{
  "abstract": "Adenomyoepithelioma (AME) of the breast is an exceptionally rare biphasic neoplasm. Although predominantly benign, malignant AME (M-AME) presents considerable diagnostic challenges. We report a 75-year-old woman with a painless, progressively enlarging 5×5 cm left breast mass. Mammography demonstrated well-defined opacities with irregular margins and fine calcifications (BI-RADS 5), whereas core needle biopsy favored a benign lesion with epithelial and myoepithelial proliferation arranged in nests and trabeculae. Wide local excision established the diagnosis of biphasic M-AME with myoepithelial carcinoma (pT3, Nottingham Grade 2), characterized by increased mitotic activity, comedo-type necrosis, and perineural invasion. Immunohistochemistry confirmed dual epithelial and myoepithelial differentiation. Notably, the tumor demonstrated estrogen receptor positivity, an uncommon finding in M-AME. The patient subsequently underwent completion mastectomy and remains recurrence free at two-year follow-up. This case underscores the diagnostic limitations of core needle biopsy and the importance of excisional biopsy when radiologic and histopathologic findings are discordant.",
  "abstract_shown": true,
  "affiliations": [
    "B.P. Koirala Institute of Health Sciences, Dharan, Sunsari, Nepal.",
    "Manipal College of Medical Sciences, Pokhara, Kaski, Nepal."
  ],
  "article_type": null,
  "arxiv": null,
  "author_total": 5,
  "authors": [
    {
      "affs": [
        0
      ],
      "name": "Satyam Mandal"
    },
    {
      "affs": [
        1
      ],
      "name": "Sandeep Kshetri"
    },
    {
      "affs": [
        0
      ],
      "name": "Roshan Niraula"
    },
    {
      "affs": [
        0
      ],
      "name": "Sangharsha Ghimire"
    },
    {
      "affs": [
        0
      ],
      "name": "Sagar Pokhrel"
    }
  ],
  "bibtex": "https://research.draconitic.com/paper/79wchhwvpwknb.bib",
  "cited_by": 0,
  "doi": "10.31729/jnma.v64i303.9693",
  "fulltext_url": "https://jnma.com.np/jnma/index.php/jnma/article/view/9693",
  "id": "79wchhwvpwknb",
  "issns": [
    "0028-2715",
    "1815-672X"
  ],
  "landing_url": "https://doi.org/10.31729/jnma.v64i303.9693",
  "language": "en",
  "licence": "CC-BY",
  "licence_label": "CC BY",
  "licence_source": "journal",
  "licence_url": "https://creativecommons.org/licenses/by/4.0/",
  "metadata_licence": null,
  "native_subjects": [
    [
      "lcc",
      "R5-920"
    ]
  ],
  "openalex": null,
  "pdf_url": null,
  "pmcid": null,
  "pmid": null,
  "published": "2026-10-31",
  "publisher": "Nepal Medical Association",
  "ris": "https://research.draconitic.com/paper/79wchhwvpwknb.ris",
  "sources": [
    {
      "first_seen": "2026-10-31T14:23:00Z",
      "native_id": "4b155652e9b440c481f44eb73d4e8d8c",
      "source": "doaj",
      "url": "https://doi.org/10.31729/jnma.v64i303.9693"
    }
  ],
  "subjects": [
    {
      "field": "medicine",
      "origin": "lcc:R5-920",
      "subfield": "general"
    }
  ],
  "title": "Malignant Adenomyoepithelioma of Breast: A Rare and Challenging Diagnostic Entity.",
  "title_text": "Malignant Adenomyoepithelioma of Breast: A Rare and Challenging Diagnostic Entity.",
  "type": "peer-reviewed",
  "updated_at": "2026-10-31T14:23:00Z",
  "url": "https://research.draconitic.com/paper/79wchhwvpwknb",
  "venue": "Journal of Nepal Medical Association",
  "versions": []
}