{
  "abstract": "Background: While certain metabolic indicators serve as effective predictors for type 2 diabetes (T2D), evidence regarding the role of polyunsaturated fatty acids (including n-3 and n-6) remains inconsistent. Objective(s): This study aims to explore the relationship between blood levels of unsaturated and saturated fatty acids and T2D risk. Methods: This is a secondary analysis of the data from the National Health and Nutrition Examination Survey 2011-2012. A total of 1172 participants were included in this study. Results: After adjusting of all the variables, a positive correlation was observed between α-linolenic acid (18:3 n-3), eicosapentaenoic acid (20:5 n-3), and docosahexaenoic acid (22:6 n-3) with T2D risk (OR in quintile3, (18:3 n-3): OR = 8.989, 95% CI: 1.536-52.611; (22:6 n3): OR = 7.626, 95% CI: 1.551-37.500; OR in quintile4: (20:5n-3): OR = 15.855, 95% CI: 3.203-78.482). For n-6 polyunsaturated fatty acids (PUFA) dihomo-gamma-linolenic acid (20:3 n-6) and docosapentaenoic-6 acid (22:5 n6) were associated with decreased T2D risk. The monounsaturated fatty acids (MUFA) cis-vaccenic acid (18:1 n-7) and nervonic acid (24:1 n9) were associated with higher risk of T2D (18:1 n7): OR = 9.784, 95% CI: 1.688-56.705; (24:1n9): OR = 10.295, 95% CI: 1.505-70.411). For saturated fatty acids (SFA), arachidic acid (20:0), behenic acid (22:0), and lignoceric acid (24:0) were found to be associated with a greater risk of developing T2D risk. Conclusion: Circulating fatty acid species showed differential relationship with T2D risk. Given the observational design, this relationship should be interpreted cautiously and confirmed in prospective and mechanistic studies.",
  "abstract_shown": true,
  "affiliations": [
    "Department of Home Economics, Faculty of Specific Education, University of Ain Shams, Cairo, Egypt",
    "DSM Nutritional Products Inc Columbia, USA"
  ],
  "article_type": null,
  "arxiv": null,
  "author_total": 2,
  "authors": [
    {
      "affs": [
        0
      ],
      "name": "Nahed Hussein"
    },
    {
      "affs": [
        1
      ],
      "name": "Norman Salem"
    }
  ],
  "bibtex": "https://research.draconitic.com/paper/79th61pvthp9x.bib",
  "cited_by": 0,
  "doi": "10.21608/jhiph.2026.479577.1221",
  "fulltext_url": null,
  "id": "79th61pvthp9x",
  "issns": [
    "2357-0601",
    "2357-061X"
  ],
  "landing_url": "https://doi.org/10.21608/jhiph.2026.479577.1221",
  "language": "en",
  "licence": "CC-BY-SA",
  "licence_label": "CC BY-SA",
  "licence_source": "journal",
  "licence_url": "https://creativecommons.org/licenses/by-sa/4.0/",
  "metadata_licence": null,
  "native_subjects": [
    [
      "lcc",
      "R"
    ],
    [
      "openalex",
      "2916|Fatty Acid Research and Health"
    ]
  ],
  "openalex": "W7203690439",
  "pdf_url": null,
  "pmcid": null,
  "pmid": null,
  "published": "2026-08-01",
  "publisher": "Alexandria University, High Institute of Public Health",
  "ris": "https://research.draconitic.com/paper/79th61pvthp9x.ris",
  "sources": [
    {
      "first_seen": "2026-10-31T14:23:00Z",
      "native_id": "344b9d1ef05744569d0f108024bbb3f5",
      "source": "doaj",
      "url": "https://doi.org/10.21608/jhiph.2026.479577.1221"
    }
  ],
  "subjects": [
    {
      "field": "medicine",
      "origin": "lcc:R",
      "subfield": "general"
    }
  ],
  "title": "Relationship Between Circulating Serum Fatty Acids and Type 2 Diabetes Risk: An Analysis of the National Health and Nutrition Examination Survey 2011-2012 Study",
  "title_text": "Relationship Between Circulating Serum Fatty Acids and Type 2 Diabetes Risk: An Analysis of the National Health and Nutrition Examination Survey 2011-2012 Study",
  "type": "peer-reviewed",
  "updated_at": "2026-10-31T14:23:00Z",
  "url": "https://research.draconitic.com/paper/79th61pvthp9x",
  "venue": "Journal of High Institute of Public Health",
  "versions": []
}