{
  "abstract": "Background\n\nApproximately 30% of sinonasal and nasopharyngeal carcinoma cases are HPV-associated, yet studies investigating circulating tumor HPV-DNA (ctHPV-DNA) among these patients are scarce. The aim of this study was to investigate the sensitivity of ctHPV-DNA in pretreatment blood samples from patients with HPV-positive (HPV+) sinonasal and nasopharyngeal carcinoma.Methods\n\nPatients with a confirmed HPV+ sinonasal or nasopharyngeal carcinoma treated at the Department of Otorhinolaryngology, Head and Neck Surgery and Audiology at Rigshospitalet, Copenhagen, Denmark in the period 2017-2025 were included in this study. Blood samples were drawn in Streck tubes before treatment initiation and analysed for the presence of ctHPV-DNA by Droplet digital PCR (ddPCR).Results\n\nFifteen patients with primary HPV+ sinonasal or nasopharyngeal carcinoma were included. Except for two cases of HPV-related multiphenotypic carcinoma, all cases were squamous cell carcinoma. HPV16 was most prevalent and found in 6 patients (40%). HPV18 (n = 2), HPV33 (n = 1), HPV35 (n = 3), HPV45 (n = 1), and HPV56 (n = 2) were also represented. The sensitivity of detecting ctHPV-DNA in the pretreatment blood samples of the included patients was 80%. The level of ctHPV-DNA increased significantly with increasing T-category.Conclusion\n\nctHPV-DNA was detected in pretreatment blood samples in 80% of patients with HPV+ sinonasal and nasopharyngeal carcinoma. This supports further investigation of ctHPV-DNA as a biomarker for post-treatment surveillance in these patients.",
  "abstract_shown": true,
  "affiliations": [
    "Department of Otorhinolaryngology, Head and Neck Surgery and Audiology, Copenhagen University Hospital - Rigshospitalet, Denmark.",
    "Department of Pathology, Copenhagen University Hospital - Rigshospitalet, Denmark.",
    "MDxCORE, Department of Clinical Biochemistry, Copenhagen University Hospital - Rigshospitalet, Denmark; Department of Clinical Medicine, Faculty of Health and Medical Sciences, University of Copenhagen."
  ],
  "article_type": null,
  "arxiv": null,
  "author_total": 7,
  "authors": [
    {
      "affs": [
        0
      ],
      "name": "Jakob Myllerup Jensen"
    },
    {
      "affs": [
        0
      ],
      "name": "Simone Kloch Bendtsen"
    },
    {
      "affs": [
        0
      ],
      "name": "Kathrine Kronberg Jakobsen"
    },
    {
      "affs": [
        1
      ],
      "name": "Katalin Kiss"
    },
    {
      "affs": [
        2
      ],
      "name": "Maria Rossing"
    },
    {
      "affs": [
        0
      ],
      "name": "Christian Grønhøj"
    },
    {
      "affs": [
        0
      ],
      "name": "Christian Von Buchwald"
    }
  ],
  "bibtex": "https://research.draconitic.com/paper/7a0rp7ywcjkqf.bib",
  "cited_by": 0,
  "doi": "10.2340/1651-226x.2026.46393",
  "fulltext_url": "https://europepmc.org/articles/PMC13688294",
  "id": "7a0rp7ywcjkqf",
  "issns": [
    "0284-186X",
    "1651-226X"
  ],
  "landing_url": "https://europepmc.org/article/MED/42898009",
  "language": "eng",
  "licence": "CC-BY",
  "licence_label": "CC BY",
  "licence_source": "article",
  "licence_url": "https://creativecommons.org/licenses/by/4.0/",
  "metadata_licence": null,
  "native_subjects": [
    [
      "openalex",
      "2733|Head and Neck Cancer Studies"
    ]
  ],
  "openalex": "W7223015198",
  "pdf_url": "https://europepmc.org/articles/PMC13688294?pdf=render",
  "pmcid": "PMC13688294",
  "pmid": "42898009",
  "published": "2026-10-20",
  "publisher": null,
  "ris": "https://research.draconitic.com/paper/7a0rp7ywcjkqf.ris",
  "sources": [
    {
      "first_seen": "2026-10-30T12:19:32Z",
      "native_id": "MED:42898009",
      "source": "europepmc",
      "url": "https://europepmc.org/article/MED/42898009"
    }
  ],
  "subjects": [
    {
      "field": "medicine",
      "origin": "openalex:2733|Head and Neck Cancer Studies",
      "subfield": "general"
    }
  ],
  "title": "Detection of circulating tumor HPV-DNA in patients with HPV-positive sinonasal and nasopharyngeal carcinoma.",
  "title_text": "Detection of circulating tumor HPV-DNA in patients with HPV-positive sinonasal and nasopharyngeal carcinoma.",
  "type": "peer-reviewed",
  "updated_at": "2026-10-30T12:19:32Z",
  "url": "https://research.draconitic.com/paper/7a0rp7ywcjkqf",
  "venue": "Acta oncologica (Stockholm, Sweden)",
  "versions": []
}