{
  "abstract": "The Wnt/β-catenin pathway plays a critical role in colorectal cancer (CRC) development. The significance of Wnt/β-catenin in maintaining the stability of adult tissues and challenges in identifying suitable molecular targets have limited the application of targeting the Wnt/β-catenin pathway. As one of the Cullin RING Ligase 4 adapters, DNA damage-binding protein 1 (DDB1) - and CUL4 correlation factor 13 (DCAF13) appears strongly expressed in different tumors. Our findings confirm enhanced expression of DCAF13 in tissues of CRC origin and related cell. In colon cancer cells, DCAF13 regulated adenomatous polyposis coli membrane recruitment 2 (AMER2) through ubiquitination, DCAF13 deletion increased AMER2 expression, which inhibited Wnt/β-catenin activity, suppressing cell proliferation. This effect was further validated in mice with gut-specific DCAF13 knockout. The ubiquitin-proteasome system is a potential target for drug development and cancer treatment. Beta-propeller proteins, such as CRL4 adapter DCAFs, are easily targeted by drugs. DCAF-proteolysis-targeting chimeras (PROTACs) can overcome drug resistance and selectively target tumor drivers by leveraging the unique substrate specificity of the DCAF subunits. DCAF13 emerges as a promising target for CRC, acting via the DCAF13-AMER2-Wnt /β-catenin axis.",
  "abstract_shown": true,
  "affiliations": [
    "Department of Histoembryology and Cell Biology, College of Medicine, Jiaxing University, Jiaxing, China",
    "Zhejiang Chinese Medicine University and Jiaxing University Master Degree Cultivation Base, Jiaxing University, Jiaxing, China",
    "Department of Geriatrics, Ulanqab City Center Hospital, Ulanqab City, China",
    "College of Pharmacy, Zhejiang University of Technology, Hangzhou, China",
    "Department of Pathology, First Affiliated Hospital of Jiaxing University/The First Hospital of Jiaxing, Jiaxing, China",
    "Department of Gastrointestinal Surgery, First Affiliated of Jiaxing University/ The First Hospital of Jiaxing, Jiaxing, China",
    "Department of Anesthesiology, Baoji People’s Hospital, Baoji, China",
    "Institute of Information Network and Artificial Intelligence, Jiaxing University, Jiaxing, China",
    "Institute of Basic Medicine and Cancer (IBMC), Chinese Academy of Sciences, Hangzhou, China",
    "Department of Gastrointestinal Surgery, Tongcheng People’s Hospital, Tongcheng, China",
    "Gynecology department, First Affiliated Hospital of Jiaxing University/The First Hospital of Jiaxing, Jiaxing, China",
    "G60 STI Valley Industry & Innovation Institute, Jiaxing University, Jiaxing, China",
    "Engineering Research Center of Intelligent Human Health Situation Awareness of Zhejiang Province, Jiaxing University, Jiaxing, China",
    "Department of Hepatic Surgery VI, Eastern Hepatobiliary Surgery Hospital, Second Military Medical University, Shanghai, China"
  ],
  "article_type": "research article",
  "arxiv": null,
  "author_total": 15,
  "authors": [
    {
      "affs": [
        0,
        1
      ],
      "name": "Yu-Xin Hua"
    },
    {
      "affs": [
        0,
        2
      ],
      "name": "Jie Gao"
    },
    {
      "affs": [
        0,
        3
      ],
      "name": "Qing-Qing Sun"
    },
    {
      "affs": [
        0
      ],
      "name": "Xiao-Min Wang"
    },
    {
      "affs": [
        4
      ],
      "name": "Jing-Yu Wang"
    },
    {
      "affs": [
        5
      ],
      "name": "Yuan Zhou"
    },
    {
      "affs": [
        6
      ],
      "name": "Long Zhang"
    },
    {
      "affs": [
        7
      ],
      "name": "Xian-Chao Zhang"
    },
    {
      "affs": [
        8
      ],
      "name": "Chun-Wei Xu"
    },
    {
      "affs": [
        9
      ],
      "name": "Bing Bao"
    },
    {
      "affs": [
        10
      ],
      "name": "Su-Ping Tao"
    },
    {
      "affs": [
        0
      ],
      "name": "Ying Xu"
    },
    {
      "affs": [
        0,
        11,
        12
      ],
      "name": "Wei-Wei Pan"
    },
    {
      "affs": [
        13
      ],
      "name": "Shu-Qun Cheng"
    },
    {
      "affs": [
        0
      ],
      "name": "Sheng-Bing Liu"
    }
  ],
  "bibtex": "https://research.draconitic.com/paper/7bkqs1w8a3d97.bib",
  "cited_by": 0,
  "doi": "10.1038/s41698-026-01603-x",
  "fulltext_url": "https://pmc.ncbi.nlm.nih.gov/articles/PMC13736966/",
  "id": "7bkqs1w8a3d97",
  "issns": [
    "2397-768X"
  ],
  "landing_url": "https://doi.org/10.1038/s41698-026-01603-x",
  "language": "en",
  "licence": "CC-BY-NC-ND-4.0",
  "licence_label": "CC BY-NC-ND 4.0",
  "licence_source": "article",
  "licence_url": "https://creativecommons.org/licenses/by-nc-nd/4.0/",
  "metadata_licence": null,
  "native_subjects": [
    [
      "heading",
      "Article"
    ],
    [
      "openalex",
      "1312|Wnt/β-catenin signaling in development and cancer"
    ]
  ],
  "openalex": "W7168143602",
  "pdf_url": null,
  "pmcid": "PMC13736966",
  "pmid": "42443527",
  "published": "2026-07-13",
  "publisher": "Nature Publishing Group",
  "ris": "https://research.draconitic.com/paper/7bkqs1w8a3d97.ris",
  "sources": [
    {
      "first_seen": "2026-11-09T12:22:17Z",
      "native_id": "PMC13736966",
      "source": "pmc",
      "url": "https://doi.org/10.1038/s41698-026-01603-x"
    }
  ],
  "subjects": [
    {
      "field": "biochemistry",
      "origin": "openalex:1312|Wnt/β-catenin signaling in development and cancer",
      "subfield": "molecular-biology"
    }
  ],
  "title": "DCAF13: a positive regulator of colon cancer cell proliferation via the AMER2/ Wnt/β-catenin pathway",
  "title_text": "DCAF13: a positive regulator of colon cancer cell proliferation via the AMER2/ Wnt/β-catenin pathway",
  "type": "peer-reviewed",
  "updated_at": "2026-11-09T12:22:17Z",
  "url": "https://research.draconitic.com/paper/7bkqs1w8a3d97",
  "venue": "NPJ Precision Oncology",
  "versions": []
}