{
  "abstract": "Chiral Cu-catalyzed asymmetric remote ε-arylation/cyclization of yne-indole esters with 5-aminopyrazoles is reported to construct polycyclic fused seven-membered azaheterocycles. After systematic screening of copper sources, chiral ligands, bases and temperature protocols, the optimized CuCl2/L12/DABCO system delivers products in good yields and high enantioselectivities. This transformation exhibits broad substrate compatibility, and steric/electronic effects on stereocontrol are discussed.",
  "abstract_shown": true,
  "affiliations": [
    "School of Chemistry and Chemical Engineering/State Key Laboratory Incubation Base for Green Processing of Chemical Engineering",
    "Shihezi University"
  ],
  "article_type": null,
  "arxiv": null,
  "author_total": 4,
  "authors": [
    {
      "affs": [
        0,
        1
      ],
      "name": "Jiaqi Pu"
    },
    {
      "affs": [
        0,
        1
      ],
      "name": "Huanshi Wang"
    },
    {
      "affs": [
        0,
        1
      ],
      "name": "Yongsheng Li"
    },
    {
      "affs": [
        0,
        1
      ],
      "name": "Shi-Wu Li",
      "orcid": "0000-0003-0699-0140"
    }
  ],
  "bibtex": "https://research.draconitic.com/paper/7bewpbshcxpnw.bib",
  "cited_by": 0,
  "doi": "10.26434/chemrxiv.15010872/v1",
  "fulltext_url": null,
  "id": "7bewpbshcxpnw",
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  "landing_url": "https://chemrxiv.org/doi/full/10.26434/chemrxiv.15010872/v1",
  "language": null,
  "licence": "CC-BY",
  "licence_label": "CC BY",
  "licence_source": "journal",
  "licence_url": "https://creativecommons.org/licenses/by/4.0/",
  "metadata_licence": null,
  "native_subjects": [
    [
      "openalex",
      "1605|Catalytic Alkyne Reactions"
    ]
  ],
  "openalex": "W7223188591",
  "pdf_url": "https://chemrxiv.org/doi/pdf/10.26434/chemrxiv.15010872/v1",
  "pmcid": null,
  "pmid": null,
  "published": "2026-10-22",
  "publisher": "American Chemical Society (ACS)",
  "ris": "https://research.draconitic.com/paper/7bewpbshcxpnw.ris",
  "sources": [
    {
      "first_seen": "2026-10-30T12:17:26Z",
      "native_id": "10.26434/chemrxiv.15010872",
      "source": "chemrxiv",
      "url": "https://chemrxiv.org/doi/full/10.26434/chemrxiv.15010872/v1"
    }
  ],
  "subjects": [
    {
      "field": "chemistry",
      "origin": "openalex:1605|Catalytic Alkyne Reactions",
      "subfield": "organic"
    }
  ],
  "title": "Copper-Catalyzed Asymmetric Remote ε-Arylation/Cyclization of Yne-Indole Esters with 5-Aminopyrazoles toward Polycyclic Fused Seven-Membered Azaheterocycles",
  "title_text": "Copper-Catalyzed Asymmetric Remote ε-Arylation/Cyclization of Yne-Indole Esters with 5-Aminopyrazoles toward Polycyclic Fused Seven-Membered Azaheterocycles",
  "type": "preprint",
  "updated_at": "2026-10-30T12:17:26Z",
  "url": "https://research.draconitic.com/paper/7bewpbshcxpnw",
  "venue": "ChemRxiv",
  "versions": []
}