{
  "abstract": "Background\n\n[⁶⁸Ga]Ga-DOTATATE PET/CT has been widely used in the diagnosis and staging of gastroenteropancreatic neuroendocrine tumors (GEP-NETs), while PET/MR may have greater advantages in the diagnosis of hepatic lesions. This study aimed to compare the diagnostic performance of conventional [⁶⁸Ga]Ga-DOTATATE PET/CT and delayed PET/MR in detecting hepatic metastases in patients with GEP-NETs.Methods\n\nThis prospective observational study enrolled GEP-NETs patients with liver metastases who underwent conventional [⁶⁸Ga]Ga-DOTATATE PET/CT followed by delayed PET/MR of the upper abdomen on the same day. The final status of all identified lesions was defined by a composite reference standard integrating histopathology, clinical follow-up, and contrast-enhanced MRI findings. Lesion detection rates, maximum standardized uptake value (SUVmax), target-to-background ratio (TBR), sensitivity, specificity, and accuracy were compared between the two modalities.Results\n\n46 patients (mean age 56.4 ± 12.9 years, 18 males and 28 females) were included. A total of 542 liver metastases were identified, with PET/CT detecting 368 (67.9%) lesions and delayed PET/MR contributing an additional 146 (94.8%) lesions. For matched lesions, SUVmax and TBR values showed no statistically significant differences between PET/CT and delayed PET/MR imaging (17.2 ± 11.0 vs. 16.4 ± 10.8, P = 0.746; 4.1 ± 3.6 vs. 4.0 ± 2.8, P = 0.178, respectively). For additional lesions detected on delayed PET/MR, 54 high-uptake liver metastases were identified (mean diameter 4.7 ± 1.9 mm; SUVmax 9.1 ± 2.2), along with 92 non-uptake lesions (mean diameter 5.5 ± 2.3 mm; Z = - 2.149, P = 0.0315). The sensitivity, specificity and accuracy between conventional PET/CT and delayed PET/MR were (65.9% vs. 92.4%, P < 0.001), (59.3% vs. 51.9%, P = 0.77) and (65.6% vs.90.5%, P < 0.001), respectively.Conclusion\n\nDelayed [⁶⁸Ga]Ga-DOTATATE PET/MR with an optimized acquisition protocol improved liver metastasis detection in GEP-NETs compared with conventional PET/CT. Combining PET/CT with delayed PET/MR provides a complementary strategy for hepatic staging in selected clinical settings.",
  "abstract_shown": true,
  "affiliations": [
    "Department of Nuclear Medicine, The First Affiliated Hospital, Fujian Medical University, Fuzhou, 350005, China.",
    "Department of Nuclear Medicine, National Regional Medical Center, Binhai Campus of the First Affiliated Hospital, Fujian Medical University, Fuzhou, 350212, China.",
    "Department of Nuclear Medicine, Provincial Clinical Key Specialty of Fujian, Fuzhou, 350212, China.",
    ", No. 20 Chazhong Road, Taijiang District, Fuzhou, China.",
    "Department of Nuclear Medicine, The First Affiliated Hospital, Fujian Medical University, Fuzhou, 350005, China. miaoweibing@126.com.",
    "Department of Nuclear Medicine, National Regional Medical Center, Binhai Campus of the First Affiliated Hospital, Fujian Medical University, Fuzhou, 350212, China. miaoweibing@126.com.",
    "Department of Nuclear Medicine, Provincial Clinical Key Specialty of Fujian, Fuzhou, 350212, China. miaoweibing@126.com.",
    "Fujian Key Laboratory of Precision Medicine for Cancer, The First Affiliated Hospital, Fujian Medical University, Fuzhou, 350005, China. miaoweibing@126.com.",
    ", No. 20 Chazhong Road, Taijiang District, Fuzhou, China. miaoweibing@126.com."
  ],
  "article_type": "research article",
  "arxiv": null,
  "author_total": 6,
  "authors": [
    {
      "affs": [
        0,
        1,
        2,
        3
      ],
      "name": "Zefang Lin"
    },
    {
      "affs": [
        0,
        1,
        2,
        3
      ],
      "name": "Sen Ma"
    },
    {
      "affs": [
        0,
        1,
        2
      ],
      "name": "Shaoming Chen"
    },
    {
      "affs": [
        0,
        1,
        2
      ],
      "name": "Jiaying Zhang"
    },
    {
      "affs": [
        0,
        1,
        2
      ],
      "name": "Zenan Wu"
    },
    {
      "affs": [
        4,
        5,
        6,
        7,
        8
      ],
      "name": "Weibing Miao"
    }
  ],
  "bibtex": "https://research.draconitic.com/paper/7cde799gck4t3.bib",
  "cited_by": 0,
  "doi": "10.1186/s12880-026-02641-4",
  "fulltext_url": "https://europepmc.org/articles/PMC13729658",
  "id": "7cde799gck4t3",
  "issns": [
    "1471-2342"
  ],
  "landing_url": "https://europepmc.org/article/MED/42972535",
  "language": "eng",
  "licence": "CC-BY-NC-ND",
  "licence_label": "CC BY-NC-ND",
  "licence_source": "article",
  "licence_url": "https://creativecommons.org/licenses/by-nc-nd/4.0/",
  "metadata_licence": null,
  "native_subjects": [
    [
      "heading",
      "Research"
    ],
    [
      "openalex",
      "2713|Neuroendocrine Tumor Research Advances"
    ]
  ],
  "openalex": "W7172005816",
  "pdf_url": "https://europepmc.org/articles/PMC13729658?pdf=render",
  "pmcid": "PMC13729658",
  "pmid": "42972535",
  "published": "2026-07-31",
  "publisher": "BMC",
  "ris": "https://research.draconitic.com/paper/7cde799gck4t3.ris",
  "sources": [
    {
      "first_seen": "2026-11-04T15:20:45Z",
      "native_id": "MED:42972535",
      "source": "europepmc",
      "url": "https://europepmc.org/article/MED/42972535"
    },
    {
      "first_seen": "2026-11-07T12:22:22Z",
      "native_id": "PMC13729658",
      "source": "pmc",
      "url": "https://doi.org/10.1186/s12880-026-02641-4"
    }
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  "subjects": [
    {
      "field": "medicine",
      "origin": "openalex:2713|Neuroendocrine Tumor Research Advances",
      "subfield": "epidemiology-public-health"
    }
  ],
  "title": "Incremental value of delayed [⁶⁸Ga]Ga-DOTATATE PET/MR in the detection of liver metastases from gastroenteropancreatic neuroendocrine tumors.",
  "title_text": "Incremental value of delayed [⁶⁸Ga]Ga-DOTATATE PET/MR in the detection of liver metastases from gastroenteropancreatic neuroendocrine tumors.",
  "type": "peer-reviewed",
  "updated_at": "2026-11-07T12:22:22Z",
  "url": "https://research.draconitic.com/paper/7cde799gck4t3",
  "venue": "BMC medical imaging",
  "versions": []
}