{
  "abstract": "Long non-coding RNAs (lncRNAs) play crucial roles in the onset and progression of cardiovascular disease, particularly atherosclerosis. However, the role of PARD3-AS1 in atherosclerosis remains largely uncharacterized. This study therefore aimed to investigate the impact of the PARD3-AS1/miR-668-3p axis on atherosclerosis. The expression levels of PARD3-AS1 and miR-668-3p in human umbilical vein endothelial cells (HUVECs) were quantified by quantitative real-time polymerase chain reaction (RT-qPCR). HUVEC proliferation was assessed using a Cell Counting Kit-8 (CCK-8) assay and 5-ethynyl-2′-deoxyuridine (EdU) incorporation, and migratory and invasive capacities were evaluated using wound healing and Transwell assays. The interaction between PARD3-AS1 and miR-668-3p was confirmed by bioinformatics analysis and dual-luciferase reporter assays. In addition, serum samples were collected from patients diagnosed with atherosclerosis, and ApoE⁻/⁻ C57BL/6 mice were fed a high-fat diet for 8 weeks to establish a model of atherosclerosis. PARD3-AS1 expression was significantly reduced in the serum of patients with atherosclerosis, whereas miR-668-3p levels were markedly elevated, and the two were negatively correlated. Subsequent experiments confirmed that miR-668-3p effectively reversed the promotion effects of PARD3-AS1 on HUVEC proliferation and migration. In vivo, histological staining showed that the PARD3-AS1 overexpression group exhibited improved endothelial repair. Collectively, these findings demonstrate that PARD3-AS1 directly interacts with miR-668-3p to modulate HUVEC proliferation, migration, and invasion, suggesting that PARD3-AS1 may serve as a potential therapeutic target for atherosclerosis.",
  "abstract_shown": true,
  "affiliations": [
    "Department of Vascular Surgery, The Affiliated Hospital of Qingdao University",
    "Department of Obstetrics and Gynecology, People’s Hospital of Zhaoyuan City"
  ],
  "article_type": null,
  "arxiv": null,
  "author_total": 7,
  "authors": [
    {
      "affs": [
        0
      ],
      "name": "Xiaozhi Sun"
    },
    {
      "affs": [
        1
      ],
      "name": "Linlin Zhang"
    },
    {
      "affs": [
        0
      ],
      "name": "Xinxing Wang"
    },
    {
      "affs": [
        0
      ],
      "name": "Junwei Yan"
    },
    {
      "affs": [
        0
      ],
      "name": "Xuefei Jiao"
    },
    {
      "affs": [
        0
      ],
      "name": "Yongxin Li"
    },
    {
      "affs": [
        0
      ],
      "name": "Mingjin Guo"
    }
  ],
  "bibtex": "https://research.draconitic.com/paper/7bc260mmjf25v.bib",
  "cited_by": 0,
  "doi": "10.1038/s41598-026-62404-7",
  "fulltext_url": "https://doi.org/10.1038/s41598-026-62404-7",
  "id": "7bc260mmjf25v",
  "issns": [
    "2045-2322"
  ],
  "landing_url": "https://doi.org/10.1038/s41598-026-62404-7",
  "language": "en",
  "licence": "CC-BY",
  "licence_label": "CC BY",
  "licence_source": "journal",
  "licence_url": "https://creativecommons.org/licenses/by/4.0/",
  "metadata_licence": null,
  "native_subjects": [
    [
      "lcc",
      "Q"
    ],
    [
      "lcc",
      "R"
    ],
    [
      "openalex",
      "2403|Atherosclerosis and Cardiovascular Diseases"
    ]
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  "openalex": "W7169830860",
  "pdf_url": "https://www.nature.com/articles/s41598-026-62404-7_reference.pdf",
  "pmcid": null,
  "pmid": null,
  "published": "2026-07-01",
  "publisher": "Nature Portfolio",
  "ris": "https://research.draconitic.com/paper/7bc260mmjf25v.ris",
  "sources": [
    {
      "first_seen": "2026-10-30T13:45:46Z",
      "native_id": "85ac13eeb94947eabc3d7b5624905d43",
      "source": "doaj",
      "url": "https://doi.org/10.1038/s41598-026-62404-7"
    }
  ],
  "subjects": [
    {
      "field": "biology",
      "origin": "openalex:2403|Atherosclerosis and Cardiovascular Diseases",
      "subfield": "immunology"
    }
  ],
  "title": "LncRNA PARD3-AS1 regulates the proliferation and migration of human umbilical vein endothelial cells in atherosclerosis by targeting miR-668-3p",
  "title_text": "LncRNA PARD3-AS1 regulates the proliferation and migration of human umbilical vein endothelial cells in atherosclerosis by targeting miR-668-3p",
  "type": "peer-reviewed",
  "updated_at": "2026-10-30T13:45:46Z",
  "url": "https://research.draconitic.com/paper/7bc260mmjf25v",
  "venue": "Scientific Reports",
  "versions": []
}