{
  "abstract": "T-cell-engaging therapies have revolutionized care for relapsed or refractory large B-cell lymphoma. Transformed follicular lymphoma (tFL) has had limited representation in CAR-T or bispecific antibody trials. Thus, outcomes in this subgroup are not well-described. Furthermore, trials that include aggressive disease transformed from indolent lymphomas often report collective outcomes rather than results for individual histologic subsets despite biologic heterogeneity; this limits interpretability of results. Despite these limitations, there are consistent signals that tFL responds well to T-cell-engaging therapies. tFL has a unique tumor microenvironment, but it is not clear if or how this contributes to the favorable outcomes. More robust data are available for CAR-T compared to bispecifics in this population and differences in responsiveness between the two therapies are difficult to ascertain. More research is needed to better understand biologic interaction of tFL with T-cell-engaging therapies and response to therapy to inform future clinical trials.",
  "abstract_shown": true,
  "affiliations": [
    "Feinberg School of Medicine, Northwestern University, Chicago, IL 60611, USA",
    "Robert H. Lurie Comprehensive Cancer Center, Chicago, IL 60611, USA"
  ],
  "article_type": null,
  "arxiv": null,
  "author_total": 2,
  "authors": [
    {
      "affs": [
        0
      ],
      "name": "Viktoriya Zelikson"
    },
    {
      "affs": [
        1
      ],
      "name": "Reem Karmali",
      "orcid": "0000-0003-0984-4376"
    }
  ],
  "bibtex": "https://research.draconitic.com/paper/7a5ax7sna1fka.bib",
  "cited_by": 0,
  "doi": "10.3390/cancers18203391",
  "fulltext_url": null,
  "id": "7a5ax7sna1fka",
  "issns": [
    "2072-6694"
  ],
  "landing_url": "https://www.mdpi.com/2072-6694/18/20/3391",
  "language": null,
  "licence": "CC-BY-4.0",
  "licence_label": "CC BY 4.0",
  "licence_source": "article",
  "licence_url": "https://creativecommons.org/licenses/by/4.0/",
  "metadata_licence": null,
  "native_subjects": [
    [
      "openalex",
      "2734|Lymphoma Diagnosis and Treatment"
    ]
  ],
  "openalex": "W7223055484",
  "pdf_url": null,
  "pmcid": null,
  "pmid": null,
  "published": "2026-10-20",
  "publisher": "MDPI AG",
  "ris": "https://research.draconitic.com/paper/7a5ax7sna1fka.ris",
  "sources": [
    {
      "first_seen": "2026-10-30T12:19:58Z",
      "native_id": "10.3390/cancers18203391",
      "source": "crossref",
      "url": "https://www.mdpi.com/2072-6694/18/20/3391"
    }
  ],
  "subjects": [
    {
      "field": "medicine",
      "origin": "issn:2072-6694",
      "subfield": "oncology"
    }
  ],
  "title": "Navigating T-Cell-Directed Therapies in Transformed Follicular Lymphoma",
  "title_text": "Navigating T-Cell-Directed Therapies in Transformed Follicular Lymphoma",
  "type": "peer-reviewed",
  "updated_at": "2026-10-30T12:19:58Z",
  "url": "https://research.draconitic.com/paper/7a5ax7sna1fka",
  "venue": "Cancers",
  "versions": []
}