{
  "abstract": "Homologous recombination (HR) is a high-fidelity DNA repair pathway responsible for the resolution of double- strand breaks, with the RAD51 recombinase playing a pivotal role through the formation of nucleoprotein fil- aments on single-stranded DNA. Overexpression of RAD51 is frequently observed in cancer cells, where it pro- motes genome stability under genotoxic stress and contributes to acquired resistance to DNA-damaging chemotherapeutic agents. In this study, we report the identification of a novel stilbene-derived compound, the disodium salt of 4,4′-diphenylcarbamate stilbene-2,2′-disulfonic acid (DPDS), as a novel compound that modu- lates RAD51 monomer–monomer interactions and reduces its binding to single-stranded DNA and ATP, processes that are critical for filament assembly and homologous recombination. Furthermore, DPDS enhances the cyto- toxic effect of cisplatin in DU145 prostate cancer cells and was associated with reduced RAD51 nuclear foci formation and increased accumulation of DNA double-strand breaks. Notably, DPDS did not significantly affect cell viability in the four cellular models evaluated under our experimental conditions and displayed lower intrinsic cytotoxicity than DIDS (4,4′-diisothiocyanostilbene-2,2′-disulfonic acid) and emzadirib. Collectively, these findings support that DPDS as a chemical modulator of RAD51 activity may enhance cisplatin sensitivity in DU145 prostate cancer cells.",
  "abstract_shown": true,
  "affiliations": [],
  "article_type": null,
  "arxiv": null,
  "author_total": 8,
  "authors": [
    {
      "name": "Lucie Fonteneau"
    },
    {
      "name": "Houda Benhelli-Mokrani"
    },
    {
      "name": "Céline Robiou Du Pont"
    },
    {
      "name": "Damien Marquis"
    },
    {
      "name": "Jacques Lebreton"
    },
    {
      "name": "Monique Mathé-Allainmat"
    },
    {
      "name": "Benoît Chénais"
    },
    {
      "name": "Fabrice Fleury"
    }
  ],
  "bibtex": "https://research.draconitic.com/paper/7crr3yr49jmt6.bib",
  "cited_by": 0,
  "doi": "10.1016/j.bcp.2026.118393",
  "fulltext_url": null,
  "id": "7crr3yr49jmt6",
  "issns": [
    "0006-2952",
    "1873-2968"
  ],
  "landing_url": "https://hal.science/hal-05761193v1",
  "language": "en",
  "licence": "CC-BY-NC-ND-4.0",
  "licence_label": "CC BY-NC-ND 4.0",
  "licence_source": "article",
  "licence_url": "https://creativecommons.org/licenses/by-nc-nd/4.0/",
  "metadata_licence": null,
  "native_subjects": [
    [
      "hal",
      "0.sdv"
    ],
    [
      "openalex",
      "1312|DNA Repair Mechanisms"
    ]
  ],
  "openalex": "W7204135159",
  "pdf_url": "https://hal.science/hal-05761193/document",
  "pmcid": null,
  "pmid": null,
  "published": "2026-08-24",
  "publisher": "Elsevier",
  "ris": "https://research.draconitic.com/paper/7crr3yr49jmt6.ris",
  "sources": [
    {
      "first_seen": "2026-10-30T12:17:39Z",
      "native_id": "hal-05761193",
      "source": "hal",
      "url": "https://hal.science/hal-05761193v1"
    }
  ],
  "subjects": [
    {
      "field": "biochemistry",
      "origin": "openalex:1312|DNA Repair Mechanisms",
      "subfield": "molecular-biology"
    }
  ],
  "title": "A novel stilbene derivative targets RAD51 activity and sensitizes DU145 prostate cancer cells to cisplatin",
  "title_text": "A novel stilbene derivative targets RAD51 activity and sensitizes DU145 prostate cancer cells to cisplatin",
  "type": "peer-reviewed",
  "updated_at": "2026-10-30T12:17:39Z",
  "url": "https://research.draconitic.com/paper/7crr3yr49jmt6",
  "venue": "Biochemical Pharmacology",
  "versions": []
}