{
  "abstract": "BACKGROUND: Maintaining antipsychotic therapy in psychosis is important in preventing relapse. Long-acting depot preparations can prevent covert non-adherence and thus potentially contribute to better patient outcomes. In this observational survey the main objective is to evaluate medication adherence and its determinants for oral treatment in a large sample of patients with psychosis. METHODS: In this cross-sectional survey medication adherence for oral treatment was assessed by patients using the patient-rated Medication Adherence Questionnaire (MAQ). Data were collected by physicians on patients with a recent acute psychotic episode before switching to long-acting injectable risperidone. Other evaluations included disease severity (Clinical Global Impression - Severity), patients' insight (Positive and Negative Syndrome Scale item G12), treatment acceptance (clinician-rated Compliance Rating Scale), and therapeutic alliance (patient-rated 4-Point ordinal Alliance Scale). RESULTS: A total of 399 psychiatrists enrolled 1,887 patients (mean age 36.8±11.9 years; 61.6% had schizophrenia). Adherence to oral medication was \"low\" in 53.2% of patients, \"medium\" in 29.5%, and \"high\" in 17.3%. Of patients with psychiatrist-rated active acceptance of treatment, 70% had \"medium\" or \"high\" MAQ scores (P<0.0001). Medication adherence was significantly associated with therapeutic alliance (4-Point ordinal Alliance Scale score; P<0.0001). Patient age was significantly associated with adherence: mean age increased with greater adherence (35.6, 36.7, and 38.6 years for patients with \"low\", \"medium\", and \"high\" levels of adherence, respectively; P=0.0007), while age <40 years was associated with \"low\" MAQ classification (P=0.0003). Poor adherence was also associated with a diagnosis of schizophrenia (P=0.0083), more severe disease (Clinical Global Impression - Severity ≥4; P<0.0001), and lower insight (Positive and Negative Syndrome Scale-G12 ≥4; P<0.0001). CONCLUSION: Self-reported adherence was low in most patients, with a strong positive association between self-reported adherence and psychiatrists' assessment of treatment acceptance. Understanding factors associated with poor medication adherence may help physicians to better manage their patients, thereby improving outcomes.",
  "abstract_shown": true,
  "affiliations": [],
  "article_type": null,
  "arxiv": null,
  "author_total": 4,
  "authors": [
    {
      "name": "David Misdrahi"
    },
    {
      "name": "Franck Baylé"
    },
    {
      "name": "Arnaud Tessier"
    },
    {
      "name": "Sophie Bouju"
    }
  ],
  "bibtex": "https://research.draconitic.com/paper/78nt2psncmaq1.bib",
  "cited_by": 18,
  "doi": "10.2147/ppa.s89748",
  "fulltext_url": null,
  "id": "78nt2psncmaq1",
  "issns": [
    "1177-889X"
  ],
  "landing_url": "https://u-bordeaux.hal.science/hal-05801515v1",
  "language": "en",
  "licence": "CC-BY-NC",
  "licence_label": "CC BY-NC",
  "licence_source": "journal",
  "licence_url": "https://creativecommons.org/licenses/by-nc/4.0/",
  "metadata_licence": null,
  "native_subjects": [
    [
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      "openalex",
      "2714|Medication Adherence and Compliance"
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  "openalex": "W1664187253",
  "pdf_url": "https://www.dovepress.com/getfile.php?fileID=27062",
  "pmcid": null,
  "pmid": null,
  "published": "2026-10-15",
  "publisher": "Dovepress",
  "ris": "https://research.draconitic.com/paper/78nt2psncmaq1.ris",
  "sources": [
    {
      "first_seen": "2026-10-30T12:17:57Z",
      "native_id": "hal-05801515",
      "source": "hal",
      "url": "https://u-bordeaux.hal.science/hal-05801515v1"
    }
  ],
  "subjects": [
    {
      "field": "biology",
      "origin": "hal:1.scco.neur",
      "subfield": "neuroscience"
    },
    {
      "field": "medicine",
      "origin": "hal:2.sdv.mhep.psm",
      "subfield": "psychiatry"
    }
  ],
  "title": "Medication adherence in patients with psychotic disorders: an observational survey involving patients before they switch to long-acting injectable risperidone",
  "title_text": "Medication adherence in patients with psychotic disorders: an observational survey involving patients before they switch to long-acting injectable risperidone",
  "type": "peer-reviewed",
  "updated_at": "2026-10-30T12:17:57Z",
  "url": "https://research.draconitic.com/paper/78nt2psncmaq1",
  "venue": "Patient Preference and Adherence",
  "versions": []
}