{
  "abstract": "Background The benefit of surgical resection in addition to systemic therapy in patients with gastric/gastroesophageal cancer and peritoneal metastases (GCPM) is controversial. This CONVERGENCE trial aims to study the potential benefits of conversion surgery in patients with peritoneal metastases. Methods This is a prospective, pragmatically designed, multicentre, randomized, investigator-initiated phase II/III trial. Patients with synchronous GCPM who have undergone either systemic therapy (including 1 L chemotherapy +/- targeted therapy +/- immunotherapy) +/- peritoneal directed chemotherapy with favourable response would be randomized in 1:1 ratio to Arm 1 (Conversion surgery followed by systemic +/- peritoneal directed chemotherapy or Arm 2 (continual systemic +/- peritoneal directed chemotherapy). In the initial Phase II trial, 136 patients will be recruited and randomized. The primary endpoint is overall survival; main secondary endpoints include progression-free survival, R0 resection and complete cytoreduction rates, surgical morbidity/mortality and quality of life outcomes. If pre-defined thresholds of improved overall survival are met, the trial will expand to adequately power a phase III randomized controlled trial (n = 300). Discussion If survival benefit in conversion gastrectomy is demonstrated, this could potentially be a new standard of care for patients with peritoneal metastases from gastric or gastroesophageal junction cancer. Conversely, negative findings may lead to the avoidance of unnecessary surgical procedures and morbidity in these patients. Trial registration NCT07241715.",
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  "affiliations": [
    "Department of Surgery, University Surgical Cluster, National University Health System",
    "Saw Swee Hock School of Public Health, National University of Singapore",
    "Department of Surgery, Yong Loo Lin School of Medicine, National University of Singapore C/O NUHS Tower Block Level 8",
    "MD Andersen Cancer Center",
    "Verona University Hospital",
    "Imperial College Trials Unit-Cancer, Hammersmith Hospital, Imperial College Healthcare NHS Trust",
    "Department of General, Visceral and Transplantation Surgery, Heidelberg University Hospital",
    "The Chinese University of Hong Kong",
    "University Hospital Viamed Santa Elena",
    "Peter MacCallum Cancer Center",
    "Trinity St. James’s Cancer Institute",
    "University of Lille Centre Hospital",
    "Hospital Clínico Universitario of Valencia",
    "Amsterdam UMC location University of Amsterdam",
    "Heidelberg University Hospital",
    "Nihon University Hospital",
    "Catharina Hospital Eindhoven",
    "Yonsei University Hospital",
    "University Medical Center at Ho Chi Minh City",
    "The University of Hong Kong, Queen Mary Hospital",
    "Seoul National University Hospital",
    "Oxford University Hospital",
    "European Georges Pompidou Hospital",
    "National Cancer Centre, Singapore General Hospital",
    "Medical High School Hannover (MHH)",
    "Charité university school of Berlin",
    "Antoni van Leeuwenhoek Hospital, Netherlands Cancer Institute in Amsterdam",
    "Montpellier Cancer Hospital",
    "National Cancer Institute Mexico City",
    "Erasmus University Medical Center",
    "City of Hope Hospital",
    "Lyon University Centre Hospital",
    "Department of Clinical Science, Intervention and Technology, Department of Upper Abdominal Diseases, Karolinska Institutet, Karolinska University Hospital",
    "Department of Haematology-Oncology, National University Cancer Institute, NUHS Tower Block, Level 7"
  ],
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      "name": "Daryl KA Chia"
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  "bibtex": "https://research.draconitic.com/paper/79gw9fp4v8t3y.bib",
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  "doi": "10.1186/s12885-026-16423-2",
  "fulltext_url": "https://doi.org/10.1186/s12885-026-16423-2",
  "id": "79gw9fp4v8t3y",
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  "language": "en",
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  "published": "2026-07-01",
  "publisher": "BMC",
  "ris": "https://research.draconitic.com/paper/79gw9fp4v8t3y.ris",
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  ],
  "title": "The CONVERGENCE trial protocol: a phase II/III trial for conversion surgery for gastric cancer with peritoneal metastases",
  "title_text": "The CONVERGENCE trial protocol: a phase II/III trial for conversion surgery for gastric cancer with peritoneal metastases",
  "type": "peer-reviewed",
  "updated_at": "2026-10-31T14:20:46Z",
  "url": "https://research.draconitic.com/paper/79gw9fp4v8t3y",
  "venue": "BMC Cancer",
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