{
  "abstract": "Proton boron capture therapy (PBCT), based on proton-boron fusion reactions (¹¹B + p →3α + 8.7 MeV), has the potential to enhance the biological effectiveness of proton therapy. To achieve this potential, the efficient delivery of enough ¹¹B to cancer cells will be paramount. This study demonstrates a newly developed method of poor solvent-mediated spontaneous assembly of polymeric micelles with entrapped o-carborane, in which ethanol is a good solvent for the payload o-carborane but a poor solvent for the hydrophobic segment poly(ε-caprolactone) in this amphiphilic block copolymer. This method provided smaller polymeric micelles compared to use of tetrahydrofuran, a good solvent for the amphiphilic block copolymer, as the sole solvent for both payload and copolymer. The prepared nanoscale formulation enabled the boron-rich cage compound o-carborane to be effectively delivered to tumor cells, and its enhancement of the biological effectiveness of proton therapy was preliminarily validated in a pancreatic ductal adenocarcinoma cell line, MiaPaCa-2, by survival assays and DNA damage assessment. The ¹¹¹In-labeled congener was also successfully prepared and used in biodistribution assays in normal mice, opening the way to further studies on image-guided PBCT in preclinical animal models.",
  "abstract_shown": true,
  "affiliations": [
    "Departments of Cancer Systems Imaging - Unit 1907, The University of Texas MD Anderson Cancer Center, 1881 East Road, Houston, TX 77054, USA.",
    "Department of Nuclear Sciences and Engineering, Center of Nuclear Sciences and Technologies, Instituto Superior Técnico, University of Lisboa, Estrada Nacional 10, Km 139.7, Bobadela LRS 2695-066, Portugal.",
    "Radiation Physics, The University of Texas MD Anderson Cancer Center, Houston, TX 77054, USA."
  ],
  "article_type": "research article",
  "arxiv": null,
  "author_total": 10,
  "authors": [
    {
      "affs": [
        0
      ],
      "name": "Guodong Zhang"
    },
    {
      "affs": [
        0
      ],
      "name": "Qiu-Xu Teng"
    },
    {
      "affs": [
        1
      ],
      "name": "Célia Fernandes"
    },
    {
      "affs": [
        0
      ],
      "name": "Haiyan Chen"
    },
    {
      "affs": [
        1
      ],
      "name": "Filipa Mendes"
    },
    {
      "affs": [
        2
      ],
      "name": "Narayan Sahoo"
    },
    {
      "affs": [
        0
      ],
      "name": "Ping Pan"
    },
    {
      "affs": [
        1
      ],
      "name": "Lurdes Gano"
    },
    {
      "affs": [
        1
      ],
      "name": "António Paulo"
    },
    {
      "affs": [
        0
      ],
      "name": "Chun Li"
    }
  ],
  "bibtex": "https://research.draconitic.com/paper/7c5zmjgsayg43.bib",
  "cited_by": 0,
  "doi": "10.1186/s12645-026-00400-2",
  "fulltext_url": "https://europepmc.org/articles/PMC13679845",
  "id": "7c5zmjgsayg43",
  "issns": [
    "1868-6958",
    "1868-6966"
  ],
  "landing_url": "https://europepmc.org/article/MED/42898988",
  "language": "eng",
  "licence": "CC-BY",
  "licence_label": "CC BY",
  "licence_source": "article",
  "licence_url": "https://creativecommons.org/licenses/by/4.0/",
  "metadata_licence": null,
  "native_subjects": [
    [
      "openalex",
      "2741|Boron Compounds in Chemistry"
    ]
  ],
  "openalex": "W7166311790",
  "pdf_url": "https://europepmc.org/articles/PMC13679845?pdf=render",
  "pmcid": "PMC13679845",
  "pmid": "42898988",
  "published": "2026-06-28",
  "publisher": null,
  "ris": "https://research.draconitic.com/paper/7c5zmjgsayg43.ris",
  "sources": [
    {
      "first_seen": "2026-10-30T12:19:42Z",
      "native_id": "MED:42898988",
      "source": "europepmc",
      "url": "https://europepmc.org/article/MED/42898988"
    }
  ],
  "subjects": [
    {
      "field": "medicine",
      "origin": "openalex:2741|Boron Compounds in Chemistry",
      "subfield": "imaging"
    }
  ],
  "title": "o-carborane encapsulated into polymeric micelles for proton boron capture therapy.",
  "title_text": "o-carborane encapsulated into polymeric micelles for proton boron capture therapy.",
  "type": "peer-reviewed",
  "updated_at": "2026-10-30T12:19:42Z",
  "url": "https://research.draconitic.com/paper/7c5zmjgsayg43",
  "venue": "Cancer nanotechnology",
  "versions": []
}