{
  "abstract": "Objective: To evaluate the impact of intensive insulin therapy (IIT) within 1 week on glycemic control and β-cell function indices in patients with type 2 diabetes mellitus (T2DM). Methods: This retrospective study included 726 patients with T2DM who underwent continuous subcutaneous insulin infusion within 1 week. Patients were divided into three groups based on disease duration: short (≤1 year), medium (>1 and <10 years), and long (≥10 years) duration groups. The primary outcome was the changes in glycemic control and β-cell function indices after IIT. Factors influencing the improvement in β-cell function metrics were also analyzed. Results: After IIT within 1 week, fasting plasma glucose (FPG) and postprandial plasma glucose (PPG) levels significantly decreased (p < 0.01 for both). HOMA-β, 30 min insulinogenic index, 30 min disposition index, and insulin secretion sensitivity index-2 markedly improved from baseline [37.69 (41.03) VS. 32.40 (46.06), 3.16 (3.97) VS. 2.12 (3.51), 336.85 (397.05) VS. 188.93 (263.45), and 185.92 (122.89) VS. 120.81 (90.12), respectively] (p < 0.01 for all). Insulin sensitivity, measured by HOMA-IR and Matsuda index, significantly improved (p < 0.01 for both). Significantly greater improvements in glycemic control and β-cell function measures were observed in patients with a shorter diabetes duration. Age, duration of diabetes, BMI, HbA1c, duration of IIT, and time in range were significantly associated with improvements in β-cell function indices. Conclusions: IIT within 1 week was associated with improved glycemic control and β-cell function indices in T2DM patients, with the most pronounced benefits observed in those with a shorter disease duration.",
  "abstract_shown": true,
  "affiliations": [
    "Department of General Medicine, The Third Affiliated Hospital of Sun Yat-Sen University, Guangzhou 510530, China",
    "Department of Endocrinology and Metabolism, The Third Affiliated Hospital of Sun Yat-Sen University, Key Laboratory of Diabetology of Guangdong Province, Guangzhou 510630, China",
    "Department of Endocrinology, The People’s Hospital of Baoan Shenzhen, The Second Affiliated Hospital of Shenzhen University, Shenzhen Hospital of Guangdong Provincial People’s Hospital, The Affiliated Baoan Hospital of Southern Medical University, Shenzhen Baoan Clinical Medical School of Guangdong Medical University, The 8th People’s Hospital of Shenzhen, Shenzhen 518000, China"
  ],
  "article_type": null,
  "arxiv": null,
  "author_total": 11,
  "authors": [
    {
      "affs": [
        0
      ],
      "name": "Wei Jiang",
      "orcid": "0009-0007-4911-7727"
    },
    {
      "affs": [
        1
      ],
      "name": "Xubin Yang"
    },
    {
      "affs": [
        1
      ],
      "name": "Beisi Lin"
    },
    {
      "affs": [
        2
      ],
      "name": "Zhigu Liu"
    },
    {
      "affs": [
        0
      ],
      "name": "Xuanrong Chen"
    },
    {
      "affs": [
        1
      ],
      "name": "Shuo Lin"
    },
    {
      "affs": [
        1
      ],
      "name": "Daizhi Yang"
    },
    {
      "affs": [
        1
      ],
      "name": "Yintong Huang",
      "orcid": "0009-0008-2058-410X"
    },
    {
      "affs": [
        1
      ],
      "name": "Ruofan Wang"
    },
    {
      "affs": [
        1
      ],
      "name": "Wen Xu",
      "orcid": "0000-0002-8258-2707"
    },
    {
      "affs": [
        1
      ],
      "name": "Longyi Zeng",
      "orcid": "0000-0003-4234-6459"
    }
  ],
  "bibtex": "https://research.draconitic.com/paper/7a1v6qnr759x4.bib",
  "cited_by": 0,
  "doi": "10.3390/jcm15218297",
  "fulltext_url": null,
  "id": "7a1v6qnr759x4",
  "issns": [
    "2077-0383"
  ],
  "landing_url": "https://www.mdpi.com/2077-0383/15/21/8297",
  "language": null,
  "licence": "CC-BY-4.0",
  "licence_label": "CC BY 4.0",
  "licence_source": "article",
  "licence_url": "https://creativecommons.org/licenses/by/4.0/",
  "metadata_licence": null,
  "native_subjects": [
    [
      "openalex",
      "2712|Diabetes Treatment and Management"
    ]
  ],
  "openalex": "W7223989338",
  "pdf_url": null,
  "pmcid": null,
  "pmid": null,
  "published": "2026-10-25",
  "publisher": "MDPI AG",
  "ris": "https://research.draconitic.com/paper/7a1v6qnr759x4.ris",
  "sources": [
    {
      "first_seen": "2026-10-30T12:20:01Z",
      "native_id": "10.3390/jcm15218297",
      "source": "crossref",
      "url": "https://www.mdpi.com/2077-0383/15/21/8297"
    }
  ],
  "subjects": [
    {
      "field": "medicine",
      "origin": "openalex:2712|Diabetes Treatment and Management",
      "subfield": "endocrinology-metabolism"
    }
  ],
  "title": "Effects of Intensive Insulin Therapy Within One Week on Glycemic Control and β-Cell Function in Patients with T2DM",
  "title_text": "Effects of Intensive Insulin Therapy Within One Week on Glycemic Control and β-Cell Function in Patients with T2DM",
  "type": "peer-reviewed",
  "updated_at": "2026-10-30T12:20:01Z",
  "url": "https://research.draconitic.com/paper/7a1v6qnr759x4",
  "venue": "Journal of Clinical Medicine",
  "versions": []
}