{
  "abstract": "Genotypes in the 17q12-q21 asthma risk locus and early-life viral wheezing illnessesTo the Editor, Infections with rhinovirus (RV) or respiratory syncytial virus (RSV) are the two most common triggers of wheezing illnesses in preschoolers.These illnesses are leading causes of hospitalization in the early years and also represent a significant risk factor for developing childhood asthma.1,2 While lower respiratory illnesses caused by RSV are preventable, there are no vaccines or antivirals available for RVs.This therapeutic gap highlights the critical need to identify the pathogenic mechanisms behind virus-induced wheezing illnesses and to develop new strategies for treatment or prevention.Genetic, environmental, and personal factors contribute to the risk of preschool wheezing illnesses.These include genes that regulate immune responses and cell-surface receptors utilized by viruses.A genomic region on chromosome 17q12-q21, which encodes the genes ORMDL3 and GSDMB, significantly increases the risk for viral wheeze.3 Interestingly, this region is also the most significant and replicated locus for childhood-onset asthma, 4,5 especially in children with a history of wheeze 6 and/or RV wheeze.3 In a combined editing.Tina V. Hartert: Data curation; writing -review and editing.",
  "abstract_shown": true,
  "affiliations": [],
  "article_type": null,
  "arxiv": null,
  "author_total": 22,
  "authors": [
    {
      "name": "N. Schoettler"
    },
    {
      "name": "T. Gebretsadik"
    },
    {
      "name": "S. Singh"
    },
    {
      "name": "L. Gress"
    },
    {
      "name": "E. A. Mendonça"
    },
    {
      "name": "B. M. Snyder"
    },
    {
      "name": "A. A. Eapen"
    },
    {
      "name": "P. Lebeau"
    },
    {
      "name": "R. Gangnon"
    },
    {
      "name": "C. M. Seroogy"
    },
    {
      "name": "L. B. Bacharier"
    },
    {
      "name": "Jr. Lemanske"
    },
    {
      "name": "S. V. Lynch"
    },
    {
      "name": "D. R. Gold"
    },
    {
      "name": "R. L. Miller"
    },
    {
      "name": "D. J. Jackson"
    },
    {
      "name": "G. K. K. Hershey"
    },
    {
      "name": "C. C. Johnson"
    },
    {
      "name": "F. D. Martinez"
    },
    {
      "name": "C. Ober"
    },
    {
      "name": "T. V. Hartert"
    },
    {
      "name": "J. E. Gern"
    }
  ],
  "bibtex": "https://research.draconitic.com/paper/7bengqk1cna80.bib",
  "cited_by": 2,
  "doi": "10.1111/pai.70165",
  "fulltext_url": null,
  "id": "7bengqk1cna80",
  "issns": [
    "0905-6157",
    "1399-3038"
  ],
  "landing_url": "https://hal.science/hal-05787896v1",
  "language": "en",
  "licence": "CC-BY",
  "licence_label": "CC BY",
  "licence_source": "journal",
  "licence_url": "https://creativecommons.org/licenses/by/4.0/",
  "metadata_licence": null,
  "native_subjects": [
    [
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    [
      "openalex",
      "2737|Asthma and respiratory diseases"
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  "pdf_url": "https://onlinelibrary.wiley.com/doi/pdfdirect/10.1111/pai.70165",
  "pmcid": null,
  "pmid": null,
  "published": "2026-10-09",
  "publisher": "Wiley",
  "ris": "https://research.draconitic.com/paper/7bengqk1cna80.ris",
  "sources": [
    {
      "first_seen": "2026-10-30T12:17:51Z",
      "native_id": "hal-05787896",
      "source": "hal",
      "url": "https://hal.science/hal-05787896v1"
    }
  ],
  "subjects": [
    {
      "field": "biology",
      "origin": "hal:1.sdv.mp",
      "subfield": "microbiology"
    }
  ],
  "title": "Genotypes in the 17q12-q21 asthma risk locus and early-life viral wheezing illnesses",
  "title_text": "Genotypes in the 17q12-q21 asthma risk locus and early-life viral wheezing illnesses",
  "type": "peer-reviewed",
  "updated_at": "2026-10-30T12:17:51Z",
  "url": "https://research.draconitic.com/paper/7bengqk1cna80",
  "venue": "Pediatric Allergy and Immunology",
  "versions": []
}