{
  "abstract": "Alzheimer's disease (AD) is a progressive neurodegenerative disorder characterized by cognitive decline, oxidative stress, and amyloid-beta accumulation. Natural products with antioxidant and stress-response-modulating properties are increasingly being investigated as candidate neuroprotective agents. In this study, we evaluated the effects of Rhodiola rosea L. extract, salidroside, and rosavin in Caenorhabditis elegans models of AD. Phenotypic, behavioral, biochemical, and molecular assays were used to assess locomotion, egg laying, chemotaxis, reactive oxygen species (ROS), gene expression, and amyloid-like aggregation. The extract and its related compounds improved locomotor performance, partially rescued reproductive and sensory defects, reduced ROS accumulation, modulated stress-response genes including skn-1/nrf2, daf-2, and sod-1, and decreased thioflavin-S-positive aggregates. Together, these findings support the potential neuroprotective effect of R. rosea extract and its key marker compounds, suggesting the involvement of conserved antioxidant pathways.",
  "abstract_shown": true,
  "affiliations": [
    "Department of Pharmacology, Toxicology and Therapeutic Chemistry, University of Barcelona, Av. Joan XXIII, 27-31, 08035 Barcelona, Spain.",
    "Institute of Neurosciences, University of Barcelona, 08035 Barcelona, Spain.",
    "Centro de Investigación en Red, Enfermedades Neurodegenerativas (CIBERNED), Instituto de Salud Carlos III, 28029 Madrid, Spain.",
    "Neuchâtel Platform of Analytical Chemistry, University of Neuchâtel, Avenue de Bellevaux 51, 2000 Neuchâtel, Switzerland.",
    "Laboratory of Eukaryotic Cell Biology, Department of Biotechnology, The Stephan Angeloff Institute of Microbiology, Bulgarian Academy of Sciences, 139 Ruski Blvd., 4000 Plovdiv, Bulgaria."
  ],
  "article_type": "research article",
  "arxiv": null,
  "author_total": 4,
  "authors": [
    {
      "affs": [
        0,
        1
      ],
      "name": "Aina Bellver-Sanchis",
      "orcid": "0000-0001-9890-753X"
    },
    {
      "affs": [
        0,
        1,
        2
      ],
      "name": "Christian Griñán-Ferré",
      "orcid": "0000-0002-5424-9130"
    },
    {
      "affs": [
        3
      ],
      "name": "Sylvain Sutour",
      "orcid": "0000-0001-9676-7123"
    },
    {
      "affs": [
        4
      ],
      "name": "Andrey S Marchev",
      "orcid": "0000-0002-7660-683X"
    }
  ],
  "bibtex": "https://research.draconitic.com/paper/7atx7pk4asy10.bib",
  "cited_by": 0,
  "doi": "10.3390/ijms27198701",
  "fulltext_url": "https://europepmc.org/articles/PMC13665325",
  "id": "7atx7pk4asy10",
  "issns": [
    "1422-0067"
  ],
  "landing_url": "https://europepmc.org/article/MED/42883945",
  "language": "eng",
  "licence": "CC-BY",
  "licence_label": "CC BY",
  "licence_source": "article",
  "licence_url": "https://creativecommons.org/licenses/by/4.0/",
  "metadata_licence": null,
  "native_subjects": [
    [
      "openalex",
      "1312|Medicinal Plants and Bioactive Compounds"
    ]
  ],
  "openalex": "W7212167453",
  "pdf_url": "https://europepmc.org/articles/PMC13665325?pdf=render",
  "pmcid": "PMC13665325",
  "pmid": "42883945",
  "published": "2026-09-29",
  "publisher": null,
  "ris": "https://research.draconitic.com/paper/7atx7pk4asy10.ris",
  "sources": [
    {
      "first_seen": "2026-10-30T12:19:16Z",
      "native_id": "MED:42883945",
      "source": "europepmc",
      "url": "https://europepmc.org/article/MED/42883945"
    }
  ],
  "subjects": [
    {
      "field": "biochemistry",
      "origin": "openalex:1312|Medicinal Plants and Bioactive Compounds",
      "subfield": "molecular-biology"
    }
  ],
  "title": "Effect of Rhodiola rosea L. Extract on Alzheimer's Disease-like Symptoms in Caenorhabditis elegans.",
  "title_text": "Effect of Rhodiola rosea L. Extract on Alzheimer's Disease-like Symptoms in Caenorhabditis elegans.",
  "type": "peer-reviewed",
  "updated_at": "2026-10-30T12:19:16Z",
  "url": "https://research.draconitic.com/paper/7atx7pk4asy10",
  "venue": "International journal of molecular sciences",
  "versions": []
}