{
  "abstract": "Objective: Longitudinal investigation of brain alterations in children putatively at risk of developing schizophrenia may identify early markers of pathophysiology associated with vulnerability for the disorder.\n\nMethods: Children aged 9–12 years with multiple antecedents of schizophrenia (psychotic-like experiences; speech and/or motor delays; and social, emotional, and/or behavioral difficulties; ASz, n = 31), with a family history of schizophrenia/schizoaffective disorder (FHx, n = 21), and typically developing children (TD, n = 35) were recruited through community screening using questionnaires. T1-weighted structural MRI scans were obtained at baseline and after approximately 2 and 4 years of follow-up, and processed using the FreeSurfer longitudinal pipeline. Across these 3 assessment waves, total gray matter (GM) and white matter (WM) volume, and regional GM volumes in 12 regions of interest, were compared among the groups using linear mixed models.\n\nResults: Children were aged 11.21 (±1.61) years at baseline and the average lapse-of-time between each assessment was 1.76 (±0.36) years. The ASz group exhibited consistently higher total WM volume (b = 29.45) compared to the TD group, with no statistically significant time-related volumetric WM or GM differences in any region. The FHx group also demonstrated higher total WM volume (b = 36.49), and time-related total and regional GM volume changes were observed; however, these effects were attenuated after correction.\n\nConclusion: Global and regionally specific brain abnormalities distinguished children with different risk profiles for schizophrenia relative to their typically developing peers. Follow-up is required to determine how these changes may relate to later schizophrenia.",
  "abstract_shown": true,
  "affiliations": [
    "Department of Psychosis Studies, King’s College London, UK",
    "Center for AI and Data Science for Integrated Diagnostics, and Center for Biomedical Image Computing and Analytics,University of Pennsylvania, USA",
    "Education & Training Division, Anna Freud Centre, UK",
    "Research Department of Clinical, Educational & Health Psychology, University College London, UK",
    "National Institute for Health Research (NIHR), Mental Health Biomedical Research Centre at South London and Maudsley NHS Foundation Trust and King’s College London, UK",
    "Division of Insurance Medicine, Department of Clinical Neuroscience, Karolinska Institutet, Sweden",
    "School of Psychology and Counselling, Queensland University of Technology (QUT), Australia",
    "Social, Genetic & Developmental Psychiatry Centre, King’s College London, UK"
  ],
  "article_type": "research article",
  "arxiv": null,
  "author_total": 7,
  "authors": [
    {
      "affs": [
        0
      ],
      "name": "Shuqing Si"
    },
    {
      "affs": [
        0
      ],
      "name": "Matthew Kempton"
    },
    {
      "affs": [
        0
      ],
      "name": "Emily Hedges"
    },
    {
      "affs": [
        1
      ],
      "name": "Mathilde Antoniades"
    },
    {
      "affs": [
        2,
        3
      ],
      "name": "Ruth E. Roberts"
    },
    {
      "affs": [
        0,
        4,
        5
      ],
      "name": "Alexis E. Cullen"
    },
    {
      "affs": [
        6,
        7
      ],
      "name": "Kristin R. Laurens",
      "orcid": "0000-0002-3987-6486"
    }
  ],
  "bibtex": "https://research.draconitic.com/paper/79ped08e5d2st.bib",
  "cited_by": 0,
  "doi": "10.1017/s1092852926101047",
  "fulltext_url": "https://pmc.ncbi.nlm.nih.gov/articles/PMC13732592/",
  "id": "79ped08e5d2st",
  "issns": [
    "1092-8529",
    "2165-6509"
  ],
  "landing_url": "https://doi.org/10.1017/s1092852926101047",
  "language": "en",
  "licence": "CC-BY-4.0",
  "licence_label": "CC BY 4.0",
  "licence_source": "article",
  "licence_url": "https://creativecommons.org/licenses/by/4.0/",
  "metadata_licence": null,
  "native_subjects": [
    [
      "heading",
      "Original Research"
    ],
    [
      "openalex",
      "2738|Schizophrenia research and treatment"
    ]
  ],
  "openalex": "W7164012012",
  "pdf_url": "https://www.cambridge.org/core/services/aop-cambridge-core/content/view/079846C16454B7F072A2095CA6BF086E/S1092852926101047a.pdf/div-class-title-trajectories-of-grey-and-white-matter-volume-in-children-at-elevated-risk-for-schizophrenia-div.pdf",
  "pmcid": "PMC13732592",
  "pmid": "42261052",
  "published": "2026-06-09",
  "publisher": "Cambridge University Press",
  "ris": "https://research.draconitic.com/paper/79ped08e5d2st.ris",
  "sources": [
    {
      "first_seen": "2026-11-08T12:22:33Z",
      "native_id": "PMC13732592",
      "source": "pmc",
      "url": "https://doi.org/10.1017/s1092852926101047"
    }
  ],
  "subjects": [
    {
      "field": "medicine",
      "origin": "openalex:2738|Schizophrenia research and treatment",
      "subfield": "psychiatry"
    }
  ],
  "title": "Trajectories of gray and white matter volume in children at elevated risk for schizophrenia",
  "title_text": "Trajectories of gray and white matter volume in children at elevated risk for schizophrenia",
  "type": "peer-reviewed",
  "updated_at": "2026-11-08T12:22:33Z",
  "url": "https://research.draconitic.com/paper/79ped08e5d2st",
  "venue": "CNS Spectrums",
  "versions": []
}