{
  "abstract": "Background & aims: Liver transplantation (LT) is indicated for liver complications related to hepatitis B virus (HBV) infection: acute liver failure (ALF), decompensated cirrhosis or hepatocellular carcinoma (HCC). The present study aimed to describe and evaluate patient survival after LT for HBV-related disease in France and identify the factors influencing survival. Methods: The present retrospective cohort study based on medical record information included all adult patients transplanted with positive HBsAg (+/- coinfection with Hepatitis D virus (HDV)) between January 1, 2005 and December 31, 2023 in all French LT centres. Results: The study population consisted of 1083 patients, the majority of whom were men (81.5%) with a median [IQR] age at LT listing of 52.8 [42.5-59.8] years. Indications for LT were HBV-related HCC (47.2%), HBV-related cirrhosis (28.5%), HDV-related cirrhosis (11.2%), HBV-related ALF (10.5%), HDV-related HCC (1.4%) and other (0.7%). Median [IQR] post-LT follow-up was 6.0 [2.2-11.1] years. Patient survival at 1, 5, 10 and 15 years after LT was 91.6%, 80.1%, 71.8% and 63.6% respectively. Multivariate analysis showed that independent significant prognostic factors were age at LT (HR: 1.030; 95CI: 1.019-1.042; p < 0.0001) and the pre-LT nucleos(t)ides analogue (NUC) regimen: in comparison to tenofovir, the use of entecavir alone (HR: 1.735; 95CI: 1.312-2.295; p < 0.0001) or another NUC or combination therapy (HR: 1.471; 95CI: 1.059-2.043; p = 0.021) were associated with decreased survival. Conclusions: Survival after LT for HBV-related liver disease is good. NUC type prior to LT seems to be associated with patient survival.",
  "abstract_shown": true,
  "affiliations": [],
  "article_type": null,
  "arxiv": null,
  "author_total": 29,
  "authors": [
    {
      "name": "Isaure Bienvenue"
    },
    {
      "name": "Olivier Roux"
    },
    {
      "name": "Audrey Coilly"
    },
    {
      "name": "Armand Abergel"
    },
    {
      "name": "Teresa Antonini"
    },
    {
      "name": "Thierry Artzner"
    },
    {
      "name": "Olivier Boillot"
    },
    {
      "name": "Faïza Chermak"
    },
    {
      "name": "Filomena Conti"
    },
    {
      "name": "Sébastien Dharancy"
    },
    {
      "name": "Christophe Duvoux"
    },
    {
      "name": "Laure Elkrief"
    },
    {
      "name": "Marwin Farrugia"
    },
    {
      "name": "Claire Francoz"
    },
    {
      "name": "Baptiste Giguet"
    },
    {
      "name": "Jean Hardwigsen"
    },
    {
      "name": "Pauline Houssel‐debry"
    },
    {
      "name": "Marie-Noelle Hilleret"
    },
    {
      "name": "Nassim Kamar"
    },
    {
      "name": "Marianne Latournerie"
    },
    {
      "name": "Magdalena Meszaros"
    },
    {
      "name": "Sylvie Radenne"
    },
    {
      "name": "Bruno Roche"
    },
    {
      "name": "Ephrem Salamé"
    },
    {
      "name": "Delphine Verhoeven Weil"
    },
    {
      "name": "Didier Samuel"
    },
    {
      "name": "Fabien Zoulim"
    },
    {
      "name": "Jérôme Dumortier"
    },
    {
      "name": "François Villeret"
    }
  ],
  "bibtex": "https://research.draconitic.com/paper/7cdegd711435c.bib",
  "cited_by": 0,
  "doi": "10.1111/liv.70737",
  "fulltext_url": null,
  "id": "7cdegd711435c",
  "issns": [
    "0106-9543",
    "1600-0676"
  ],
  "landing_url": "https://hal.science/hal-05851707v1",
  "language": "en",
  "licence": "CC-BY-4.0",
  "licence_label": "CC BY 4.0",
  "licence_source": "article",
  "licence_url": "https://creativecommons.org/licenses/by/4.0/",
  "metadata_licence": null,
  "native_subjects": [
    [
      "hal",
      "0.sdv"
    ],
    [
      "openalex",
      "2713|Hepatitis B Virus Studies"
    ]
  ],
  "openalex": "W7164397225",
  "pdf_url": "https://hal.science/hal-05851707/document",
  "pmcid": null,
  "pmid": "42274284",
  "published": "2026-11-04",
  "publisher": null,
  "ris": "https://research.draconitic.com/paper/7cdegd711435c.ris",
  "sources": [
    {
      "first_seen": "2026-11-04T12:20:53Z",
      "native_id": "hal-05851707",
      "source": "hal",
      "url": "https://hal.science/hal-05851707v1"
    }
  ],
  "subjects": [
    {
      "field": "medicine",
      "origin": "openalex:2713|Hepatitis B Virus Studies",
      "subfield": "epidemiology-public-health"
    }
  ],
  "title": "Liver Transplantation for HBV ‐Related Disease in France: NUC Type Before LT Is Associated With Patient Survival",
  "title_text": "Liver Transplantation for HBV ‐Related Disease in France: NUC Type Before LT Is Associated With Patient Survival",
  "type": "peer-reviewed",
  "updated_at": "2026-11-04T12:20:53Z",
  "url": "https://research.draconitic.com/paper/7cdegd711435c",
  "venue": "Liver -Copenhagen-",
  "versions": []
}