{
  "abstract": "IntroductionCognitive intraindividual variability (IIV), a measure of fluctuation in performance across time or tasks, is an emerging marker of cognitive decline. However, little is known about within-domain IIV in Latino adults. To address this gap, we examined memory IIV and hippocampal integrity in older Latino individuals.\n\nMethodsSixty-seven participants from the Boston Latino Aging Study underwent cognitive testing and MRI. Linear regressions assessed whether memory IIV was associated with hippocampal volume and hippocampus-cingulum tract fractional anisotropy. Additional analyses evaluated associations using mean memory performance as the outcome.\n\nResultsHigher mean performance was associated with greater hippocampal volume ({beta}=0.24, p=.03), while memory IIV was not ({beta}=0.028, p=.84). Higher memory IIV was associated with lower fractional anisotropy in the hippocampus-cingulum tract ({beta}=-0.34, p<.01), while mean performance was not ({beta}=-0.07, p=.52).\n\nDiscussionMemory IIV may be more closely linked to hippocampal white matter, while mean memory performance may better reflect hippocampal volume.",
  "abstract_shown": true,
  "affiliations": [
    "Department of Psychological & Brain Sciences, Boston University, Boston, Massachusetts, USA"
  ],
  "article_type": "PUBLISHAHEADOFPRINT",
  "arxiv": null,
  "author_total": 13,
  "authors": [
    {
      "affs": [
        0
      ],
      "name": "A. I. Gonzalez"
    },
    {
      "name": "C. Tristao-Pereira"
    },
    {
      "name": "L. Martinez"
    },
    {
      "name": "N. J. Ramirez"
    },
    {
      "name": "G. Aquilino Silva"
    },
    {
      "name": "J. Alcina"
    },
    {
      "name": "J. E. Martinez"
    },
    {
      "name": "A. Giudicessi"
    },
    {
      "name": "V. Ku"
    },
    {
      "name": "M. C. Rowe"
    },
    {
      "name": "L. A. Ramirez-Gomez"
    },
    {
      "name": "D. G. Saldana"
    },
    {
      "name": "Y. T. Quiroz"
    }
  ],
  "bibtex": "https://research.draconitic.com/paper/7a7pkyffs3ssz.bib",
  "cited_by": 0,
  "doi": "10.64898/2026.10.15.26365658",
  "fulltext_url": "https://www.medrxiv.org/content/10.64898/2026.10.15.26365658v1.full",
  "id": "7a7pkyffs3ssz",
  "issns": [],
  "landing_url": "https://www.medrxiv.org/content/10.64898/2026.10.15.26365658v1",
  "language": null,
  "licence": "CC-BY-NC-ND",
  "licence_label": "CC BY-NC-ND",
  "licence_source": "article",
  "licence_url": "https://creativecommons.org/licenses/by-nc-nd/4.0/",
  "metadata_licence": null,
  "native_subjects": [
    [
      "medrxiv",
      "neurology"
    ],
    [
      "openalex",
      "2738|Dementia and Cognitive Impairment Research"
    ]
  ],
  "openalex": "W7222974957",
  "pdf_url": "https://www.medrxiv.org/content/10.64898/2026.10.15.26365658v1.full.pdf",
  "pmcid": null,
  "pmid": null,
  "published": "2026-10-15",
  "publisher": null,
  "ris": "https://research.draconitic.com/paper/7a7pkyffs3ssz.ris",
  "sources": [
    {
      "first_seen": "2026-10-30T12:21:10Z",
      "native_id": "10.64898/2026.10.15.26365658",
      "source": "medrxiv",
      "url": "https://www.medrxiv.org/content/10.64898/2026.10.15.26365658v1"
    }
  ],
  "subjects": [
    {
      "field": "medicine",
      "origin": "medrxiv:neurology",
      "subfield": "neurology"
    }
  ],
  "title": "Memory Intraindividual Variability and its Association with Hippocampal Integrity in Older Latino Adults Without Dementia",
  "title_text": "Memory Intraindividual Variability and its Association with Hippocampal Integrity in Older Latino Adults Without Dementia",
  "type": "preprint",
  "updated_at": "2026-10-30T12:21:10Z",
  "url": "https://research.draconitic.com/paper/7a7pkyffs3ssz",
  "venue": "medRxiv",
  "versions": []
}