{
  "abstract": "Which experiences persist as memories is a fundamental question in neurobiology. The balance between memory persistence and suppression is thought to be optimal for an organism to adapt to the ever-changing environment. Memory suppression is a process by which the brain limits the strength and expression of memories. Memory suppressors are genes whose disruption can enhance memory at different stages: acquisition, consolidation, forgetting, or recall. Here, using aversive classical conditioning in Drosophila, we show that Gq acts as a memory suppressor in PPL1 dopaminergic neurons. Knockdown of gq in dopaminergic neurons enhances acquisition, strengthens anesthesia-resistant memory, and impairs reversal learning. In vivo functional imaging revealed that gq knockdown amplifies shock-evoked responses in a type of PPL1 neuron. Additionally, using ex vivo imaging and pharmacological experiments, we reveal that both Gq and the OAMB receptor alter octopamine-evoked ER calcium responses in PPL1 neurons. Our results uncover a new role of Gq signaling within dopaminergic neurons that suppresses memory.",
  "abstract_shown": true,
  "affiliations": [
    "Georgetown University"
  ],
  "article_type": "New results",
  "arxiv": null,
  "author_total": 3,
  "authors": [
    {
      "name": "J. C. Martinez-Cervantes"
    },
    {
      "name": "P. Shah"
    },
    {
      "affs": [
        0
      ],
      "name": "I. Cervantes Sandoval"
    }
  ],
  "bibtex": "https://research.draconitic.com/paper/7b7fsx168wz93.bib",
  "cited_by": 0,
  "doi": "10.64898/2026.10.13.758534",
  "fulltext_url": "https://www.biorxiv.org/content/10.64898/2026.10.13.758534v1.full",
  "id": "7b7fsx168wz93",
  "issns": [
    "2692-8205"
  ],
  "landing_url": "https://www.biorxiv.org/content/10.64898/2026.10.13.758534v1",
  "language": "eng",
  "licence": "CC-BY-NC",
  "licence_label": "CC BY-NC",
  "licence_source": "article",
  "licence_url": "https://creativecommons.org/licenses/by-nc/4.0/",
  "metadata_licence": null,
  "native_subjects": [
    [
      "biorxiv",
      "neuroscience"
    ],
    [
      "openalex",
      "2804|Neurobiology and Insect Physiology Research"
    ]
  ],
  "openalex": "W7221766215",
  "pdf_url": "https://www.biorxiv.org/content/10.64898/2026.10.13.758534v1.full.pdf",
  "pmcid": "PMC13742397",
  "pmid": null,
  "published": "2026-10-13",
  "publisher": null,
  "ris": "https://research.draconitic.com/paper/7b7fsx168wz93.ris",
  "sources": [
    {
      "first_seen": "2026-10-30T12:27:42Z",
      "native_id": "10.64898/2026.10.13.758534",
      "source": "biorxiv",
      "url": "https://www.biorxiv.org/content/10.64898/2026.10.13.758534v1"
    },
    {
      "first_seen": "2026-11-09T15:20:34Z",
      "native_id": "PMC:PMC13742397",
      "source": "europepmc",
      "url": "https://europepmc.org/article/PMC/PMC13742397"
    }
  ],
  "subjects": [
    {
      "field": "biology",
      "origin": "biorxiv:neuroscience",
      "subfield": "neuroscience"
    }
  ],
  "title": "A gαq signaling pathway in dopaminergic neurons suppresses memory",
  "title_text": "A gαq signaling pathway in dopaminergic neurons suppresses memory",
  "type": "preprint",
  "updated_at": "2026-11-09T15:20:34Z",
  "url": "https://research.draconitic.com/paper/7b7fsx168wz93",
  "venue": "bioRxiv",
  "versions": []
}