{
  "abstract": "Inspired by the ionic and amphiphilic motifs of antimicrobial peptides, this study designed several mixed-charge polyurethane (MCPU) copolymer hydrogels in which the cation/anion charge ratio (C/A = 1.0-1.3)serves as the single structural variable.Charge-ratio tuning produced four physically crosslinked networks covering a 20-fold range in tensile strength (σb = 5.15-104 kPa) and a qualitative shift in network dynamics: C/A1.2 was identified as the mechanical optimum (σb = 104 kPa, toughness = 867 kJ m -3 ) and C/A1.3 (σb = 5.15 kPa), the most compliant one, was the only composition with tan δ > 1 across 10 to 1 rad s -1 (1.02→1.84),demonstrating viscous-dominant behavior at low deformation rates.Further, the antibacterial testing shows that only C/A1.2 and C/A1.3 are efficient contact-active bactericidal agents against 10 6 CFU mL -1 of S. aureus.Yet stepwise biosafety screening, cytocompatibility, hemolysis, and subcutaneous infected-interface evaluation, selected C/A1.3 over the mechanical optimum, C/A1.2.Moreover, the acute S. aureus-infected full-thickness wound model reveals that C/A1.3 is comparable to a clinically used antibacterial wound gel (Prontosan), achieving 98.3% bacterial reduction, accelerated wound closure, and attenuated IL-6/TNF-α expression.Notably, C/A1.3 presented a faster early wound closure performance than Prontosan (≈58% versus ≈21% at day 4).This work presents a series of charge-ratio-tunable MCPU copolymer hydrogels and a stepwise screening strategy for antibacterial wound interface applications.",
  "abstract_shown": true,
  "affiliations": [],
  "article_type": null,
  "arxiv": null,
  "author_total": 1,
  "authors": [
    {
      "name": "Haoran Wang",
      "orcid": "0000-0003-3801-9885"
    }
  ],
  "bibtex": "https://research.draconitic.com/paper/78m3w3dhhxpw8.bib",
  "cited_by": 0,
  "doi": "10.26434/chemrxiv.15009689/v1",
  "fulltext_url": null,
  "id": "78m3w3dhhxpw8",
  "issns": [],
  "landing_url": "https://chemrxiv.org/doi/full/10.26434/chemrxiv.15009689/v1",
  "language": null,
  "licence": "CC-BY-NC-ND",
  "licence_label": "CC BY-NC-ND",
  "licence_source": "journal",
  "licence_url": "https://creativecommons.org/licenses/by-nc-nd/4.0/",
  "metadata_licence": null,
  "native_subjects": [
    [
      "openalex",
      "2742|Wound Healing and Treatments"
    ]
  ],
  "openalex": "W7214990470",
  "pdf_url": "https://chemrxiv.org/doi/pdf/10.26434/chemrxiv.15009689/v1",
  "pmcid": null,
  "pmid": null,
  "published": "2026-09-30",
  "publisher": "American Chemical Society (ACS)",
  "ris": "https://research.draconitic.com/paper/78m3w3dhhxpw8.ris",
  "sources": [
    {
      "first_seen": "2026-10-30T12:17:21Z",
      "native_id": "10.26434/chemrxiv.15009689",
      "source": "chemrxiv",
      "url": "https://chemrxiv.org/doi/full/10.26434/chemrxiv.15009689/v1"
    }
  ],
  "subjects": [
    {
      "field": "medicine",
      "origin": "openalex:2742|Wound Healing and Treatments",
      "subfield": "general"
    }
  ],
  "title": "Antimicrobial-Peptide-Inspired Mixed-Charge Polyurethane Copolymer Hydrogels: Charge-Ratio Design and Screening for Infected Wound Repair",
  "title_text": "Antimicrobial-Peptide-Inspired Mixed-Charge Polyurethane Copolymer Hydrogels: Charge-Ratio Design and Screening for Infected Wound Repair",
  "type": "preprint",
  "updated_at": "2026-10-30T12:17:21Z",
  "url": "https://research.draconitic.com/paper/78m3w3dhhxpw8",
  "venue": "ChemRxiv",
  "versions": []
}