2026-11-09T13:21:16Z",
  "url": "https://research.draconitic.com/paper/77ncgbmw0gjys",
  "venue": "npj Regenerative Medicine",
  "versions": []
}