{
  "abstract": "Background\n\nEarlier randomized controlled trials (RCTs) investigating the effects of prune on bone health provided inconsistent findings. This study aims to summarize the literature and elucidate the effect of prune on bone health.Methods\n\nIn February 2025, PubMed, Scopus, Web of Science, and Google Scholar were searched for RCTs. The review was submitted to PROSPERO (CRD420250655812) and conducted according to the PRISMA statement guidelines. RCTs on the effects of prune on bone health markers were included. Weighted mean difference (WMD) with 95% confidence interval was used to calculate the pooled effect size. Random effects model was used to pool data. Risk of bias was assessed with Cochrane RoB 2 and certainty with GRADE.Results\n\nSeven studies were included in the systematic review, of which six studies involving 558 participants contributed data to at least one meta-analysis. Prune consumption had no significant effect on BMD (WMD = 0.001 g/cm²; 95% CI: -0.005 to 0.007; I² = 0.0%) at various skeletal sites but significantly reduced tartrate-resistant acid phosphatase-5b (TRAP-5b) (WMD = -0.365 U/L; 95% CI: -0.636 to -0.095; I² = 65.1%). Prune had no significant effect on bone alkaline phosphatase, insulin-like growth factor-1, and procollagen type 1 N-terminal propeptide.Conclusion\n\nPrune consumption did not significantly affect BMD or bone formation biomarkers. Although prune intake was associated with reduced TRAP-5b, this biochemical finding did not translate into measurable BMD improvement, and its clinical relevance remains uncertain. Long-term RCTs are required to further clarify the effects of prune on clinically relevant bone outcomes across diverse populations.",
  "abstract_shown": true,
  "affiliations": [
    "Faculty of Life Sciences: Food, Nutrition and Health, University of Bayreuth, Kulmbach, Germany.",
    "Nutrition & Health Innovation Research Institute, School of Medical and Health Sciences, Edith Cowan University, Perth, WA, Australia.",
    "Department of Nutrition, Faculty of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran.",
    "Department of Epidemiology and Biostatistics, School of Health, Isfahan University of Medical Sciences, Isfahan, Iran.",
    "Isfahan Cardiovascular Research Center, Cardiovascular Research Institute, Isfahan University of Medical Sciences, Isfahan, Iran. f_haghighatdoost@yahoo.com."
  ],
  "article_type": "research article",
  "arxiv": null,
  "author_total": 6,
  "authors": [
    {
      "affs": [
        0
      ],
      "name": "Amirhossein Ataei Kachouei"
    },
    {
      "affs": [
        1
      ],
      "name": "Sana Farzam"
    },
    {
      "affs": [
        2
      ],
      "name": "Farzam Kamrani"
    },
    {
      "affs": [
        3
      ],
      "name": "Alireza Najimi"
    },
    {
      "affs": [
        0
      ],
      "name": "Aryan Hajian"
    },
    {
      "affs": [
        4
      ],
      "name": "Fahimeh Haghighatdoost"
    }
  ],
  "bibtex": "https://research.draconitic.com/paper/78mh6kb92vsvp.bib",
  "cited_by": 0,
  "doi": "10.1186/s12937-026-01377-9",
  "fulltext_url": "https://europepmc.org/articles/PMC13721365",
  "id": "78mh6kb92vsvp",
  "issns": [
    "1475-2891"
  ],
  "landing_url": "https://europepmc.org/article/MED/42958323",
  "language": "eng",
  "licence": "CC-BY-NC-ND",
  "licence_label": "CC BY-NC-ND",
  "licence_source": "article",
  "licence_url": "https://creativecommons.org/licenses/by-nc-nd/4.0/",
  "metadata_licence": null,
  "native_subjects": [
    [
      "heading",
      "Research"
    ],
    [
      "openalex",
      "2732|Bone health and osteoporosis research"
    ]
  ],
  "openalex": "W7172133984",
  "pdf_url": "https://europepmc.org/articles/PMC13721365?pdf=render",
  "pmcid": "PMC13721365",
  "pmid": "42958323",
  "published": "2026-08-01",
  "publisher": "BMC",
  "ris": "https://research.draconitic.com/paper/78mh6kb92vsvp.ris",
  "sources": [
    {
      "first_seen": "2026-10-31T12:21:29Z",
      "native_id": "MED:42958323",
      "source": "europepmc",
      "url": "https://europepmc.org/article/MED/42958323"
    },
    {
      "first_seen": "2026-11-03T12:22:04Z",
      "native_id": "PMC13721365",
      "source": "pmc",
      "url": "https://doi.org/10.1186/s12937-026-01377-9"
    }
  ],
  "subjects": [
    {
      "field": "medicine",
      "origin": "openalex:2732|Bone health and osteoporosis research",
      "subfield": "surgery"
    }
  ],
  "title": "Effects of prune on bone health; a systematic review and meta-analysis of clinical trials.",
  "title_text": "Effects of prune on bone health; a systematic review and meta-analysis of clinical trials.",
  "type": "peer-reviewed",
  "updated_at": "2026-11-03T12:22:04Z",
  "url": "https://research.draconitic.com/paper/78mh6kb92vsvp",
  "venue": "Nutrition journal",
  "versions": []
}