{
  "abstract": "Fragment screening is widely used to provide useful starting points for drug discovery. There are many methods that are used today for conducting fragment‐based screens. and fragment libraries vary widely in size. In this perspective, I discuss the method that I use for fragment screening and the size of my fragment library, the reasons for these choices, and provide an example that illustrates the advantages.",
  "abstract_shown": true,
  "affiliations": [
    "Departments of Biochemistry, Pharmacology and Chemistry Vanderbilt University Nashville Tennessee USA"
  ],
  "article_type": "research article",
  "arxiv": null,
  "author_total": 1,
  "authors": [
    {
      "affs": [
        0
      ],
      "name": "Stephen W. Fesik",
      "orcid": "0000-0001-5957-6192"
    }
  ],
  "bibtex": "https://research.draconitic.com/paper/78cw7r927q8gf.bib",
  "cited_by": 0,
  "doi": "10.1002/cmdc.70503",
  "fulltext_url": "https://pmc.ncbi.nlm.nih.gov/articles/PMC13731922/",
  "id": "78cw7r927q8gf",
  "issns": [
    "1860-7179",
    "1860-7187"
  ],
  "landing_url": "https://doi.org/10.1002/cmdc.70503",
  "language": "en",
  "licence": "CC-BY-4.0",
  "licence_label": "CC BY 4.0",
  "licence_source": "article",
  "licence_url": "https://creativecommons.org/licenses/by/4.0/",
  "metadata_licence": null,
  "native_subjects": [
    [
      "heading",
      "Perspective"
    ],
    [
      "openalex",
      "3002|Computational Drug Discovery Methods"
    ]
  ],
  "openalex": "W7225244456",
  "pdf_url": "https://onlinelibrary.wiley.com/doi/pdfdirect/10.1002/cmdc.70503",
  "pmcid": "PMC13731922",
  "pmid": "42978231",
  "published": "2026-11-03",
  "publisher": null,
  "ris": "https://research.draconitic.com/paper/78cw7r927q8gf.ris",
  "sources": [
    {
      "first_seen": "2026-11-08T12:22:01Z",
      "native_id": "PMC13731922",
      "source": "pmc",
      "url": "https://doi.org/10.1002/cmdc.70503"
    }
  ],
  "subjects": [
    {
      "field": "chemistry",
      "origin": "openalex:3002|Computational Drug Discovery Methods",
      "subfield": "medicinal"
    }
  ],
  "title": "What Method and Library Size Is Best for Fragment Screening?",
  "title_text": "What Method and Library Size Is Best for Fragment Screening?",
  "type": "peer-reviewed",
  "updated_at": "2026-11-08T12:22:01Z",
  "url": "https://research.draconitic.com/paper/78cw7r927q8gf",
  "venue": "Chemmedchem",
  "versions": []
}